Table of Contents
I. Introduction
II. Worldwide Technology and Market Overview
A. Major Blood Typing, Grouping and Infectious Disease Screening Tests
1. Blood Typing and Grouping Tests
a. ABO
b. Antibody Panels
c. Antibody Screening
d. Antigen Typing
e. Antiglobulin Test
f. Crossmatch
g. HLA Typing
h. Rh
i. Other Blood Groups
2. Infectious Disease Screening Tests
a. AIDS
Structure and Composition
Classification
Origin of AIDS
Animal Lentivirus Systems
Virus Receptors
HIV Infections in Humans
Pathogenesis & Pathology
Overview of Course of HIV Infection
CD4T Lymphocytes and Memory Cells
Monocytes and Macrophages
Lymphoid Organs
Neural Cells
Viral Coinfections
Clinical Findings
Plasma Viral Load
Pediactric AIDS
Neurologic Disease
Opportunistic Infections
Protozoa
Fungi
Bacteria
Viruses
Cancer
Immunity
Laboratory Diagnosis
Virus Isolation
Serology
Detection of Viral Nucleic Acid or Antigens
Epidemiology
Worldwide Spread of AIDS
United States
Routes of Transmission
Prevention, Treatment, And Control
Antiviral Drugs
Vaccines Against HIV
Transmission of HIV in Blood Products
HIV Transmission in Transplant and
Artificial Insemination Recipients
Diagnostic Tests
Enzyme Immunoassay Interpretation
Specificity, Sensitivity, and Predictive
Value of Enzyme Immunoassay
Competition Assays
Western Blot Technique
ImmunoFluorescence Assay (IFA)
Radioimmunoprecipitation
HIV1/HIV2 Combination Testing
Methods of HIVAntigen Detection
Antigen Assays and Blood Screening
Urine Tests
DNA Probes
Overview
Quantitative Polymerase Chain Reaction
In Situ PCR
Needed Improvements
Viral Load/Drug Resistance Testing
Genotype and Phenotype Testing
Blood Banking Considerations
b. Hepatitis
Hepatitis A
Hepatitis B
Structure and Composition
Replication of Hepatitis B Virus
Hepatitis C
Hepatitis D (Delta Hepatitis)
Hepatitis E
Hepatitis G
Hepatitis Virus Infections In Humans
Pathology
Clinical Findings
Laboratory Features
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D
Hepatitis E
VirusHost Immune Reactions
Epidemiology
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D (Delta Agent)
Vaccines and Drugs
c. Cytomegalovirus
Background
Chorioretinitis
Gastrointestinal
Central Nervous System Disease
Diagnostic Tests
Vaccines and Drugs
d. Syphilis
Background
Diagnostic Tests
Vaccines and Drugs
e. West Nile Virus
Background
Clinical Syndromes
Diagnostic Tests
Vaccines and Drugs
f. Parvovirus B19
Microbiology
Epidemiology
Clinical Syndromes
Erythema Infectiosum Slapped (cheek)
Adult Polyarthropathy
Transient Aplastic Crisis
Transient Pancytopenia
Red Cell Aplasia in the Immunocompromised
Perinatal Infections
Diagnosis
Treatment
g. CreutzfeldtJakob’s Disease
Background
Transmission
Diagnostic Tests
Major Commercial and Academic Players
Bayer
Disease Sciences/BioTec Global
Imperial College School of Medicine
OrthoClinical Diagnostics
Pall
ProMetic Life Sciences
Proteome Sciences/Idexx
QOne Biotech
Serono
U.S. Agricultural Research Service
Drugs
Vaccines
h. Malaria
i. Chagas Disease
j. Babesiosis
3. Pathogen Reduction
4. Leukocyte Reduction
Background
Methods
B. Instrumentation Review
Introduction
1. Abbott Architect i2000 Series
2. Abbott AxSYM
3. Abbott LCx
4. Abbott Prism
5. Abbott Quantum II
6. Beckman Coulter/Biomek FX
7. Beckman Coulter BloodTrack Courier
8. Beckman Coulter OLA2500
9. Beckman Coulter PK7100
10. Beckman Coulter PK7200
11. Beckman Coulter PK80
12. Beckman Coulter Tango
13. BioRad Elite
14. BioRad GeneScope
15. BioMerieux Bac/Alert
16. GenProbe Tigris
17. Grifols Diana
18. Immucor ABS2000
19. Immucor Galileo
20. Immucor Rosys Plato System
21. Nanosphere Verigen Series
22. Ortho AutoVue/ProVue
23. Ortho StarFame Combo
24. Ortho Summit Processor
25. Roche Cobas Amplicor
26. Roches Cobas s 201
27. Sarstedt PVS
28. Siemens BEP 2000
29. Siemens Quadriga
30. Siemens SDA
31. Tecan ELPHAtyper
32. Tecan Genesis FE500
33. Tecan Hemotyper
34. Tecan LS Series
35. Tecan MegaFlex
36. Tecan MiniSwift
C. Major in Vitro Diagnostic Technologies And Their Potential Applications
1. Molecular Diagnostics
a. Overview
b. NAT
2. Monoclonal and Polyclonal Antibodies
3. Immunoassays
a. Technological Principle
b. Enzyme Immunoassays (EIA)
