Table Of Contents
CHAPTER ONE: EXECUTIVE SUMMARY
The Global Vaccine Industry
Scope and Methodology
Overview
Pediatric Preventative Vaccines
The Market
Adult Preventative Vaccines
The Market
Total Market
Issues and Trends
CHAPTER TWO: INTRODUCTION TO VACCINES
A Brief History: The Development of Vaccines
The Immune Response
Mechanism of Action
Types of Vaccines
Attenuated (Weakened) Live Viruses
Killed (Inactivated) Viruses
Toxoid Vaccines
Genetically Engineered/Modified Vaccines
Subunit Vaccines
Conjugate Vaccines
DNA Vaccination
Vaccine Approval Process
CHAPTER THREE: PEDIATRIC PREVENTIVE VACCINES
Introduction
Childhood Immunization in the United States
Childhood Immunization Rates
Challenges to the Vaccine Delivery System
The Effect of U.S. Health Care Reform
Recommended Childhood Immunization Schedule
State Immunization Recommendations
United Nations Initiatives
Pediatric Vaccine Products
BCG
Diphtheria, Tetanus, Pertussis, Hepatitis B and Polio
Diphtheria
Pertussis
Tetanus
Hepatitis B
Poliomyelitis
Haemophilus Influenzae Type B
Hepatitis A
Measles, Mumps and Rubella
Measles
Mumps
Rubella
Meningococcal Disease
Pneumococcal Conjugate
Rotavirus
Varicella
Pediatric Vaccines in Development
Cost of Vaccines in the United States The World Market for Pediatric Preventive Vaccines
Total Market Size and Forecast
Hepatitis Vaccine Market
Market Analysis
Leading Products and Competitors
Haemophilus Influenzae Type B Vaccine Market
Market Analysis
Leading Products and Competitors
Measles, Mumps and Rubella Vaccines
Market Analysis
Combination Vaccines Market
Market Analysis
Leading Products and Competitors
Pneumococcal Vaccine
Leading Products and Competitors
Poliovirus Vaccine
Market Analysi
Leading Products and Competitors
Varicella Vaccine
Market Analysis
Leading Products and Competitors
Other Vaccines Market
Market Analysis
Leading Products and Competitors
CHAPTER FOUR: ADULT PREVENTIVE VACCINES
Introduction
Adult Vaccine-Preventable Diseases: Facts and Figures
Global Influenza Surveillance Program
Recommendations for Adult Immunizations
WHO International Health Regulations
Adult Vaccine Products
BCG
Cervical Cancer
Cholera
Diphtheria-Tetanus
Hepatitis
Hepatitis A
Hepatitis B
Influenza
Japanese Encephalitis
Pneumococcal Disease
Rabies
Shingles
Typhoid Fever
Yellow Fever
Adult Vaccines in Development
Total Market Size and Forecast
Cervical Cancer Market
Market Analysis
Leading Products and Competitors
Hepatitis Market
Market Analysis
Leading Products and Competitors
Influenza Vaccine Market
Market Analysis
Leading Products and Competitors
Market Analysis
Leading Products and Competitors
Travel, DT, and Miscellaneous Vaccine Market
Market Analysis
Leading Products and Competitors
CHAPTER FIVE: VACCINES MARKET SUMMARY
Trends Driving the Vaccines Market
Market Size and Forecast
Vaccine Sales by Region
Vaccine Market Competitors
Pediatric Vaccines
Major Manufacturer’s Market Share
Adult Vaccines
Major Manufacturer’s Market Share
CHAPTER SIX: ISSUES AND TRENDS
Vaccine Safety
Refusal to Immunize
Obesity
Post-Licensure Surveillance
Vaccine Adverse Event Reporting System
The Vaccine Safety Datalink Project
Phase IV studies
The Vaccine Injury Compensation Program
Countermeasures Injury Compensation Program
World Health Organization
Other Initiatives
The Future of Vaccine Safety
Vaccine Shortages
Preventing Shortages in the Developed Countries
Financial incentives
Equitable pricing
Vaccine stockpiles
Preventing Shortages in Developing Nations
Vaccine bonds
Preventing Pandemics
U.S. National Vaccine Plan
Vaccines and Bioterrorism
Overview
Project Bioshield Act
National Bio and Agro-Defense Facility
Vaccine Treatment and Evaluation Units
Anthrax
Smallpox
Tularemia
Viral Hemorrhagic Fevers
DNA Vaccination
Innovations in Vaccine Delivery Systems
Edible Vaccines
Mucosal Delivery
Intranasal Delivery
Vaccine Patches
Vaccine Chips
Innovations in Vaccine Production
Tobacco Plants
Insects
Nanoparticle Systems
CHAPTER SEVEN: COMPANY PROFILES
AlphaVax, Inc.
