Table of Contents
1 Table of contents 3
1.1 List of Tables 7
1.2 List of Figures 8
2 Disease Overview 11
2.1 Overview 11
2.1.1 TNM (Tumor, Nodes, Metastasis) Staging System 11
2.1.2 Jewett-Whitmore system 12
2.2 Epidemiology 12
2.3 Etiology 13
2.4 Symptoms 13
2.4.1 Localized or Locally Advanced Prostate Cancer 13
2.4.2 Metastatic Prostate Cancer 13
2.5 Diagnosis 14
2.5.1 Digital Rectal Examination 14
2.5.2 Prostate Specific Antigen Test 14
2.5.3 Transrectal Ultrasound 15
2.5.4 Prostate Biopsy 15
2.6 Pathology 15
2.6.1 Grading 15
2.7 Treatment 16
2.7.1 Watchful Waiting 16
2.7.2 Radiation therapy 16
2.7.3 Surgery 17
2.7.4 Hormone therapy 17
2.7.5 Chemotherapy Options 18
2.7.6 Other Treatments Being Studied 19
2.8 Treatment Guidelines 20
3 Market Characterization 21
3.1 BRIC (Brazil, Russia, India and China) 21
3.1.1 Market Size 21
3.1.2 Forecasts 26
3.2 Brazil 31
3.2.1 Market Size 31
3.2.2 Drivers and Restraints 36
3.2.3 Impact on the Market 37
3.2.4 Forecasts 38
3.2.5 Future Impact 43
3.3 Russia 44
3.3.1 Market Size 44
3.3.2 Drivers and Restraints 49
3.3.3 Impact on the Market 50
3.3.4 Forecasts 51
3.3.5 Future Impact 56
3.4 India 57
3.4.1 Market Size (2001-2009) 57
3.4.2 Drivers and Restraints 62
3.4.3 Impact on the Market 63
3.4.4 Forecasts (2010-2020) 64
3.4.5 Future Impact 69
3.5 China 70
3.5.1 Market Size (2001-2009) 70
3.5.2 Drivers and Restraints 75
3.5.3 Impact on the Market 76
3.5.4 Forecasts (2010-2020) 77
3.5.5 Future Impact 82
3.6 Key Takeaway 82
4 Competitor Assessment 83
4.1 Strategic Competitor Assessment 83
4.1.1 Overview 83
4.1.2 Benchmarking 83
4.1.3 Current Competitor Assessment 87
4.2 Product Profiles 89
4.2.1 Taxotere (docetaxel) 90
4.2.2 Casodex (Bicalutamide) 93
4.2.3 Zoladex (Goserelin) 97
4.2.4 Eligard (leuprolide acetate) 99
4.2.5 Lupron (Leuprolide acetate) 102
4.2.6 Firmagon (degarelix) 106
4.2.7 Novantrone (Mitoxantrone hydrochloride) 108
4.2.8 Emcyt (estramustine) 110
4.2.9 Trelstar (triptorelin) 111
4.2.10 Eulexin 112
4.2.11 Delestrogen 114
4.2.12 Gynodiol 115
4.2.13 Estrace tablet 116
4.2.14 Tace 117
4.2.15 Nilandrone 118
4.2.16 Premarin 119
5 Pipeline Assessment 120
5.1 Overview 120
5.2 Pipeline Analysis by Phase of Development 121
5.3 Pipeline by Mechanism of Action 122
5.4 Strategic Pipeline Assessment 123
5.4.1 Technology Trends Analytical Framework 123
5.5 Trends in Prostate Cancer Pipeline 124
5.5.1 More Clarity on the Origin of Prostate Cancer Will Help in Identifying Novel Targets for Prostate Cancer Drugs 124
5.5.2 Molecules with Novel Mechanism of Action Strengthening Prostate Cancer Pipeline 124
5.5.3 Failure of Key Molecules to Achieve Positive Results in Phase III Development 124
5.6 Partners in Research and Development 125
5.6.1 Licensing Agreements by Phase of Development 125
5.6.2 Licensing Agreements by Geography 128
5.6.3 Licensing Agreements: Technology Licensing Agreements in Prostate Cancer 128
5.7 Most Promising Drugs’ Profiles 129
5.7.1 Provenge (sipuleucel-T) 131
5.7.2 Jevtana (cabazitaxel) 132
5.7.3 Aflibercept (VEGF Trap) 133
5.7.4 Ipilimumab 135
5.7.5 Abiraterone Acetate (CB7630) 136
5.7.6 Zibotentan (ZD4054) 138
5.7.7 Sprycel (dasatinib) 139
5.7.8 MDV3100 141
5.8 Prostate Cancer Pipeline – Pre-clinical Phase 143
