DNA Sequencing In Drug Discovery: Market outlook for applications, tools and services, and 40 company profiles

Report Description:

The advent of DNA sequencing technology has had a vast impact on the field of drug development. It has played a key role in the success of the Human Genome Project which has made it an essential tool for genetic analysis. Advanced technological developments in microarrays, bioinformatics and similar tools have increased the scope of applications and services. 

This report covers regional markets, products and services while evaluating them over the next five years, and profiles almost 40 companies involved in the DNA sequencing market.

Key features of this report

• It analyzes the market data ( revenues ) of DNA sequencing tools and services in North America, Europe, Asia and rest of the world that includes Middle East, Africa, Russia, Latin America and Australia.
• Key market drivers and restraints for the parent segments and evaluation of respective sub segments with respect to market dynamics.
• Covers microarray, DNA sequencing kits, chromatography, mass spectrometry, DNA amplification and many others within the tools market along with their sub segments. The services market includes high throughput sequencing , shot gun sequencing , re-sequencing, sample process and primer walking, single pass analysis and bacterial identification. 

Scope of this report

• Understand the emerging technologies and the growth associated for evaluation of potential of the type of products and services.
• Understanding the product developments on which companies are focusing to evaluate new technological trends.
• For evaluation of growth prospective for DNA sequencing applications and determining lucrative markets.

Key Market Issues

• Funding from public institutes is encouraging market players to focus on the development of the DNA sequencing technology.
• The withdrawal of certain drugs from the market due to their lack of efficacy among the worldwide patient population has created a need to address variations in diseases and drug responses on an individual basis.
• Next generation sequencing may hinder the growth of the market for first-generation DNA sequencing technology especially in the drug discovery and development sector.

Key findings from this report

• The DNA sequencing market growth is highest in the Asian and North American region, with Europe having the second largest market.
• North America constitutes the major market share with next-generation sequencing attracting the new participants in the region.
• The existing market participants are strategically positioning their DNA sequencing technologies by differentiating the specificity of the type of their tools and services.
• Agilent Technologies, CLC Bio, and Life Technologies Corporation are some of the major DNA sequencing companies engaged in collaborative partnerships in the past couple of years.

Key questions answered

• What are the important DNA sequencing markets and their growth over the period 2009-14?
• What are the major technologies and services that have emerged in different areas such as microarray, PCR, re-sequencing, high throughput sequencing?
• In which areas are the companies focusing while forming strategic alliances with other market players?
• What is the current potential of DNA sequencing applications with respect to drug development and discovery?

Table of Contents

• DNA Sequencing in Drug Discovery

Executive summary 14

• Market overview 14
• Market dynamics 15
• Global DNA sequencing tools & services market 16
• Company profiles 17

Chapter 1 Market overview 20

• Summary 20
• Evolution of DNA sequencing 21
  
• DNA sequencing and drug discovery 22
  
• Defining the market 24
  
  • Need for more reliable and compatible tools 24
  • High throughput and next-generation sequencing – attractive growth factors 25
  • DNA sequencing tools dominate the market 26
  • Protecting DNA sequencing technology 28
  • Applications of DNA sequencing 30
  • Drug development 31
• Clinical trials 32
  
  • Whole genome testing 32
  • Toxicology prediction 32
  • Identification of drug resistance 32
  • Drug discovery 33

Chapter 2 Market dynamics 36

• Summary 36
  
• Introduction 37
  
• Regional markets 37
  
  • North America 38
  • Europe 39
  • Asia 39
  • RoW 39
• Competitive landscape 40
• Recent agreements and collaborations 42
• Recent launches 44
• Market drivers 49
  
  • Funding from public institutes 49
  • NGS technologies 49
  • Patient profiling for genetic disorders 49
  • Development of personalized medicine 50
  • High productivity rates 50
• Market restraints 50
  
  • Shift in sequencing market trends 50
  • Introduction of NGS technologies 50

Chapter 3 Global DNA sequencing tools & services market 54

• Summary 54
  
  • DNA sequencing tools 55
  • Microarray 56
  • Biochip microarray 58
  • Gel array 58
  • Array design kit 59
  • Low and high density microarrays 60
  • Bioinformatics 60
  • Electrophoresis 62
  • Gel electrophoresis 63
  • Capillary electrophoresis 64
  • DNA sequencing kits 64
  • Consumables, chemicals, reagents and probes 65
  • DNA polymerase 66
  • Primers 67
  • Automated DNA sequencers 68
  • Chromatography 69
  • DNA amplification (PCR) 70
  • Mass spectrometry 71
  • Microscopy-based techniques 71
  • Electron microscopy 72
  • Atomic force microscopy 73
  • Microfluidics-enabled workstations 74
  • Barcode readers for DNA sample presentation 74
  • Computational chemistry and biology modeling 75
  • Spotters/arrayers 76
  • Centrifuge 77
  • Scanners 78
  • Thermal cyclers 78
  • Charge-coupled devices (CCDs) 79
  • Plates, strips and columns 80
  • DNA sequencing services 81
  • High throughput sequencing 82
  • Shotgun sequencing 83
  • Re-sequencing 83
  • Sample process and primer walking 84
  • Single pass analysis 85
  • Bacterial identification 86
• Market drivers 87
  
  • Microarray technology is a powerful tool for high throughput screening 87
  • Increasing applications of microarrays 87
  • Increasing applications of bioinformatics in R&D 88
  • Technological breakthroughs generate need for efficient DNA sequencing 88
  • Genomics and drug discovery applications of automated sequencers 88
  • Diagnostic applications of automated sequencers 89
  • Applications in comparative research projects of automated sequencers 89
  • Developments in PCR technology 89
  • PCR is a reliable tool for multiple applications 89
  • Government initiative for funding 90
• Market restraints 90
  
  • Limited scope of microarrays for pathogen enumeration 90
  • Time loss due to large number of laboratory specific variations for microarrays 90
  • Low cost next-generation technologies hinder growth of microarrays 90
  • Incompatibility issues of current bioinformatics tools 91
  • High cost of modifying supporting products 91
  • High cost and reliability issues of PCR technology 91

Chapter 4 Company profiles 94

• Summary 94
  
• 454 Life Sciences 95
  
  • Company overview 95
  • Products and services 95
  • Company strategy 95
  • Other events 96
• Affymetrix 97
  
  • Company overview 97
  • Product and services 98
  • Company strategy 98
• Agilent Technologies 99
  
  • Company overview 99
  • Products and services 99
  • Company strategy 99
• Beckman Coulter, Inc 100
  
  • Company overview 101
  • Products and services 101
  • Company strategy 101
• Bio-Rad Laboratories 102
  
  • Company overview 102
  • Products and services 102
  • Company strategy 102
• Caliper Life Sciences 103
  
  • Company overview 104
  • Products and services 104
  • Company strategy 104
• CapitalBio Corp. 105
  
  • Company overview 105
  • Products and services 105
  • Company strategy 105
• CombiMatrix Corp. 106
  
  • Company overview 107
  • Products and services 107
  • Company strategy 107
• Commonwealth Biotechnologies, Inc 108
  
  • Company overview 108
  • Products and services 108
  • Company strategy 108
• Complete Genomics, Inc 109
  
  • Company overview 109
  • Products and services 109
  • Company strategy 109
• DNA Vision 110
  
  • Company overview 110
  • Products and services 111
  • Company strategy 111
• Enzo Biochem, Inc 111
  
  • Company overview 111
  • Products and services 112
  • Company strategy 112
• EPICENTRE Biotechnologies 112
  
  • Company overview 112
  • Products and services 113
  • Company strategy 113
• Eurofins MWG Operon 113
  
  • Company overview 113
  • Products and services 114
  • Company strategy 114
• GE Healthcare 115
  
  • Company overview 115
  • Products and services 115
  • Company strategy 116
• Gen-Probe Life Sciences 116
  
  • Company overview 117
  • Products and services 117
  • Company strategy 117
• GVK Biosciences (GVK BIO) 118
  
  • Company overview 118
  • Products and services 119
  • Company strategy 119
• Helicos BioSciences Corp. 120
  
  • Company overview 120
  • Products and services 120
  • Company strategy 120
• Illumina, Inc 121
  
  • Company overview 121
  • Products and services 122
  • Company strategy 122
• Integrated DNA Technologies 123
  
  • Company overview 123
  • Products and services 123
  • Company strategy 123
• Kapa Biosystems, Inc 124
  
  • Company overview 125
  • Products and services 125
  • Company strategy 125
• Life Technologies Corp. 126
  
  • Company overview 126
  • Products and services 126
  • Company strategy 126
• Microchip Biotechnologies, Inc 127
  
  • Company overview 127
  • Products and services 127
  • Company strategy 127
• Nanogen, Inc 128
  
  • Company overview 128
  • Products and services 128
  • Company strategy 129
• Ocimum Biosolutions Ltd. 130
  
  • Company overview 130
  • Products and services 130
  • Company strategy 130
• Pacific Biosciences 131
  
  • Company overview 131
  • Company strategy 131
• PamGene 132
  
  • Company overview 132
  • Products and services 132
  • Company strategy 133
• Promega Corp. 133
  
  • Company overview 133
  • Products and services 134
  • Company strategy 134
• QIAGEN 136
  
  • Company overview 136
  • Products and services 137
  • Company strategy 137
• Sequenom 138
  
  • Company overview 138
  • Products and services 138
  • Company strategy 139
• Shimadzu Biotech 140
  
  • Company overview 140
  • Products and services 141
  • Company strategy 141
• Siemens Healthcare Diagnostics 141
  
  • Company overview 142
  • Products and services 142
  • Company strategy 142
• Sigma-Aldrich 143
  
  • Company overview 143
  • Products and services 144
  • Company strategy 144
• SoftGenetics, LLC. 144
  
  • Company overview 145
  • Products and services 145
  • Company strategy 145
• Thermo Fisher Scientific, Inc 146
  
  • Company overview 146
  • Products and services 147
  • Company strategy 147
• Third Wave Technologies, Inc 148
  
  • Company overview 148
  • Products and services 148
  • Company strategy 148
• VisiGen Biotechnologies 149
  
  • Company overview 149
  • Products and services 150
  • Company strategy 150
• ZS Genetics 150
  
  • Company overview 151
  • Products and services 151
  • Company strategy 151