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Bavarian Nordic A/S
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Baxter Healthcare
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Bharat Biotech
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Celldex Therapeutics
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Crucell
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Emergent Biosolutions
History and Lines of Business
Strategic Acquisition and Alliance
Vaccine Products
Financial
GlaxoSmithKline
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Medimmune
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Merck & Co. Inc
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Nabi Biopharmaceuticals
History and Lines of Business
Strategic Alliance
Vaccine Products
Financial Information
Novartis
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Pfizer
History and Lines of Business
Strategic alliances
Vaccine Products
Financial Information
Sanofi Pasteur
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
APPENDIX: COMPANY DIRECTORY
LIST OF EXHIBITS
CHAPTER ONE: EXECUTIVE SUMMARY
Figure 1-1: World Market for Pediatric Vaccines 2005-2014 Revenues (in millions)
Figure 1-2: World Market for Adult Vaccines 2005-2014 Revenues (in millions)
CHAPTER TWO: INTRODUCTION TO VACCINES
Table 2-1: Impact of Vaccines in the 20th Century Annual Morbidity in the 20th Century vs 2009
Table 2-2: Vaccine-Preventable Diseases, June 2010
Table 2-3: VAERS Table of Reportable Events Following Vaccination
CHAPTER THREE PEDIATRIC PREVENTIVE VACCINES
Table 3-1: Global Immunization Rates by Vaccine Type 2008
Table 3-2: Immunization Profile of the United States: Population by Age Group, Number of Vaccine-Preventable Diseases Reported by Disease 2002-2008
Table 3-3 : U.S. Recommended Immunization Schedule for Children Ages 0 Through 6 Years, 2010
Table 3-4: U.S. Recommended Immunization Schedule for Adolescents Ages 7 to 18 Years, 2010
Table 3-5: Selected Pediatric Vaccines in Development, June 2010
Table 3-6 : World Market for Pediatric Vaccines by Type (DTaP/DTP, Hep, HiB, MMR, Combinations, Pneumococcal, Polio, Varicella, Others) 2005-2014 Revenues (in millions)
Figure 3-1: Market Share of Pediatric Vaccines by Type 2009
Figure 3-2: Market Share of Pediatric Vaccines, by Type 2014
Table 3-7 : World Market for Pediatric Vaccines by Region (U.S., North America, South America, EU, Japan, India, China, Rest of World) 2005-2014 Revenues (in millions)
Table 3-8: World Pediatric Hepatitis Vaccine Market 2005-2014 World Hib Vaccine Market, 2005-2014
Table 3-10: World MMR Vaccines Market 2005-2014
Table 3-11 World Combination Vaccines Market 2005-2014
Table 3-12 World Pediatric Pneumococcal Vaccine Market 2005-2014
Table 3-13 World Poliovirus Vaccine Market 2005-2014
Table 3-14 World Varicella Vaccine Market 2005-2014
Table 3-15 World Pediatric Other Vaccines Market 2005-2014
CHAPTER FOUR ADULT PREVENTIVE VACCINES
Table 4-1 Universal Adult Immunization Schedule 2010
Table 4-2 Adult Immunization Schedule for Populations with Special Medical Conditions, 2010
Table 4-3 Initiatives to Require HPV Vaccination by U.S. State, 2010
Table 4-4 WHO Pandemic Classification Schedule Selected Adult Preventive Vaccines in Development, 2010
Table 4-6 World Market for Adult Preventive Vaccines by Type (Hepatitis, Influenza, Pneumococcal, Travel/DT/Misc.), 2005-2014 Revenues (in millions)
Figure 4-1 Market Share of Adult Vaccines, by Type, 2009
Figure 4-2 Market Share of Adult Vaccines, by Type, 2014
Table 4-7 World Market for Adult Vaccines by Region (U.S., North America, South America, EU, Japan, India, China, Rest of World) 2005-2014 Revenues (in millions)
Table 4-8 World Cervical CancerVaccine Market 2005-2014
Table 4-9 World Hepatitis Vaccine Market 2005-2014 World Influenza Vaccine Market 2005-2014
Table 4-11 CDC Goal to Double Flu Immunization by 2010 Group and Estimated Immunization Rate (2000 vs 2010)
Table 4-12 2009 Estimated Population by Region and Selected Age Group (in millions)
Table 4-13 World Pneumococcal Vaccine Market 2005-2014 World Travel; Diphtheria-Tetanus; Miscellaneous Vaccines Market 2005-2014 160
CHAPTER FIVE VACCINES MARKET SUMMARY
Figure 5-1 Sales Growth of Vaccines vs. Pharmaceuticals 2005-2014
Figure 5-2 World Market for Vaccines by Type 2005-2014
Table 5-1 The World Vaccines Market by Vaccine Type 2005-2014 Revenues (in millions
Figure 5-3 World Market for Vaccines Share by Type, 2005, 2009 and 2014
Table 5-2 The World Vaccines Market by Region 2005-2014 Revenues (in millions)
Table 5-3 Major Manufacturers’ Shares of the World Vaccine Market, 2009
Figure 5-3 2009 World Vaccines Market Share, by Leading Competitors
Table 5-4 Major Manufacturer’s Shares of the World Pediatric Vaccine Market 2009
Figure 5-5 Market Share of Pediatric Vaccines Market, 2009
Table 5-5 Major Manufacturer’s Shares of the World Adult Vaccine Market 2009
Figure 5-6: Market Share of Adult Vaccines Market 2009
CHAPTER SIX ISSUES AND TRENDS
Table 6-1: Selected Companies/Laboratories Developing Biodefense Vaccines
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