Mabtech
Mabtech AB is a world-renowned Swedish company that has been a gold standard in the field of immunological assays since 1986, pioneering and specializing in the development and manufacture of high-sensitivity ELISpot and FluoroSpot solutions. The company offers a comprehensive portfolio that includes more than 350 reliable, ready-to-go, and flexible ELISpot kits, reagents, and advanced instruments, covering over 20 species. Mabtech’s ELISpot kits are trusted by clinical trial labs, pharmaceutical companies, and Contract Research Organizations (CROs) globally for their robustness and superior sensitivity in detecting and quantifying antigen-specific T cell and B cell immune responses at the single-cell level. Their technology is widely utilized across critical applications such as vaccine efficacy assessment, immune modulation monitoring, and cell therapy potency evaluation. A key offering is their next-generation ELISpot reader, the Mabtech ASTOR 2, which leverages innovative RAWSpot™ technology for unmatched analytical precision and user-friendly software to streamline data analysis, further solidifying the company’s position at the forefront of immune monitoring and research infrastructure.
\Cellular Technology Limited (CTL), operating under the brand ImmunoSpot®, is a world leader in the field of cytokine ELISpot assay development, validation, and automated image analysis. Spun off from Case Western Reserve University, CTL’s founding scientists established the technical and scientific foundations of the cytokine ELISPOT assay. The company’s core mission is to elevate ELISpot to an exact science, providing scientifically validated solutions that are critical for regulated clinical trials and basic immunological research. CTL offers the ImmunoSpot® line of analyzers, software, test kits, and extensive Contract Research Services (CRO) for preclinical and clinical trials, specializing in T cell ELISpot. They focus on standardization and high-throughput capabilities, and are known for their ImmunoSpot® analyzer platform which provides objective, transparent, and documented morphometric analysis. CTL was selected as the only ELISpot reference laboratory by the Cancer Vaccine Consortium (CVC), underscoring their global leadership and commitment to advancing all aspects of cellular immune monitoring.
\Bio-Techne Corporation is a diversified global life sciences company that maintains a significant presence in the ELISpot market through its various brands, most notably R\&D Systems and Novus Biologicals. Through R\&D Systems, a trusted name in the immunoassay space, Bio-Techne offers a wide selection of high-quality ELISpot kits and specialized development modules. These products are widely used by researchers and clinicians to accurately enumerate cytokine-secreting cells, making them essential tools for immunological studies, vaccine research, and disease diagnosis. Their portfolio includes single-analyte ELISpot kits designed to quantify one specific target, offering flexibility for do-it-yourself investigators, and comprehensive kits for detecting multiple analytes like IFN-γ and IL-10. Bio-Techne’s commitment to providing robust and reliable reagents and kits ensures high-quality results, supporting scientists in moving efficiently from screening to validation and solidifying its role as a key supplier for the global ELISpot and immunoassay market.
\BioAgilytix is a leading global Contract Research Organization (CRO) with deep specialized expertise in large molecule bioanalysis, and a strong offering in the Enzyme-Linked Immunosorbent Spot (ELISpot) assay. Operating across multiple global locations, BioAgilytix provides robust and reliable ELISpot assays to support preclinical and clinical trials, particularly for monitoring cell-mediated immune responses to novel biologics, cell therapies, and gene therapies. The company is recognized for its ability to qualify and validate ELISpot assays for regulated work, ensuring compliance with strict regulatory standards like 21 CFR Part 11. They utilize high-resolution ImmunoSpot® ELISpot plate readers equipped with top-end optics to deliver high-quality data. BioAgilytix’s services are critical for pharmaceutical and biotech clients who need to accurately assess T cell responses, determine antigenic epitopes, or monitor antigen-specific B cells, making them an essential partner in the advancement of personalized medicine and therapeutic development.
\U-CyTech is a specialized Dutch biotechnology company focused on the development and production of high-quality Enzyme-Linked Immunosorbent Assay (ELISA) and ELISpot assays. The company is a key player in the ELISpot market, offering comprehensive T cell and B cell solutions designed for the *ex vivo* detection and quantification of protein-secreting cells. U-CyTech’s core strength lies in its commitment to developing highly specific monoclonal and polyclonal antibodies which are then used in their assay kits, significantly enhancing the sensitivity and reliability required for advanced immunology research and diagnostics. Their products are instrumental in various research applications, including infectious diseases, autoimmune disorders, and vaccine development. They offer solutions for both the single-color ELISpot and multi-color FluoroSpot assays. By focusing intently on the quality and performance of its core reagents and offering specialized kits for a wide range of cytokines and species, U-CyTech enables researchers to achieve precise and reproducible results in their cellular immune monitoring studies, maintaining its reputation as a reliable specialist provider in the field.
