Japan Market Report for Anti-Adhesion Products - MedCore

Published: June 2016
No. of Pages: 29

The anti-adhesion market, also referred to as the adhesion prevention market, includes products aimed at
minimizing surgical adhesions. Surgical adhesions are fibrous bands that form between tissues and organs,
often as a result of injury during surgery. These adhesions can be formed during any type of surgery,
including gynecological, abdominal, orthopedic, cardiac and neurological procedures.

Adhesions are often
thought of as internal scar tissue and are a side effect of the body’s natural healing process. For example,
up to 93% of patients who undergo intra-abdominal surgery develop adhesions. The majority of adhesions
are asymptomatic; however, approximately 5% of adhesions result in severe symptoms such as pain, small
bowel obstruction (SBO), range of motion restriction and/or infertility. While only 5% of adhesions result
in symptoms severe enough to require further treatment, as many as 30% are thought to cause low level
discomfort that is tolerated by the patient. Adhesions are believed to be responsible for approximately
65% of all SBO, 35% of chronic pelvic pain and 20% of infertility diagnoses.
There are a number of different methods that surgeons use to reduce the incidence of adhesions. The most
effective way is to perform laparoscopic procedures whenever possible, as they carry a much lower risk of
symptomatic adhesion formation. In addition, surgeons attempt to minimize tissue necrosis, providing
meticulous hemostasis, liberally irrigating the abdominal cavity and using non-reactive suture materials.
In some situations, drugs that inhibit the inflammatory response, such as corticosteroids, non-steroidal
anti-inflammatory, pentoxifylline and calcium channel blockers have been used. However, the most
effective method of reducing adhesions has been determined to be the use of adhesion barriers.
The first of currently used products entered the market in 1989 and was made out of oxidized regenerated
cellulose (ORC). It is absorbed within four weeks of application. Seprafilm® by Genzyme consists of
sodium hyaluronate and carboxymethylcellulose, forming a film that becomes a hydrated gel 24 to 48
hours after placement.



Published By: iData Research
Product Code: iData Research1738

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