The single-use bioreactors market is growing rapidly as biopharmaceutical manufacturers increasingly adopt flexible and scalable manufacturing technologies. The growing production of biologics and biosimilars, increasing outsourcing to contract development and manufacturing organizations (CDMOs), and rising demand for advanced therapies are supporting market growth.
The global single-use bioreactors market is projected to reach USD 9.58 billion by 2031, up from an estimated USD 5.43 billion in 2026, registering a CAGR of 12.0% during the forecast period.
Single-use bioreactors are increasingly used for the production of monoclonal antibodies, vaccines, recombinant proteins, viral vectors, and cell & gene therapies. Their flexibility, reduced cleaning requirements, and suitability for modular manufacturing make them attractive to both established pharmaceutical companies and emerging biotechnology companies.
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What Are Single-Use Bioreactors?
Single-use bioreactors are disposable bioprocessing systems used for growing cells and producing biological products.
Unlike traditional stainless-steel bioreactors, single-use systems use disposable bags, assemblies, sensors, and other components that can reduce the need for cleaning and sterilization between batches.
These systems can offer several benefits, including:
- Faster manufacturing setup
- Reduced cleaning and sterilization requirements
- Lower risk of cross-contamination
- Greater manufacturing flexibility
- Easier facility expansion
- Suitability for multiproduct manufacturing
- Support for modular and closed manufacturing workflows
These advantages are increasing the adoption of single-use bioreactor systems across biopharmaceutical manufacturing facilities.
Single-Use Bioreactors Market Growth Drivers
Increasing Biologics Production
The growing demand for biologics is one of the major factors driving the single-use bioreactors market.
Biologics such as monoclonal antibodies, recombinant proteins, vaccines, and advanced therapies require sophisticated cell culture and bioprocessing technologies.
As pharmaceutical and biotechnology companies expand biologics production, demand for scalable single-use bioreactor systems is also increasing.
Growing Adoption of CDMO Services
Pharmaceutical and biotechnology companies are increasingly outsourcing manufacturing activities to CDMOs.
CDMOs need flexible manufacturing systems that can support multiple products and production scales. Single-use technologies can help these organizations quickly configure manufacturing capacity for different projects.
This makes single-use bioreactors particularly attractive for companies managing multiple development and commercial manufacturing programs.
Rising Demand for Cell & Gene Therapies
Cell and gene therapies are creating new opportunities for advanced bioprocessing technologies.
Many of these therapies require flexible manufacturing processes and controlled cell-culture environments. Single-use bioreactors can support applications involving viral vectors and other biological materials used in advanced therapy manufacturing.
Shift Toward Flexible Manufacturing
Biopharmaceutical manufacturers are increasingly moving toward flexible, modular, and closed manufacturing facilities.
Single-use technologies fit well with this approach because disposable bags, fluid-transfer assemblies, sensors, and other components can be integrated into flexible manufacturing workflows.
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Key Applications of Single-Use Bioreactors
Single-use bioreactors are used across a wide range of biopharmaceutical applications.
Monoclonal Antibodies
Monoclonal antibody manufacturing represents an important application for single-use bioreactor technology. Manufacturers use scalable stirred-tank systems to support cell culture and production processes.
Vaccines
The growing demand for vaccines is also supporting the adoption of single-use bioreactor systems. These systems can provide flexible production capacity for different vaccine manufacturing requirements.
Recombinant Proteins
Single-use bioreactors are widely used for recombinant protein production because they can support controlled cell growth and scalable manufacturing processes.
Viral Vectors
The expansion of gene therapy development is increasing demand for viral-vector manufacturing technologies. Single-use systems can support flexible production environments for these applications.
Cell & Gene Therapies
The growing cell and gene therapy pipeline is expected to create additional opportunities for single-use bioreactors, particularly systems designed for smaller-scale, flexible, and intensified manufacturing processes.
Important Trends in the Single-Use Bioreactors Market
Several trends are shaping the future of the market.
Process Intensification
Manufacturers are increasingly looking for ways to produce more biological products using smaller manufacturing footprints.
Process intensification can help improve productivity and reduce facility requirements, supporting demand for advanced single-use bioreactor technologies.
Increased Use of Automation
Automation is becoming increasingly important in biopharmaceutical manufacturing.
