The NGS (Next-Generation Sequencing) sample preparation market is witnessing significant expansion, driven by rapid advancements in sequencing platforms, declining sequencing costs, and the growing demand for precise genomic insights. According to industry reports, the market size is projected to reach USD 4.0 billion by 2028, up from USD 1.9 billion in 2022, growing at a CAGR of 13.4% during the forecast period.
This growth trajectory highlights the importance of NGS as a core technology in modern genomics, diagnostics, and drug discovery. For organizations seeking to innovate in precision medicine and genomic research, understanding the evolving landscape of NGS sample preparation is critical.
Market Drivers: What’s Fueling Growth?
Several prominent factors are contributing to the rising adoption of NGS sample preparation technologies:
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Advancements in NGS Platforms
Continuous innovation in sequencing technologies has improved accuracy, speed, and scalability, making NGS more accessible for a wide range of applications. -
Declining Sequencing Costs
The cost of sequencing has dropped dramatically over the last decade, enabling broader adoption across research institutions, clinical diagnostics, and pharmaceutical companies. -
NGS as a Substitute for PCR
With its high-throughput capabilities, NGS is increasingly being used as a substitute for PCR in various workflows, offering greater efficiency and reliability. -
Improved Genotyping and Preparation Protocols
Enhanced protocols and automation tools have simplified sample preparation, reducing errors and improving consistency in sequencing outcomes.
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Market Segmentation: Key Insights
By Sample Type: DNA Leads the Market
The DNA segment accounted for the largest share of the NGS sample preparation market in 2022. This dominance is driven by:
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The rising prevalence of cancer cases worldwide.
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Increased R&D investments for studying DNA samples in genomics and oncology research.
By Workflow: DNA Fragmentation & Library Preparation Dominates
Within workflows, DNA fragmentation & library preparation emerged as the fastest-growing segment in 2022. Growth in this category is supported by:
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The availability of innovative products.
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Continuous improvements in NGS protocols that enhance accuracy and reduce preparation time.
Other workflows, such as target enrichment and quality control, also play critical roles in ensuring sequencing reliability but are growing at a comparatively slower pace.
By Region: Asia Pacific Leads Growth
The Asia Pacific region is expected to register the highest CAGR through 2028. Several factors contribute to this trend:
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Increasing focus on R&D activities in genomics and biotechnology.
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Growing adoption of NGS in clinical diagnostics and healthcare applications.
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Technological developments in bioinformatics and NGS data analysis.
North America and Europe continue to hold significant shares of the global market, supported by well-established research ecosystems and strong investment pipelines.
Competitive Landscape: Key Players Shaping the Market
The NGS sample preparation market is highly consolidated, with major players leveraging mergers, acquisitions, and product innovations to strengthen their position. Some of the leading companies include:
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Illumina, Inc. (US)
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Thermo Fisher Scientific Inc. (US)
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PerkinElmer Inc. (US)
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F. Hoffmann-La Roche Ltd. (Switzerland)
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Agilent Technologies, Inc. (US)
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QIAGEN (Germany)
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Bio-Rad Laboratories, Inc. (US)
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10x Genomics (US)
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Oxford Nanopore Technologies PLC (UK)
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PacBio (US)
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BGI (China)
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Novogene Co., Ltd. (China)
These companies are actively investing in automation, microfluidics, and integrated workflows to improve throughput and reduce preparation bottlenecks. Collaborations with academic institutions and healthcare organizations are also expanding the practical applications of NGS in clinical and translational research.
Strategic Opportunities for Stakeholders
Organizations involved in life sciences, diagnostics, and pharmaceutical research can capitalize on the growing NGS sample preparation market in several ways:
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Invest in Automation & Workflow Integration
Automation is reshaping sample preparation by reducing manual intervention and improving reproducibility. Companies that integrate advanced technologies such as robotics and AI into preparation workflows are well-positioned for growth. -
Focus on Oncology and Personalized Medicine
With cancer cases on the rise globally, NGS offers significant opportunities in oncology diagnostics and personalized medicine. DNA sequencing in particular is expected to remain a primary driver of adoption. -
Expand Presence in Asia Pacific
The Asia Pacific region offers lucrative growth opportunities due to increasing healthcare investments and expanding genomics research initiatives. Establishing partnerships and local collaborations can unlock new markets. -
Enhance Bioinformatics Capabilities
As sequencing generates massive datasets, robust bioinformatics solutions will be crucial for interpretation. Companies offering end-to-end sequencing and analysis pipelines can deliver greater value to customers.
Future Outlook
The future of the NGS sample preparation market lies in scalability, accuracy, and clinical adoption. As sequencing technologies continue to evolve, the demand for faster, more reliable, and cost-effective preparation methods will only increase.
By 2028, the market is expected to double in size, creating opportunities across research, diagnostics, and drug development. Stakeholders that prioritize innovation, partnerships, and geographic expansion will be best placed to capture long-term growth.
Key Takeaway
The NGS sample preparation market is at the forefront of genomics innovation, fueled by declining sequencing costs, technological advancements, and rising demand for DNA-based research and diagnostics. With a projected CAGR of 13.4%, this market presents vast opportunities for companies aiming to lead in precision medicine and next-generation healthcare solutions.