\Sino Biological is a globally recognized leader in recombinant technology, providing a wide array of life science reagents and services, including high-quality ELISpot Assay Kits. The company has developed its ELISpot kits in-house, focusing on delivering unmatched sensitivity capable of detecting as few as one cell in a million, while maintaining minimal background for a high signal-to-noise ratio. Sino Biological is a key supplier supporting global efforts in vaccine development, infectious disease detection, drug screening, and tumor organoid research. Their offerings are designed to be user-friendly and reliable, featuring ready-to-use pre-coated plates that ensure consistent performance across experiments. By leveraging its expertise in recombinant protein technology, Sino Biological provides essential tools that allow researchers and diagnostic developers to accurately assess cellular immune responses, such as monitoring cytokine storms via IFN-γ, TNF-α, and IL-2 detection. Their commitment to high manufacturing standards, including ISO 9001 quality system compliance, reinforces their standing as a valuable resource in the ELISpot market.
\Precision for Medicine is a specialized organization providing comprehensive support for clinical trials, with a strong offering in the highly sensitive ELISpot and FluoroSpot assays to monitor cell-mediated immune responses. The company’s specialty lab scientists offer these testing services globally to support preclinical and clinical projects, including complex multi-site studies. Precision offers both pre-validation and validation services using standard and custom assays, which is critical for regulated studies in the biopharmaceutical industry. Beyond just running the assays, Precision provides a consultative approach, helping researchers develop optimal biomarker assay strategies. A key differentiator is their ability to integrate biomarker assay data with broader clinical trial data using their proprietary QuartzBio Translational Informatics platform, offering a deeper understanding of immune responses in the context of other clinical endpoints. This holistic approach, combined with their global reach and range of additional lab services like flow cytometry and cytokine profiling, positions Precision for Medicine as a key service provider for complex cellular immunology and biomarker screening in drug development.
\Abcam Limited is a globally recognized supplier of validated biological reagents and assays, playing an important role in the ELISpot assay market primarily as a provider of kits and reagents. While their primary focus spans across antibodies, proteins, and immunoassays, their catalog includes ELISpot kits for the measurement of various human and mouse cytokines, such as IL-1beta. Researchers frequently utilize Abcam’s products for measuring cytokine release and performing other cell-mediated immunity studies. The company’s commitment to product quality and extensive validation, often cited in peer-reviewed publications, makes their ELISpot-related offerings a dependable choice for academic, pharmaceutical, and biotech laboratories worldwide. Abcam’s large, diverse portfolio supports a broad range of life science research applications, ensuring that investigators have access to the necessary components and kits to successfully perform the sensitive ELISpot assay for applications like infectious disease, inflammation research, and cancer immunology, solidifying their position as a major resource for ELISpot consumables.
\Oxford Immunotec, a subsidiary of Revvity, Inc., is a key company in the ELISpot assay market, recognized as one of the pioneers in applying this technology for commercial diagnostics and clinical use. Their significant contribution is the T-SPOT.TB test, a critical application of the ELISpot principle for diagnosing latent and active tuberculosis infection by detecting T cells that secrete IFN-gamma in response to TB-specific antigens. This high-profile diagnostic product demonstrates the company’s deep expertise in translating sensitive ELISpot technology into robust, commercially successful, and clinically approved assays. Furthermore, Oxford Immunotec is listed among the key companies in the broader ELISpot and FluoroSpot assay market reports, particularly noted for introducing advanced ELISpot kits designed specifically for vaccine development, highlighting their continued innovation and focus on high-strength immune-monitoring assays post-COVID-19. Their commercial success in diagnostics has cemented the ELISpot assay’s relevance in clinical practice, alongside its traditional role in research.
\Creative Biolabs is a comprehensive Contract Research Organization (CRO) and service provider that offers specialized ELISpot Assay services to support the R\&D projects of pharmaceutical and biotechnology clients. With over a decade of experience, the company is proficient in performing both T cell and B cell ELISpot assays, including the ability to analyze a single cytokine or a combination of multiple cytokines. Creative Biolabs utilizes cutting-edge technologies to facilitate research in critical areas such as cancer, infectious diseases, autoimmune disorders, and AIDS. Their services include the use of commercially available or custom-developed assays, along with validation services to ensure regulatory compliance. They are skilled at quantifying cytokine-producing cells (like CD4+ and CD8+ T cells) and determining the specific antibody isotype produced by antigen-specific B cells. By offering customized B-cell and T-cell ELISpot assays and providing consulting tips for test maximization, Creative Biolabs serves as a valuable outsourced partner for complex cellular immunity and immunogenicity studies.
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