Thermo Fisher Scientific
Thermo Fisher Scientific is a globally renowned leader in scientific solutions, with its microfluidics capabilities being a critical enabler across its diverse portfolio. The company significantly contributes to the microfluidics market by offering specialized array plate technology for digital PCR, which is utilized to achieve greater volume precision and a higher number of microchambers, resulting in highly accurate quantification for researchers. Furthermore, their innovative microfluidics applications extend to mass spectrometry through the ZipChip system, which uses microfluidic separation technology to drastically reduce analysis time and increase sample throughput. The company’s expansive product line and commitment to integrating microfluidic technology into high-throughput systems allow researchers to accelerate drug discovery, diagnostics development, and fundamental biological research. By providing this essential infrastructure, Thermo Fisher cements its position as a key global provider of scientific and technological solutions.
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Sartorius AG
Sartorius AG is a global leader in biopharmaceutical technologies and a top-tier player in the single-use bioreactor (SUB) market, providing advanced solutions from research to commercial production. Their key offerings include the *BIOSTAT STR®* single-use bioreactors, which offer flexible scalability, and the high-throughput *Ambr* micro-bioreactor systems, essential for cell line screening and process development. A core component of their single-use systems is the proprietary *Flexsafe®* film, which is engineered to ensure superior and reproducible cell growth for sensitive cell lines at all scales (up to 2,000L). By focusing on digitalized bioprocess platforms and single-use technology, Sartorius helps biopharma companies reduce investment costs, eliminate the need for cleaning validation, and accelerate the development and manufacturing of biologics and vaccines.
Cytiva (Danaher Corporation)
Cytiva, a subsidiary of the global science and technology conglomerate Danaher Corporation, is a key provider of technologies and services for biomanufacturing. Formed from the life sciences division of GE Healthcare and strengthened by Danaher’s acquisition of Pall Corporation, Cytiva is a leader in single-use and integrated bioprocess solutions. Their prominent offerings include the *Xcellerex™* single-use bioreactors, which are widely used for cell culture processes from research to full-scale production. The portfolio also includes the *iCELLis* single-use bioreactor from Pall, which is specifically designed for high-density adherent cell culture. Cytiva is actively driving innovation by integrating AI-powered bioprocess monitoring and control systems, reinforcing its role in providing the essential technological backbone for next-generation precision medicine and automated, flexible biomanufacturing workflows globally.
Merck KGaA
Merck KGaA is a globally recognized science and technology company that has significantly advanced the single-use bioprocessing market through its Life Science business (MilliporeSigma in North America). The company is a key supplier of single-use bioreactors and consumables for the biotechnology and pharmaceutical industries. Its flagship *Mobius®* single-use bioreactors are essential for minimizing contamination risks and reducing the turnaround time in biopharma manufacturing. Notably, Merck developed the *Mobius ADC Reactor*, a single-use system specifically engineered for the complex and high-value manufacturing of antibody-drug conjugates (ADCs). The company’s focus is on providing high-quality, fully integrated upstream and downstream solutions, backed by continuous global facility expansions to support the rapidly growing demand for single-use bioprocessing products.
Eppendorf SE
Eppendorf SE is a renowned German provider of high-quality laboratory equipment and bioprocess solutions, particularly known for its offerings at the lab and pilot scales. The company is a key market leader in single-use bioreactors, offering the *BioBLU* single-use bioreactor series. These reactors cater to both cell culture and microbial fermentation, with a scalable range of working volumes from 65 mL up to 40 L. Integrating with the *BioFlo®* and *CelliGen®* benchtop systems, Eppendorf’s solutions provide researchers with easy-to-use, low-contamination-risk environments for process development. Their single-use systems feature advanced sensor technology and specialized materials to support challenging applications like stem cell and adherent cell culture, making them vital tools for the R&D stages of biopharmaceutical production.
ABEC Inc.
ABEC Inc. is a leading bioprocess equipment and service company that has pioneered solutions for large-scale biomanufacturing. The company has revolutionized the single-use bioreactor (SUB) market by introducing the largest commercially available systems to date. ABEC was the first to successfully launch 4000-L and 6000-L single-use bioreactors, shattering the industry’s previous 2000 L volume norm. This innovation is critical for the cost-effective scale-up and commercial production of antibody and other biotherapies. By providing these massive-scale disposable systems, ABEC allows clients to achieve full commercial batch sizes while still benefiting from the flexibility, reduced capital expenditure, and lower contamination risk inherent to single-use technology, driving the shift toward high-capacity, flexible manufacturing.
PBS Biotech, Inc.
PBS Biotech is an innovative company specializing in the development and commercialization of next-generation single-use bioreactor systems designed to simplify and accelerate bioprocessing. The company is known for its proprietary, disposable *Vertical-Wheel™ Bioreactor* technology. This unique design provides superior mixing efficiency and gentle agitation, resulting in lower shear stress and better mass transfer compared to traditional stirred-tank or rocking systems. This makes the PBS Biotech system particularly well-suited for culturing sensitive cell lines, such as those used in advanced cell and gene therapies and high-density continuous bioprocessing. By focusing on a distinct fluid dynamics approach within a single-use platform, PBS Biotech offers a high-performance solution that enhances productivity and reliability in modern biomanufacturing workflows.
Distek Inc.
Distek Inc. is a provider of innovative laboratory instruments for the pharmaceutical and bioprocessing industries. The company has a focused presence in the single-use bioreactor market with its *BIOne* product line. The *BIOne Single-Use Bioreactor* and *BIOne Single-Use Fermentor* offer contamination-free and easy-to-scale solutions for both microbial and mammalian cell culture applications. Distek’s emphasis is on user-friendliness and quality assurance, with their single-use components manufactured in an ISO-7 cleanroom and supplied gamma-sterilized. This approach significantly reduces the time and expense associated with the cleaning and sterilization processes required by traditional stainless-steel systems, thereby streamlining R&D and pilot-scale workflows and supporting efficient bioprocessing operations.
Lonza Group
Lonza Group is a leading global Contract Development and Manufacturing Organization (CDMO) that provides extensive services and products to the biopharma industry. While primarily a service provider, Lonza is a crucial player in the single-use bioprocessing market both as a major end-user and as a driver of technology adoption. Its immense experience in manufacturing a wide range of biologics, from vaccines to cell and gene therapies, ensures that its single-use system requirements and collaborations help shape the design and optimization of single-use bioreactors. Lonza’s commitment to quality and regulatory compliance drives the industry standard for single-use technology performance, reinforcing its central role in scaling up and ensuring the reliable commercial production of next-generation therapeutics.
Applikon Biotechnology (Getinge)
Applikon Biotechnology, now a part of the global medical technology group Getinge AB, is a developer and supplier of high-quality bioreactor systems for research and production. The company’s offerings span both traditional stainless steel and advanced single-use bioreactors, particularly targeting the lab and pilot scales. Applikon’s single-use solutions provide researchers with flexible and automated parallel systems that are essential for rapid process development and optimization. The core benefit of their single-use technology is the reduced turnaround time and operational complexity, which is critical for accelerating the early stages of biopharmaceutical development. As part of Getinge, Applikon continues to strengthen its ability to deliver a comprehensive and high-performance portfolio of single-use systems to the global biotechnology market.
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