Sartorius AG
Sartorius AG is a global partner to the biopharmaceutical industry, headquartered in Göttingen, Germany, and tracing its roots back to 1870. The company is consistently ranked as a market leader in Single-Use Bioprocessing (SUB), focusing on advanced bioprocess solutions and laboratory products. Sartorius provides essential infrastructure to facilitate the efficient development and production of biologics. Its flagship offerings in SUB include the BIOSTAT STR® family of stirred-tank bioreactors and the Ambr® micro-bioreactor systems, which are highly valued for their scalability and integration capabilities across process development through commercial manufacturing. Sartorius ensures robust performance through proprietary materials like the Flexsafe film used in their bags, which guarantees optimal cell culture conditions. By offering integrated single-use sensor options and maintaining a focus on digitalized bioprocess platforms, Sartorius addresses the industry’s need for predictable scale-up and reduced contamination risk, solidifying its position among the top four major players globally.
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Thermo Fisher Scientific, Inc.
Thermo Fisher Scientific, Inc. is a world leader in serving science, with its bioprocessing division playing a critical role in the Single-Use Bioprocessing (SUB) market. The company offers an extensive and customizable portfolio of single-use technologies, including bioreactors, fluid management systems, and purification solutions. A key innovation is the HyPerforma™ DynaDrive single-use bioreactor (SUB), which provides a scalable platform for commercial biologics production, capable of reaching volumes up to 5,000L. Thermo Fisher is committed to providing end-to-end bioprocess solutions, from research-scale products to comprehensive production systems like the Enhanced Single-Use Fermentor (S.U.F.). Their strategy involves continuous investment in manufacturing capacity and sustainability, exemplified by the introduction of plant-based films for their single-use bioprocessing containers (BPCs), aimed at reducing their carbon footprint. This broad product line and global supply capability make Thermo Fisher a central provider of the essential tools required for modern biopharmaceutical manufacturing.
Danaher Corporation (Cytiva & Pall)
Danaher Corporation is a diversified global science and technology conglomerate that dominates the Single-Use Bioprocessing (SUB) market through its major subsidiaries, Cytiva and Pall Corporation. Cytiva, formerly GE Healthcare Life Sciences, is renowned for its Xcellerex™ single-use bioreactors, including the X-platform, which simplifies upstream bioprocessing for monoclonal antibodies and cell/gene therapies. Pall contributes vital components such as the Allegro STR single-use bioreactors and Allegro™ biocontainers, known for their superior fluid management and low extractable/leachable profiles. Danaher’s combined portfolio offers integrated and automated single-use systems spanning filtration, mixing, and purification, enabling reliable and scalable workflows. The corporation actively pursues strategic expansions, such as opening innovation hubs globally, to support local biopharmaceutical companies. By integrating these robust technologies, Danaher remains a crucial provider of the technological backbone necessary for next-generation precision medicine and accelerated biomanufacturing.
Merck KGaA (MilliporeSigma)
Merck KGaA, a global science and technology company founded in 1668, is a leading player in the Single-Use Bioprocessing (SUB) market, operating its life science business primarily as MilliporeSigma. The company offers a comprehensive range of high-quality single-use products and services designed to enhance scalability, flexibility, and efficiency in biomanufacturing. Merck’s prominent SUB offerings include the Mobius® single-use bioreactors, which provide scalable solutions for cell culture and protein production, and the specialized Mobius ADC Reactor for antibody-drug conjugate manufacturing. Furthermore, Merck supplies critical consumables such as the Ultimus single-use process container film, filtration systems (TFF and sterile/virus filtration), and single-use assemblies. Through substantial investments in R&D and expansion of its global manufacturing facilities, Merck is focused on maintaining a strong geographic reach and supporting the growing adoption of SUB products in both developed and developing regions, ensuring quality and GMP documentation.
Eppendorf SE
Eppendorf SE, headquartered in Hamburg, Germany, is a global life science company established in 1945, recognized for its precision laboratory equipment and consumables. In the Single-Use Bioprocessing (SUB) sector, Eppendorf plays a crucial role by specializing in smaller-scale, highly flexible single-use systems essential for research and process development. The company’s flagship SUB products are the BioBLU single-use vessels, which range from small to pilot scale (65 mL to 40 L) and are designed for both microbial and cell culture applications. These vessels are integrated into systems like the BioFlo® and CelliGen® benchtop bioreactors, which feature advanced sensor technology. Eppendorf’s focus is on providing user-friendly, closed systems that minimize contamination risk and dramatically reduce the time spent on cleaning and sterilization, thereby accelerating critical process development steps and supporting the efficient scale-up of biopharmaceutical products.
