Table of Contents
Table of Contents 2
List of Tables 4
List of Figures 5
Introduction 6
Global Markets Direct Report Coverage 6
Osteonecrosis Overview 7
Therapeutics Development 8
Pipeline Products for Osteonecrosis - Overview 8
Osteonecrosis - Therapeutics under Development by Companies 9
Osteonecrosis - Pipeline Products Glance 10
Late Stage Products 10
Clinical Stage Products 11
Early Stage Products 12
Osteonecrosis - Products under Development by Companies 13
Osteonecrosis - Companies Involved in Therapeutics Development 14
Bone Therapeutics SA 14
Enzo Biochem, Inc. 15
K-Stemcell Co., Ltd. 16
Osteonecrosis - Therapeutics Assessment 17
Assessment by Monotherapy Products 17
Assessment by Target 18
Assessment by Mechanism of Action 20
Assessment by Route of Administration 22
Assessment by Molecule Type 24
Drug Profiles 26
ALLOB - Drug Profile 26
Product Description 26
Mechanism of Action 26
R&D Progress 26
CGS-200 - Drug Profile 28
Product Description 28
Mechanism of Action 28
R&D Progress 28
LWnt-3a - Drug Profile 29
Product Description 29
Mechanism of Action 29
R&D Progress 29
PREOB - Drug Profile 30
Product Description 30
Mechanism of Action 30
R&D Progress 30
Small Molecule to Agonize LRP for Osteonecrosis Of Jaws - Drug Profile 31
Product Description 31
Mechanism of Action 31
R&D Progress 31
Stem Cell Therapy for Musculoskeletal, CNS Disorders, Dermatology, Immunology and Cardiovascular Disease - Drug Profile 32
Product Description 32
Mechanism of Action 32
R&D Progress 32
Osteonecrosis - Recent Pipeline Updates 34
Osteonecrosis - Dormant Projects 39
Osteonecrosis - Product Development Milestones 40
Featured News & Press Releases 40
May 03, 2016: Bone Therapeutics completes recruitment of its ALLOB® Phase IIA spinal fusion study 40
Nov 30, 2015: CapGenesis Files Five Orphan Drug Designation Requests with the FDA and EMA for CGS-200 as a Topical Analgesic 40
Dec 04, 2014: Bone Therapeutics Authorised to Enrol Patients in the UK in Pivotal Phase III Osteonecrosis Trial with PREOB 41
Nov 07, 2013: Bone Therapeutics'' pivotal phase III osteonecrosis trial with PREOB hits a new milestone 42
Jan 28, 2013: Bone Therapeutics Raises €1.6m In Grant Subsidies From SRIW And Sambrinvest For Autologous Bone Cell Therapy 43
Oct 15, 2012: Bone Therapeutics Receives Clearance For Pivotal Phase III Osteonecrosis Trial With Preob In Europe And Treats The First Patients In Study 43
Appendix 44
Methodology 44
Coverage 44
Secondary Research 44
Primary Research 44
Expert Panel Validation 44
Contact Us 44
Disclaimer 4
List of Tables
Number of Products under Development for Osteonecrosis, H1 2016 8
Number of Products under Development by Companies, H1 2016 9
Comparative Analysis by Late Stage Development, H1 2016 10
Comparative Analysis by Clinical Stage Development, H1 2016 11
Comparative Analysis by Early Stage Development, H1 2016 12
Products under Development by Companies, H1 2016 13
Osteonecrosis - Pipeline by Bone Therapeutics SA, H1 2016 14
Osteonecrosis - Pipeline by Enzo Biochem, Inc., H1 2016 15
Osteonecrosis - Pipeline by K-Stemcell Co., Ltd., H1 2016 16
Assessment by Monotherapy Products, H1 2016 17
Number of Products by Stage and Target, H1 2016 19
Number of Products by Stage and Mechanism of Action, H1 2016 21
Number of Products by Stage and Route of Administration, H1 2016 23
Number of Products by Stage and Molecule Type, H1 2016 25
Osteonecrosis Therapeutics - Recent Pipeline Updates, H1 2016 34
Osteonecrosis - Dormant Projects, H1 2016 39
List of Figures
Number of Products under Development for Osteonecrosis, H1 2016 8
Number of Products under Development by Companies, H1 2016 9
Assessment by Monotherapy Products, H1 2016 17
Number of Products by Targets, H1 2016 18
Number of Products by Stage and Targets, H1 2016 18
Number of Products by Mechanism of Actions, H1 2016 20
Number of Products by Stage and Mechanism of Actions, H1 2016 20
Number of Products by Routes of Administration, H1 2016 22
Number of Products by Stage and Routes of Administration, H1 2016 22
Number of Products by Molecule Types, H1 2016 24
Number of Products by Stage and Molecule Types, H1 2016 24