Table of Contents
Table of Contents 2
List of Tables 4
List of Figures 4
Introduction 5
Global Markets Direct Report Coverage 5
Portal Hypertension Overview 6
Therapeutics Development 7
Pipeline Products for Portal Hypertension - Overview 7
Portal Hypertension - Therapeutics under Development by Companies 8
Portal Hypertension - Pipeline Products Glance 9
Clinical Stage Products 9
Early Stage Products 10
Portal Hypertension - Products under Development by Companies 11
Portal Hypertension - Companies Involved in Therapeutics Development 12
Conatus Pharmaceuticals Inc. 12
Cumberland Pharmaceuticals, Inc. 13
Galectin Therapeutics, Inc. 14
Genextra S.p.a. 15
LinXis B.V. 16
Mezzion Pharma Co. Ltd. 17
Portal Hypertension - Therapeutics Assessment 18
Assessment by Monotherapy Products 18
Assessment by Target 19
Assessment by Mechanism of Action 21
Assessment by Route of Administration 23
Assessment by Molecule Type 25
Drug Profiles 27
emricasan - Drug Profile 27
Product Description 27
Mechanism Of Action 27
R&D Progress 27
GRMD-02 - Drug Profile 33
Product Description 33
Mechanism Of Action 33
R&D Progress 33
ifetroban sodium - Drug Profile 44
Product Description 44
Mechanism Of Action 44
R&D Progress 44
LIN-003 - Drug Profile 46
Product Description 46
Mechanism Of Action 46
R&D Progress 46
obeticholic acid - Drug Profile 47
Product Description 47
Mechanism Of Action 47
R&D Progress 47
udenafil - Drug Profile 57
Product Description 57
Mechanism Of Action 57
R&D Progress 57
Portal Hypertension - Dormant Projects 60
Portal Hypertension - Discontinued Products 61
Portal Hypertension - Product Development Milestones 62
Featured News & Press Releases 62
Oct 20, 2015: Conatus Pharmaceuticals Announces Acceptance of Late-Breaking Abstract for AASLD Annual Meeting 62
ep 23, 2015: Conatus Announces Top-line Results From Multicenter Phase 2 Portal Hypertension Clinical Trial in Patients With Liver Cirrhosis 62
Nov 10, 2014: Conatus Pharmaceuticals Presents Late-Breaking Poster At AASLD Annual Meeting 64
Oct 08, 2014: Conatus Pharmaceuticals Announces Acceptance Of Late-Breaking Abstract For AASLD Annual Meeting 65
Sep 02, 2014: Conatus Pharmaceuticals Initiates Phase 2 Trial in Patients with Liver Cirrhosis and Separate Open Label Phase 2 Trial in Cirrhosis Patients with Portal Hypertension 65
Nov 08, 2012: Intercept Pharma To Present Phase IIa Portal Hypertension Data At AASLD''s Annual Liver Meeting 66
Appendix 68
Methodology 68
Coverage 68
Secondary Research 68
Primary Research 68
Expert Panel Validation 68
Contact Us 68
Disclaimer 69
List of Tables
Number of Products under Development for Portal Hypertension, H2 2016 7
Number of Products under Development by Companies, H2 2016 8
Comparative Analysis by Clinical Stage Development, H2 2016 9
Comparative Analysis by Early Stage Development, H2 2016 10
Products under Development by Companies, H2 2016 11
Portal Hypertension - Pipeline by Conatus Pharmaceuticals Inc., H2 2016 12
Portal Hypertension - Pipeline by Cumberland Pharmaceuticals, Inc., H2 2016 13
Portal Hypertension - Pipeline by Galectin Therapeutics, Inc., H2 2016 14
Portal Hypertension - Pipeline by Genextra S.p.a., H2 2016 15
Portal Hypertension - Pipeline by LinXis B.V., H2 2016 16
Portal Hypertension - Pipeline by Mezzion Pharma Co. Ltd., H2 2016 17
Assessment by Monotherapy Products, H2 2016 18
Number of Products by Stage and Target, H2 2016 20
Number of Products by Stage and Mechanism of Action, H2 2016 22
Number of Products by Stage and Route of Administration, H2 2016 24
Number of Products by Stage and Molecule Type, H2 2016 26
Portal Hypertension - Dormant Projects, H2 2016 60
Portal Hypertension - Discontinued Products, H2 2016 61
List of Figures
Number of Products under Development for Portal Hypertension, H2 2016 7
Number of Products under Development by Companies, H2 2016 8
Comparative Analysis by Clinical Stage Development, H2 2016 9
Assessment by Monotherapy Products, H2 2016 18
Number of Products by Top 10 Targets, H2 2016 19
Number of Products by Stage and Top 10 Targets, H2 2016 19
Number of Products by Top 10 Mechanism of Actions, H2 2016 21
Number of Products by Stage and Top 10 Mechanism of Actions, H2 2016 21
Number of Products by Routes of Administration, H2 2016 23
Number of Products by Stage and Routes of Administration, H2 2016 23
Number of Products by Molecule Types, H2 2016 25
Number of Products by Stage and Molecule Types, H2 2016 25