5.9 Prostate Cancer Pipeline – Phase I 145
5.10 Prostate Cancer Pipeline – Phase II 147
5.11 Prostate Cancer Pipeline – Phase III 154
5.12 Key Takeaway 156
6 Unmet Need and Target Product Profile 157
6.1 Unmet Need 159
6.1.1 Hormone-independent Metastatic Prostate Cancer Therapy 159
6.1.2 Hormone-dependent Metastatic Prostate Cancer Therapy 160
6.2 Opportunity for Target Product 161
6.3 Target Product Profile 163
6.3.1 Ideal Characteristics 163
6.3.2 Target Product Description 164
6.4 Key Takeaway 164
7 Strategic Assessment 165
7.1 Key Events Impacting the Future Market 165
7.2 Market Impact Analysis 166
7.3 Future Market Scenario 166
7.4 Company Analysis 168
7.4.1 Market Leadership 168
7.4.2 Future Players in the Market 168
7.5 Key Takeaway 169
8 Company Profiles 170
8.1 Sanofi-aventis 170
8.1.1 Business Description 170
8.1.2 Financial Overview 172
8.1.3 SWOT Analysis 172
8.1.4 Oncology Focus 177
8.2 Pfizer Inc. 178
8.2.1 Business Description 178
8.2.2 Financial Overview 179
8.2.3 SWOT Analysis 179
8.2.4 Oncology Focus 185
8.3 AstraZeneca 186
8.3.1 Business Description 186
8.3.2 Financial Overview 188
8.3.3 SWOT Analysis 188
8.3.4 Oncology Focus 192
8.4 Bristol-Myers Squibb 194
8.4.1 Business Description 194
8.4.2 Financial Overview 195
8.4.3 SWOT Analysis 195
8.4.4 Oncology Focus 200
8.5 Medivation 202
8.5.1 Business Description 202
8.5.2 SWOT Analysis 203
8.5.3 Oncology Focus 206
8.6 Takeda Pharmaceuticals 206
8.6.1 Business Description 206
8.6.2 SWOT Analysis 206
8.7 Dendreon Corporation 208
8.7.1 Business Description 208
8.7.2 SWOT Analysis 208
8.8 Johnson and Johnson 212
8.8.1 Business Description 212
8.8.2 SWOT Analysis 213
8.8.3 Oncology Focus 219
8.9 Auron Healthcare GmbH 220
8.9.1 Business Description 220
8.10 Oncogenex Pharmaceuticals, Inc. 221
8.10.1 Business Description 221
8.11 Agennix AG 221
8.11.1 Business Description 221
8.12 GTx, Inc. 221
8.12.1 Business Description 221
8.13 GlaxoSmithKline plc. 222
8.13.1 Business Description 222
8.13.2 Financial Overview 223
8.13.3 SWOT Analysis 223
8.13.4 Oncology Focus 229
9 M&A Analysis 231
9.1 Key Highlights 231
9.2 Key Deals’ Analysis 232
9.2.1 Johnson & Johnson Acquires Cougar Biotechnology 232
9.2.2 Endo Pharmaceuticals Acquires Indevus Pharmaceuticals 232
9.2.3 Tolmar Holding Acquires QLT USA from QLT 233
9.2.4 Biomarin Pharmaceutical to Acquire Lead therapeutics 233
9.2.5 Isis Pharmaceuticals Reacquires Rights to Cancer Drug from Eli Lilly & Co. 233
9.2.6 Quest PharmaTech Acquires Late-stage Immunotherapeutic Antibody Pipeline from Paladin Labs 233
9.2.7 VaxOnco Acquires Rights to Onyvax-P Cell Vaccine From Onyvax 233
9.2.8 GPC Biotech Merges with Agennix 233
9.2.9 Eli Lilly Acquires ImClone 234
9.2.10 BBM Holdings Acquires YM BioSciences 234
9.2.11 Sagent Pharmaceuticals Acquires Injectable Generic Drug Applications of Spectrum Pharmaceuticals 234
9.3 M&A Deals by Geography 235
9.4 M&A Deals by Deal Size 235
10 Appendix 236
10.1 Market Definitions 236
10.2 Abbreviations 236
10.3 Research Methodology 238
10.3.1 Coverage 238
10.3.2 Secondary Research 239
10.3.3 Forecasting 239
10.3.4 Primary Research 242
10.3.5 Expert Panel validation 242
10.3.6 Contact Us 242
10.3.7 Disclaimer 242
10.3.8 Sources 243
1.1 List of Tables