Avantor Inc.
Avantor Inc. is a major global provider of mission-critical products and services to the life sciences and advanced technology sectors. The company’s involvement in the Single-Use Bioprocessing (SUB) market centers on providing essential components and highly customized solutions that support complex biomanufacturing workflows. Avantor supplies a wide array of high-purity materials, fluid handling components, and specialized consumables crucial for preparing media, buffers, and ensuring aseptic transfer. While often serving as an integrator and supplier of key raw materials and components rather than focusing solely on large-scale bioreactors, Avantor’s role is vital in ensuring supply chain continuity and product consistency across single-use platforms. By focusing on quality control and providing customizable single-use assemblies, Avantor helps biopharma manufacturers optimize their processes, reduce turn-around times, and adhere to strict regulatory requirements in the evolving SUB landscape.
Repligen Corporation
Repligen Corporation is a specialized life science company intensely focused on providing high-value bioprocessing technologies used in the manufacture of biologics. Although they offer a comprehensive range of tools, their contribution to the Single-Use Bioprocessing (SUB) market is concentrated on developing highly innovative, disposable solutions for downstream processing and fluid management. Repligen offers single-use filtration and chromatography systems, including pre-packed columns, that enhance productivity and efficiency in purifying therapeutic proteins. The company’s strategy involves leveraging technology and strategic acquisitions to deliver systems that seamlessly integrate into the single-use workflow, facilitating faster, safer, and more scalable drug production. By providing these specialized, consumable products, Repligen addresses critical bottlenecks in the biomanufacturing pipeline, particularly in gene and cell therapy applications, reinforcing its position as a key vendor in the SUB ecosystem.
Lonza Group
Lonza Group, a Swiss multinational manufacturing company, is a leading Contract Development and Manufacturing Organization (CDMO) that is heavily invested in Single-Use Bioprocessing (SUB) technologies. While Lonza’s primary business is providing manufacturing services for pharmaceutical and biotech clients, its extensive operational footprint makes it a critical driver in the adoption and expansion of SUB. Lonza utilizes single-use bioreactors, fluid management systems, and ancillary equipment across its global facilities to offer flexible and scalable production capacity, especially for complex and next-generation therapeutics like cell and gene therapies. Lonza’s involvement includes not only integrating commercially available SUB products but also influencing their design and performance through large-scale deployment and partnerships. By continually investing in single-use capacity and workflow optimization, Lonza demonstrates the practical, commercial application of SUB, thereby accelerating its acceptance throughout the biopharmaceutical industry.
Entegris Inc.
Entegris, Inc. is a global leader in advanced materials science, specializing in systems critical for purifying, safeguarding, and transporting materials in high-tech industries, including biopharmaceuticals. In the Single-Use Bioprocessing (SUB) sector, Entegris focuses on contamination control and fluid management integrity. The company supplies specialized products such as IRIS Single-Use Assemblies, tubing, connectors, and transfer systems, which are integral for connecting various single-use components in an aseptic manner. Entegris’s offerings are designed to be GMP-compatible, providing excellent chemical compatibility and ensuring extremely low levels of extractables and leachables, which is paramount for maintaining product safety and quality. By delivering robust solutions for liquid storage, sampling, and transfer, Entegris ensures seamless integration between different single-use systems, supporting reliable bioprocess continuity at both clinical and commercial scales.
Distek Inc.
Distek, Inc., established in 1976 and headquartered in New Jersey, is a recognized contributor to the Single-Use Bioprocessing (SUB) market, focusing on providing specialized single-use bioreactors and fermentors. The company’s key products include the BIOne Single-Use Bioreactor and BIOne Single-Use Fermentor, designed to provide contamination-free solutions for both microbial fermentation and mammalian cell culture applications. Distek addresses the need for efficient bioprocessing by offering systems that are assembled in ISO-7 cleanrooms and gamma-sterilized, thereby eliminating the resource-intensive steps of cleaning and sterilization associated with traditional stainless-steel equipment. Their systems are characterized by ease-of-scale, supporting a streamlined transition from research stages to larger production volumes. By focusing on specialized, hassle-free single-use vessel technology, Distek supports biopharmaceutical companies seeking to accelerate development timelines and increase operational efficiency.
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