Modern bioreactor platforms increasingly incorporate automated control systems, sensors, data collection, and process monitoring to improve consistency and reduce manual intervention.
Closed Manufacturing Workflows
Closed processing is gaining importance because it can reduce contamination risks and improve process control.
Single-use bags, tubing assemblies, connectors, sensors, and other components can be integrated into closed manufacturing workflows.
Expansion of Manufacturing Capacity
Biopharmaceutical companies and CDMOs are investing in additional manufacturing capacity to meet growing demand for biologics and advanced therapies.
This expansion is creating opportunities for suppliers of bioreactors, single-use bags, fluid-management systems, sensors, and related technologies.
Leading Companies in the Single-Use Bioreactors Market
The global single-use bioreactors market is relatively consolidated, with several major companies holding strong positions.
Sartorius AG
Sartorius AG is one of the leading companies in the single-use bioreactors market. Its portfolio includes Ambr high-throughput systems, Biostat RM rocking-motion bioreactors, Biostat STR stirred-tank bioreactors, Flexsafe bags, automation solutions, and fluid-management technologies.
The company has focused on manufacturing capacity expansion, process intensification, automation, and supply-chain resilience.
In June 2025, Sartorius completed an expansion of its Aubagne facility in France, increasing cleanroom space and adding automated production lines for single-use bags.
Danaher Corporation
Danaher Corporation, through Cytiva and Pall Corporation, is another major player in the market.
Cytiva offers Xcellerex X-platform and XDR stirred-tank bioreactors, WAVE rocking bioreactors, sensors, automation systems, and single-use components. Pall adds Allegro bioreactors, filtration technologies, and fluid-management solutions.
Danaher’s broad bioprocessing portfolio allows the company to provide solutions across upstream and downstream manufacturing processes.
Thermo Fisher Scientific
Thermo Fisher Scientific Inc. offers DynaDrive and HyPerforma single-use bioreactors, BioProcess containers, films, fluid-transfer assemblies, controllers, sensors, and filtration technologies.
Its scalable bioreactor platforms support applications ranging from process development to commercial manufacturing.
The company is also investing in bioprocessing capabilities, technical support, and process-development infrastructure to address the growing needs of biopharmaceutical manufacturers.
Merck KGaA
Merck KGaA provides single-use bioreactors and integrated bioprocessing technologies through its Life Science business.
Its portfolio includes Mobius stirred-tank bioreactors, Mobius iFlex systems, Mobius Breez microbioreactors, cell-retention technologies, Flexware assemblies, process containers, and filtration products.
The company’s broad Process Solutions portfolio supports applications such as monoclonal antibodies, recombinant proteins, vaccines, and viral-vector manufacturing.
Competitive Landscape
The single-use bioreactors market is relatively consolidated. Sartorius AG, Danaher Corporation, Thermo Fisher Scientific, and Merck KGaA collectively account for an estimated 70–75% of the global market in 2025, based on the market information provided.
Other important companies include:
- Getinge AB
- Eppendorf SE
- ABEC, Inc.
- PBS Biotech, Inc.
- Distek, Inc.
- Tofflon Life Science Co., Ltd.
- Other specialized bioreactor technology providers
Competition is increasingly focused on scalability, automation, process performance, bag integrity, perfusion compatibility, supply reliability, technical support, and total operating cost.
Companies are also investing in new product launches, acquisitions, partnerships, manufacturing capacity, and geographic expansion to strengthen their market positions.
Future Outlook
The future outlook for the single-use bioreactors market remains strong.
Growing biologics production, increasing use of CDMOs, expanding cell and gene therapy pipelines, and the shift toward flexible manufacturing are expected to continue creating demand for single-use bioprocessing technologies.
The transition toward modular facilities, intensified processes, and closed manufacturing workflows is also expected to encourage greater adoption of single-use bioreactor systems.
As manufacturers look for more flexible and efficient ways to increase production capacity, opportunities are likely to expand for suppliers of single-use bioreactors, disposable bags, sensors, assemblies, fluid-management systems, and process automation technologies.
With the market expected to reach USD 9.58 billion by 2031, companies operating in biopharmaceutical manufacturing and bioprocessing can benefit from closely monitoring emerging technologies, applications, and regional opportunities.
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