Table 1: Prostate Cancer Therapeutics Market, Global, Staging of the Prostate Cancer, 2010
Table 2: Prostate Cancer, Global, Age Related PSA Levels (ng/ml), 2010
Table 3: Prostate Cancer Therapeutics Market, BRIC, Sales Value ($m), 2001–2009
Table 4: Prostate Cancer Therapeutics Market, BRIC, Annual Cost of Therapy ($), 2001–2009
Table 5: Prostate Cancer Therapeutics Market, BRIC, Patient Volume, 2001–2009
Table 6: Prostate Cancer Therapeutics Market, BRIC, Treatment Usage Patterns, 2001–2009
Table 7: Prostate Cancer Therapeutics Market, BRIC, Sales Value ($m), 2009–2020
Table 8: Prostate Cancer Therapeutics Market, BRIC, Annual Cost of Therapy ($), 2009–2020
Table 9: Prostate Cancer Therapeutics Market, BRIC, Patient Volume (absolute), 2009–2020
Table 10: Prostate Cancer Therapeutics Market, BRIC, Treatment Usage Patterns, 2009–2020
Table 11: Prostate Cancer Therapeutics Market, Brazil, Sales Value ($m), 2001-2009
Table 12:Prostate Cancer Therapeutics Market, Brazil, Annual Cost of Therapy ($), 2001-2009
Table 13: Prostate Cancer Therapeutics Market, Brazil, Patient Volume ('000s), 2001-2009
Table 14:Prostate Cancer Therapeutics Market, Brazil, Treatment Usage Patterns ('000s), 2001-2009
Table 15:Prostate Cancer Therapeutics Market, Brazil, Sales Value ($m), 2009-2020
Table 16:Prostate Cancer Therapeutics Market, Brazil, Annual Cost of Therapy ($), 2009-2020
Table 17: Prostate Cancer, Brazil, Patient Volume ('000s), 2009-2020
Table 18: Prostate Cancer Therapeutics Market, Brazil, Treatment Usage Patterns ('000s), 2009-2020
Table 19: Prostate Cancer, Russia, Sales Value ($m), 2001-2009
Table 20: Prostate Cancer, Russia, Annual Cost of Therapy ($), 2001-2009
Table 21: Prostate Cancer, Russia, Patient Volume (Thousands), 2001-2009
Table 22: Prostate Cancer, Russia, Treatment Usage Patterns, 2001-2009
Table 23: Prostate Cancer, Russia, Sales Value ($m), 2009-2020
Table 24: Prostate Cancer, Russia, Annual Cost of Therapy ($), 2009-2020
Table 25: Prostate Cancer, Russia, Patient Volume (Thousands), 2009-2020
Table 26: Prostate Cancer, Russia, Treatment Usage Patterns, 2009-2020
Table 27: Prostate Cancer, India, Sales Value ($m), 2001-2009
Table 28: Prostate Cancer, India, Annual Cost of Therapy ($), 2001-2009
Table 29: Prostate Cancer, India, Patient Volume (Thousands), 2001-2009
Table 30: Prostate Cancer, India, Treatment Usage Patterns, 2001-2009
Table 31: Prostate Cancer, India, Sales Value ($m), 2009-2020
Table 32: Prostate Cancer, India, Annual Cost of Therapy ($), 2009-2020
Table 33: Prostate Cancer, India, Patient Volume (Thousands), 2009-2020
Table 34: Prostate Cancer, India, Treatment Usage Patterns, 2009-2020
Table 35: Prostate Cancer, China, Sales Value ($m), 2001-2009
Table 36: Prostate Cancer, China, Annual Cost of Therapy ($), 2001-2009
Table 37: Prostate Cancer, China, Patient Volume (Thousands), 2001-2009
Table 38: Prostate Cancer, China, Treatment Usage Patterns, 2001-2009
Table 39: Prostate Cancer, China, Sales Value ($m), 2009-2020
Table 40: Prostate Cancer, China, Annual Cost of Therapy ($), 2009-2020
Table 41: Prostate Cancer, China, Patient Volume (Thousands), 2009-2020
Table 42: Prostate Cancer, China, Treatment Usage Patterns, 2009-2020
Table 43: Prostate Cancer, Global, Clinical Endpoints for Benchmarking, 2010
