Therapeutic Class Overview: Newer Oral Anti Androgens – Expanding Role in the treatment Paradigm of Prostate Cancer

Published: February 2014
No. of Pages: 44
    ReportsandReports

XTANDI (Enzalutamide) – Does it have potential to compete against ARN-509 in earlier setting?

Zytiga (Abiraterone Acetate) – Ongoing Combination trials creates potential beyond Patent Expiry

In recent past approval and launch of various newer treatment options like Xtandi (Enzalutamide, Astellas/Medivation), Zytiga (Abiraterone acetate, JNJ), Jevtana (Cabazitaxel, Sanofi), & Xofigo (radium Ra 223, Boehringer Ingelheim) has evolved the treatment paradigm of treating late stage prostate cancer. In coming years, we expect this to repeat in early stage prostate cancer treatment (nmCRPC, before Prostectomy) due to launch of newer antiandrogens in this setting.  Longer duration of therapy and high prevalence makes this earlier setting market more lucrative and bigger for newer options than late stage if they succeed.

In coming years, we expect second generation antiandrogens (Androgen synthesis inhibitors/Androgen receptor inhibitors, Xtandi, ARN-509, ODM-021, Zytiga, TAK-700, TOK-001) to replace them and expand their use beyond current levels in nmCRPC (non metastatic Castrate resistance Prostate cancer) patients and also in pre-prostectomy (Chart 3).  This newer agents will expand these markets atleast by $10b ($6b in pre prostectomy, $4b nmCRPC) if get success.

TAK-700 (Takeda), ARN-509 (JNJ) and Xtandi are strong candidates to get success in early stage prostate cancer and in next two years PhIII clinical data from EL-04, PROSPER and SPARTAN study, will decide who will lead this market.  While TAK-700 has a first launch advantage it is important to see how ARN-509, compete to Xtandi in earlier setting and in terms of safety for penetrating in early prostate cancer market.  Other than these PhIII studies, Xtandi PhII data from neoadjuvant PC and ARN-509 data in preprostectomy patients will decide their use in earlier setting. We estimate $2.8b peak sales for Xtandi in mCRPC setting, while in earlier setting it has potential to generate atleast ~$2b if it gets success in PROSPER , STRIVE, TERRAIN and neoadjuvant study.

Published By: MP Advisors
Product Code: MP Advisors21


Did you find what you are/were looking for ? If not, read below and browse through other relevant pages for similar market research reports OR get in touch with us through the form/contact info in your right navigation panel and well share relevant market report titles for you to explore.

Related Reports:

  • United States Bark Fines Market Report 2017

    Notes: Sales, means the sales volume of Bark Fines Revenue, means the sales value of Bark Fines This report studies sales (consumption) of Bark Fines in United States market, focuses on the top players, with sales, price, revenue and market shar...

  • United States Remote Health Delivery Market Report 2017

    Notes: Sales, means the sales volume of Remote Health Delivery Revenue, means the sales value of Remote Health Delivery This report studies sales (consumption) of Remote Health Delivery in United States market, focuses on the top players, with s...

  • United States Calcium Alginate Dressing Market Report 2017

    Notes: Sales, means the sales volume of Calcium Alginate Dressing Revenue, means the sales value of Calcium Alginate Dressing This report studies sales (consumption) of Calcium Alginate Dressing in United States market, focuses on the top player...

  • United States Biologics Market Report 2017

    Notes: Sales, means the sales volume of Biologics Revenue, means the sales value of Biologics This report studies sales (consumption) of Biologics in United States market, focuses on the top players, with sales, price, revenue and market share f...

  • United States Aspartame Free Proteins Market Report 2017

    Notes: Sales, means the sales volume of Aspartame Free Proteins Revenue, means the sales value of Aspartame Free Proteins This report studies sales (consumption) of Aspartame Free Proteins in United States market, focuses on the top players, wit...

  • United States Hybrid-Ceramic Dental CAD/CAM Material Market Report 2017

    Notes: Sales, means the sales volume of Hybrid-Ceramic Dental CAD/CAM Material Revenue, means the sales value of Hybrid-Ceramic Dental CAD/CAM Material This report studies sales (consumption) of Hybrid-Ceramic Dental CAD/CAM Material in United S...

  • United States Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2017

    Notes: Sales, means the sales volume of Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Revenue, means the sales value of Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) This report studies sales (consumption) of Circulat...

  • United States Opioids Drugs Market Report 2017

    Notes: Sales, means the sales volume of Opioids Drugs Revenue, means the sales value of Opioids Drugs This report studies sales (consumption) of Opioids Drugs in United States market, focuses on the top players, with sales, price, revenue and ma...

  • United States Naloxone Market Report 2017

    Notes: Sales, means the sales volume of Naloxone Revenue, means the sales value of Naloxone This report studies sales (consumption) of Naloxone in United States market, focuses on the top players, with sales, price, revenue and market share for ...

  • United States Biosimilars Market Report 2017

    Notes: Sales, means the sales volume of Biosimilars Revenue, means the sales value of Biosimilars This report studies sales (consumption) of Biosimilars in United States market, focuses on the top players, with sales, price, revenue and market s...


Why ReportsnReports.com?

  • 500,000 market research reports and growing.
  • Top Fortune 500 Organizations trust us for research data.
  • 24/7 support on call as well as emails.
  • Your Details are safe with us.
  • Free support for your research requirements.
  • Report Delivery: Email
  • Delivery Time:
    • Upto 24 hrs - working days
    • Upto 48 hrs max - weekends and public holidays

Research Support / Custom Research

If this business study does not have the data and information analysis you need, contact us with your research requirements. We explore available market research reports to map your needs and share report titles with you. Alternatively, we can also offer custom research that suits your budget and timelines. Share your information requirements here.
Connect With Us
Email: sales@reportsandreports.com Call : + 1 888 391 5441

Subscription Option

Using our subscription option, you get access to market research reports and industry data of Consumer Goods market as per your needs. Get the best of Consumer Goods research reports by utilizing your research budgets in an optimum way.

More about our Subscription option
Report Alerts

Get Email alerts about market research reports from industries and publishers of your interest: