Downstream Processing in Biopharmaceuticals - Increased Demand for Biologics Drives Improvement in Cost -effective Purification Technologies

Downstream Processing in Biopharmaceuticals - Increased Demand for Biologics Drives Improvement in Cost -effective Purification Technologies

Summary

GBI Research's report, “Down Stream Processing in Biopharmaceuticals - Increased Demand for Biologics Drives Improvement in Cost-effective Purification Technologies”, provides the key data and analyzes the major challenges and drivers for the downstream industry. The report also analyzes the strengths, weaknesses of and opportunities for the stakeholders in the downstream processing of biopharmaceuticals. The report also discusses the key market drivers and barriers for the growth of biomanufacturing in the pharmaceutical and biotech industry. The report is based on proprietary databases, primary and secondary research and in-house analysis by GBI Research’s team of industry experts to provide a comprehensive view of the Down Stream Processing in Biopharmaceuticals.

Scope

The scope of this report includes:
- Opportunities and challenges for manufacturers of Biopharmaceuticals in the pharmaceuticals industry
- Market revenues and forecasts for Down Stream Processing in the global pharmaceutical industry from 2009 to 2016.
- The key geographies including the US, Europe, Japan and Emerging Hotspots such as India, Singapore and China.
- Downstream bioprocess involves detailed technological development and possible development in near future.
- Technology trends in downstream bioprocess that shape the biomanufacturing industry
- Qualitative analysis of the market drivers, barriers, future outlook and challenges for the downstream bioprocess.
- Analysis of competitive landscape and the leading market players.

Reasons to buy

- Formulate strategies to increase your company’s growth by understanding the new growth opportunities in the downstream market.
- Work around the technology hurdles by identifying the key trends shaping and driving the market for downstream bioprocess.
- Differentiate yourself from competitors and develop new solutions for the biomanufacturing industry by understanding the current competitive landscape and how it is evolving to meet the increasing demands
- Draft efficient strategies by understanding best practices, identifying key winners and losers and who is best positioned to take advantage of the emerging market opportunities

1 Table of Contents 3
1.1 List of Tables 5
1.2 List of Figures 6
2 Downstream Processing: Introduction 8
2.1 GBI Research Report Guidance 8
3 Downstream Processing – Market Overview 9
3.1 Overview of Biopharmaceuticals 9
3.1.1 Cytokines 9
3.1.2 Enzymes 9
3.1.3 Hormones 9
3.1.4 Clotting Factors 9
3.1.5 Vaccines 10
3.1.6 Monoclonal Antibodies 10
3.1.7 Cell Therapies 10
3.1.8 Antisense Drugs 10
3.1.9 Peptide Therapeutics 10
3.2 Overview of Downstream Processing in Biopharmaceuticals 12
3.2.1 A Typical Downstream Processing: 13
3.2.2 Major Check Point during Down Stream Processing 14
3.3 Overview of Downstream Industry 15
4 Downstream Processing : Role of Downstream Processing in the Biopharmaceutical Industry 16
4.1 Comparison of Upstream Processing and Downstream Processing 18
4.2 Major Reagents, Reagent Suppliers and Reagent Market Related To Downstream Processing 19
4.2.1 Major Reagents 19
4.2.2 Reagent Suppliers 20
4.2.3 Reagent Market 22
4.3 Major Equipment Suppliers 26
5 Downstream Processing: Downstream Processing Market for CMOs 27
5.1 Global CMO Market Overview 27
5.2 CMO Biopharmaceuticals Market Characterization 27
5.3 CMO Market Size for Downstream Processing 29
6 Downstream Processing : Challenges and Unmet Needs in Downstream Bioprocess 30
6.1 Challenges 30
6.1.1 Chromatographic Capture 30
6.1.2 Reducing the Purification Steps 30
6.1.3 Titer increment /Capacity Bottleneck 31
6.1.4 Virus Clearances 31
6.1.5 Scaling –Up 31
6.2 Unmet Needs 32
6.2.1 Unmet Medical Needs 32
6.2.2 Realistic Achievement of Economies of Scale 33
6.2.3 Technological Development of Disposables at Large Scale 34
6.2.4 Reagent Cost and Their Effectiveness 35
7 Downstream Processing : Emerging Technologies and their Implication 36
7.1 Disposable Technology / Single Use Technology 36
7.1.1 Use of Single Use Technology in Downstream Operations 39
7.1.2 Major Benefits of Single use Technology 40
7.1.3 Major Challenges in Single Use Technology 41
7.1.4 Some Recent Products Developed By Major Firms 42
7.2 Membrane Chromatography 42
7.3 Multi-Column Chromatography 44
7.3.1 Advantages 44
7.3.2 Drawbacks 44
7.3.3 Applications 45
7.4 Aqueous Two Phase System 45
7.5 Tangential Flow Filtration 45
7.5.1 Tangential Flow Filtration Applications 46
7.5.2 Few Products Developed By Major Firms 47
7.6 Monoliths 47
7.7 Expanded-Bed Adsorption (EBA) Chromatography 47
7.7.1 Applications 48
7.8 Mixed-Mode Chromatography 48
8 Downstream Processing : Industry Analysis 50
8.1 Key Drivers and Restraints 50
8.1.1 Key Drivers of Downstream Processing Market 50
8.1.2 Key Restraints of Downstream Processing Market 51
8.2 Porter Five Forces Model for Industry Analysis 52
8.3 Impact of Environmental Factors on the Industry 55
8.3.1 International Economy Impact 55
8.3.2 The Natural Environment Impact 55
8.3.3 Technological Impact 55
8.3.4 Political or Governmental Impact 55
8.3.5 Demographic Structure 56
8.3.6 Social Structure 56
8.4 Major Events and Their Impact Analysis 56
9 Downstream Processing: Competitive Landscape 57
9.1 Market Dynamics of Downstream Processing and Impact 57
9.1.1 Market Structure 57
9.1.2 Competitive Analysis of Major CMO Firms 58
9.1.3 Competitive Analysis of Equipment and Reagent Industry 59
9.2 Key Equipment Players 60
9.2.1 Pall Corporation 60
9.2.2 Milipore 63
9.2.3 Sartorius 66
9.2.4 3M Purification Inc. 69
9.3 Key Reagent Players 71
9.3.1 Life Technologies 71
9.3.2 Sigma Aldrich 74
9.3.3 SWOT Analysis 75
9.3.4 M&A Deals 75
9.4 Key CMO Players 77
9.4.1 Lonza 77
9.4.2 Boehringer Ingelheim 80
9.4.3 SWOT Analysis 81
9.4.4 Avecia Biotechnology 83
9.4.5 Diosynth Biotechnology 85
10 Downstream Processing : Appendix 88
10.1 Market Definitions 88
10.2 Abbreviations 88
10.3 Research Methodology 89
10.3.1 Coverage 89
10.3.2 Secondary Research 89
10.3.3 Primary Research 89
10.3.4 Expert Panel Validation 90
10.4 Contact Us 90
10.5 Disclaimer 90
10.6 Sources 91