Table 44: Prostate Cancer, Global, Chemotherapy, Safety Profile of Standard Care Treatment, 2010
Table 45: Prostate Cancer, Global, Hormone Therapy, Safety Profile of Standard Care Treatment, 2010
Table 46: Prostate Cancer, BRIC, Benchmarking Major Marketed Products, 2010
Table 47: Prostate Cancer, Global, Casodex, Incidence of Adverse Effects, 2010
Table 48: Prostate Cancer, Global, Eligard, Effect on PSA Level, 2010
Table 49: Prostate Cancer, Global, Eligard, Incidence of Adverse Effects, 2010
Table 50: Prostate Cancer, Global, Eligard, Regulatory Approval by Region
Table 51: Prostate Cancer, Global, Lupron, Efficacy End Point for Three Products
Table 52: Prostate Cancer, Global, Lupron, Incidence of Adverse Effects, 2010
Table 53: Prostate Cancer, Global, Licensing Agreements, 2009-2010
Table 54: Prostate Cancer, Global, Technology Licensing Agreements Description, 2010
Table 55: Prostate Cancer, Global, Most Promising Drugs Under Clinical Development, 2010
Table 56: Prostate Cancer, Global, Pre-clinical Phase Pipeline, August 2010
Table 57: Prostate Cancer, Global, Phase I Pipeline, August 2010
Table 58: Prostate Cancer, Global, Phase II Pipeline, August 2010
Table 59: Prostate Cancer, Global, Phase III Pipeline, August 2010
Table 60: Prostate Cancer, Global, Characteristics of Ideal Drug Which Satisfies the Unmet Needs of the Market, 2010
Table 61: Prostate Cancer, Global, Description of Ideal Drug Which Satisfies the Unmet Needs of the Market, 2010
Table 62: Prostate Cancer, Johnson & Johnson, Oncology Late Stage Pipeline by Indication, 2010
Table 63: Prostate Cancer, Global, Auron Healthcare, Key Pipeline Products, 2010
Table 64: Prostate Cancer, Global, M&A Deals by Geography, 2010
1.2 List of Figures
Figure 1: Prostate Cancer Therapeutics Market, BRIC, Sales Value ($m), 2001-2020
Figure 2: Prostate Cancer Therapeutics Market, Global, Pipeline by Mechanism of Action (%), 2010
Figure 3: Prostate Cancer Therapeutics Market, BRIC, Hormone-Independent Metastatic Prostate Cancer, Opportunity and Unmet Need, 2010
Figure 4: Prostate Cancer Therapeutics Market, Global, Treatment Guidelines, 2010
Figure 5: Prostate Cancer Therapeutics Market, BRIC, Sales Value ($m), 2001–2009
Figure 6: Prostate Cancer Therapeutics Market, BRIC, Annual Cost of Therapy ($), 2001–2009
Figure 7: Prostate Cancer Therapeutics Market, BRIC, Patient Volume, 2001–2009
Figure 8: Prostate Cancer Therapeutics Market, BRIC, Treatment Usage Patterns, 2001–2009
Figure 9: Prostate Cancer Therapeutics Market, BRIC, Sales Value ($m), 2009–2020
Figure 10: Prostate Cancer Therapeutics Market, BRIC, Annual Cost of Therapy ($), 2009–2020
Figure 11: Prostate Cancer Therapeutics Market, BRIC, Patient Volume (absolute), 2009–2020
Figure 12: Prostate Cancer Therapeutics Market, BRIC, Treatment Usage Patterns, 2009–2020
Figure 13: Prostate Cancer Therapeutics Market, Brazil, Sales Value ($m), 2001-2009
Figure 14: Prostate Cancer Therapeutics Market, Brazil, Annual Cost of Therapy ($), 2001-2009
Figure 15: Prostate Cancer Therapeutics Market, Brazil, Patient Volume ('000s), 2001-2009
Figure 16: Prostate Cancer Therapeutics Market, Brazil, Treatment Usage Patterns ('000s), 2001-2009
Figure 17: Prostate Cancer Therapeutics Market, Brazil, Market Drivers and Restraints, 2009
Figure 18: Prostate Cancer Therapeutics Market, Brazil, Historical Events Impact on the Market, 2010
Figure 19: Prostate Cancer Therapeutics Market, Brazil, Sales Value ($m), 2009-2020
Figure 20: Prostate Cancer Therapeutics Market, Brazil, Annual Cost of Therapy ($), 2009-2020
Figure 21: Prostate Cancer Therapeutics Market, Brazil, Patient Volume ('000s), 2009-2020
Figure 22: Prostate Cancer Therapeutics Market, Brazil, Treatment Usage Patterns ('000s), 2009-2020
Figure 23: Prostate Cancer Therapeutics Market, Brazil, Future Events Expected to Impact the Market, 2010
Figure 24: Prostate Cancer, Russia, Sales Value ($m), 2001-2009
Figure 25: Prostate Cancer, Russia, Annual Cost of Therapy ($), 2001-2009
Figure 26: Prostate Cancer, Russia, Patient Volume (Thousands), 2001-2009
Figure 27: Prostate Cancer, Russia, Treatment Usage Patterns, 2001-2009
Figure 28: Prostate Cancer, Russia, Market Drivers and Restraints, 2009
Figure 29: Prostate Cancer, Russia, Historical Events Impact on the Market, 2010
Figure 30: Prostate Cancer, Russia , Sales Value ($m), 2009-2020
Figure 31: Prostate Cancer, Russia , Annual Cost of Therapy ($), 2009-2020
Figure 32: Prostate Cancer, Russia , Patient Volume (Thousands), 2009-2020
Figure 33: Prostate Cancer, Russia, Treatment Usage Patterns, 2009-2020
Figure 34: Prostate Cancer, Russia, Future Events Expected to Impact the Market, 2010
Figure 35: Prostate Cancer, India, Sales Value ($m), 2001-2009
Figure 36: Prostate Cancer, India, Annual Cost of Therapy ($), 2001-2009
Figure 37: Prostate Cancer, India, Patient Volume (Thousands), 2001-2009
Figure 38: Prostate Cancer, India, Treatment Usage Patterns, 2001-2009
Figure 39: Prostate Cancer, India, Market Drivers and Restraints, 2009
Figure 40: Prostate Cancer, India, Historical Events and Their Impact on the Market, 2010
Figure 41: Prostate Cancer, India, Sales Value ($m), 2009-2020
Figure 42: Prostate Cancer, India, Annual Cost of Therapy ($), 2009-2020
Figure 43: Prostate Cancer, India, Patient Volume (Thousands), 2009-2020
Figure 44: Prostate Cancer, India, Treatment Usage Patterns, 2009-2020
Figure 45: Prostate Cancer, India, Future Events Expected to Affect the Market, 2010
Figure 46: Prostate Cancer, China, Sales Value ($m), 2001-2009
Figure 47: Prostate Cancer, China, Annual Cost of Therapy ($), 2001-2009
Figure 48: Prostate Cancer, China, Patient Volume (Thousands), 2001-2009
Figure 49: Prostate Cancer, China, Treatment Usage Patterns, 2001-2009
Figure 50: Prostate Cancer, China, Market Drivers and Restraints, 2009
Figure 51: Prostate Cancer, China, Historical Events and Their Impact on the Market, 2010
Figure 52: Prostate Cancer, China, Sales Value ($m), 2009-2020
Figure 53 Prostate Cancer, China, Annual Cost of Therapy ($), 2009-2020
Figure 54: Prostate Cancer, China, Patient Volume (Thousands), 2009-2020
Figure 55: Prostate Cancer, China, Treatment Usage Patterns, 2009-2020
Figure 56: Prostate Cancer, China, Future Events Expected to Impact the Market, 2010
Figure 57: Prostate Cancer, Global, Strategic Competitor Assessment of Major Marketed Drugs, Chemotherapy Drugs, 2010
Figure 58: Prostate Cancer, Global, Strategic Competitor Assessment of Major Marketed Drugs, Hormone Therapy Drugs, 2010
Figure 59: Prostate Cancer, Global, Taxotere, Chemical Structure
Figure 60: Prostate Cancer, Global, Taxotere, LCM Activities, 2004-2010
Figure 61: Prostate Cancer, Global, Casodex, Chemical Structure
Figure 62: Prostate Cancer, Global, Casodex, LCM Activities, 2004-2010
Figure 63: Prostate Cancer, Global, Zoladex, Chemical Structure
Figure 64: Prostate Cancer, Global, Eligard , Chemical Structure
Figure 65: Prostate Cancer, Global, Lupron, Chemical Structure
Figure 66: Prostate Cancer, Global, Firmagon, Chemical Structure
Figure 67: Prostate Cancer, Global, Novatrone, Chemical Structure
Figure 68: Prostate Cancer, Global, Emcyt, Chemical Structure
Figure 69: Prostate Cancer, Global, Trelstar, Chemical Structure
Figure 70: Prostate Cancer, Global, Eulexin, Chemical Structure
Figure 71: Prostate Cancer, Global, Delestrogen, Chemical Structure
Figure 72: Prostate Cancer, Global, Gynodiol, Chemical Structure
Figure 73: Prostate Cancer, Global, Estrace, Chemical Structure
Figure 74: Prostate Cancer, Global, Tace, Chemical Structure
Figure 75: Prostate Cancer, Global, Nilandrone, Chemical Structure
Figure 76: Prostate Cancer, Global, Premarin, Chemical Structure
Figure 77: Prostate Cancer, Global, Clinical Trials by Therapy, 2010
Figure 78: Prostate Cancer, Global, Clinical Trials by Phase of Development, 2010
Figure 79: Prostate Cancer, Global, Pipeline by Mechanism of Action, 2010
Figure 80: Prostate Cancer, Global, Technology Trends Analytic Framework of Pipeline Drugs, 2010
Figure 81: Prostate Cancer, Global, Technology Trends Description of Pipeline Drugs, 2010
Figure 82: Prostate Cancer, Global, Licensing Agreements by Phase of Development, 2009-2010
Figure 83: Prostate Cancer, Global, Licensing Agreements by Geography, 2010
Figure 84: Prostate Cancer, Global, Aflibercept, Chemical Structure
Figure 85: Prostate Cancer, Global, Abiraterone, Chemical Structure
Figure 86: Prostate Cancer, Global, Zibotentan, Chemical Structure
Figure 87: Prostate Cancer, Global, MDV3100, Chemical Structure
Figure 88: Prostate Cancer, Global, Median Overall Survival for Hormone-independent Metastatic Prostate Cancer Patients, 2010
Figure 89: Prostate Cancer, Global, Median Overall Survival for Hormone-dependent Metastatic Prostate Cancer Patients, 2010
Figure 90: Prostate Cancer, Global, Hormone-dependent Metastatic Prostate Cancer Patients Achieving Castrate Level Testosterone Level in 28-30 Days (%), 2010
Figure 91: Prostate Cancer, BRIC, Prostate Cancer, Opportunity and Unmet Need, 2010
Figure 92: Prostate Cancer, BRIC, Hormone-independent Metastatic Prostate Cancer, Opportunity and Unmet Need, 2010
Figure 93: Prostate Cancer, BRIC, Hormone-dependent Metastatic Prostate Cancer, Opportunity and Unmet Need, 2010
Figure 94: Prostate Cancer, Global, Key Events Impacting the Future Market
Figure 95: Prostate Cancer, BRIC, Implications for Future Market Competition, 2010
Figure 96: Prostate Cancer, Global, Future Players in the Market, 2010
Figure 97:Prostate Cancer, Sanofi-aventis, Major Pharmaceutical Drugs 2010
Figure 98: Prostate Cancer, Sanofi-aventis Pasteur, Diseases Under Each Vaccination Area 2010
Figure 99: Prostate Cancer