Epidemiology: Sepsis

Severe sepsis is a prominent infectious syndrome in the seven major markets, especially in intensive care units. Datamonitor estimates that in 2010, there were around 1.1 million incident cases of severe sepsis in the seven major markets; this is expected to increase to approximately 1.3 million incident cases by 2020.Gain insight to market potential, including a robust 10-year epidemiology forecast of severe sepsis incident cases.Understand the key epidemiologic risk factors associated with severe sepsis.Datamonitor estimates that the number of incident cases of severe sepsis in the seven major markets will increase by 1.7% on average each year between 2010 and 2020. The highest average annual increases are forecasted to be in the US (2.0%) and Japan (1.9%) and the smallest average annual increases will be in Germany, Spain, and the UK (1.2% each).The incidence of severe sepsis is on the rise in the seven major markets (the US, Japan, France, Germany, Italy, Spain, and the UK). The driving risk factor behind this increase in the yearly incidence of severe sepsis is that the population over the age of 60, which has the highest incidence of sepsis, is growing in all seven markets.What are the most robust sources for severe sepsis incidence data?How will the patient population change over the next decade in the US, Japan, and five major EU markets (France, Germany, Italy, Spain, and the UK)?How do changes in population structure and risk factors affect the trend in incident severe sepsis cases?

Executive Summary
Disease background
Epidemiologic forecasting
OVERVIEW
Catalyst
Summary
DISEASE DEFINITION AND DIAGNOSIS CRITERIA
Clinical definition and diagnosis criteria
GLOBAL VARIATION AND HISTORICAL TRENDS
Global variation
Historical trends
Morbidity and mortality of sepsis
Morbidity
Mortality
RISK FACTORS
Age
Race
Hospitalization
Genetics
CO-MORBIDITIES
Chronic obstructive pulmonary disorder
Congestive heart failure
Cancer
Chronic liver disease and cirrhosis
Complicated diabetes
Autoimmune disease/HIV
EPIDEMIOLOGIC FORECASTING
Sources of epidemiologic data and methods
US
Japan
France
Germany
Italy
Spain
UK
EPIDEMIOLOGIC RESULTS
Current prevalent cases and future trends
Annual growth rate of disease population
DISCUSSION
Strengths and limitations of Datamonitor’s epidemiologic projections
BIBLIOGRAPHY
Journal papers
Datamonitor reports
APPENDIX
Module methodology