Overview
ELISA
Enzyme Amplification
c. Fluorescent Immunoassays
Fluorescence Polarization
d. Luminescence
Chemiluminescence
Bioluminescence
e. Latex Agglutination
f. Immunoprecipitation
4. Microtitration Plates
5. Information Technology
6. Automation
7. Lasers
8. Robotics
9. Artificial Intelligence
10. Synthetic Red Cell Substitutes
11. Genetically Engineered Blood Components
a. Albumin
b. Factor VIII
c. Alpha2 Antiplasmin
d. Antithrombin III
e. Factor IX
f. Von Willebrand's Factor
g. Fibrinogen
h. tPA
12. Blood Preservation
13. Autologous Blood Transfusion/Freezing
France
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth and Major Suppliers’
Consumable Sales, Instrument Placements,
Installed Base and Market Shares
Germany
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth and Major Suppliers’
Consumable Sales, Instrument Placements,
Installed Base and Market Shares
Italy
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth and Major Suppliers’
Consumable Sales, Instrument Placements,
Installed Base and Market Shares
Spain
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth and Major Suppliers’
Consumable Sales, Instrument Placements,
Installed Base and Market Shares
U.K.
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth and Major Suppliers’
Consumable Sales, Instrument Placements,
Installed Base and Market Shares
Major Product Development Opportunities
A. Blood Typing and Grouping
B. Infectious Disease Screening
C. Auxiliary
Alternative Market Penetration Strategies
A. Internal Development
B. Collaborative Arrangements
C. University Contracts
Potential Market Entry Barriers and Risks
A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge and Limitations
E. Patent Protection
Competitive Assessments
Abbott
Beckman Coulter
Becton Dickinson
Biokit
BioMerieux
BioRad
Diagast
DiaSorin
Fujirebio
GenProbe
Grifols
Immucor
Innogenetics
OrthoClinical Diagnostics
Orchid CellMark
Novartis Diagnostics
Proteome Sciences
Roche
Siemens
Tecan
Appendix: Assumed Currency Exchange Rates
List of Tables
Major Companies Developing or Marketing
Blood Typing and Grouping Tests
Major Companies Developing or Marketing
HLA Typing Tests
Major Companies Developing or Marketing
AIDS Tests
Major Companies Developing or Marketing
Hepatitis Tests
Major Companies Developing or Marketing
CMV Tests
Major Companies Developing or Marketing
Syphilis Tests
Major Companies Developing or Marketing
Blood Bank Analyzers
Executive Summary Table: France, Total Blood Bank
Test Volume and Reagent Sales Forecast
By Test Category
France, Facilities Performing Blood
Bank Tests by Market Segment
France, Hospital Laboratories Performing
Blood Bank Tests by Bed Size
France, Commercial/Private Laboratories
Performing Blood Bank Tests By Annual Test Volume
France, All Market Segments Blood Typing
And Grouping Test Volume Forecast
y Market Segment
France, All Market Segments Blood Typing
And Grouping Test Volume Forecast
France, Hospital Laboratories Blood
Typing and Grouping Test Volume Forecast
France, Blood Banks Blood Typing
And Grouping Test Volume Forecast
France, Commercial/Private Laboratories
Blood Typing and Grouping Test Volume Forecast
France, All Market Segments Infectious
Disease Screening Test Volume Forecast
By Market Segment
France, All Market Segments Infectious
Disease Screening Test Volume Forecast
France, Blood Banks Infectious Disease
Screening Test Volume Forecast
France, Commercial/Private Laboratories
Infectious Disease Screening Test Volume Forecast
France, Hospital Laboratories Infectious
Disease Screening Test Volume Forecast
France, All Market Segments Blood Typing
And Grouping Reagent Market Forecast
By Market Segment
France, All Market Segments Blood Typing
And Grouping Reagent Market Forecast
By Major Test
France, Hospital Laboratories Blood
Typing and Grouping Reagent Market Forecast
By Major
France, Blood Banks Blood Typing
and Grouping Reagent Market Forecast
by Major Test
France, Commercial/Private Laboratories
Blood Typing and Grouping Reagent Market
Forecast By Major Test
France, All Market Segments Infectious
Disease Screening Reagent Market Forecast
By Market Segment
France, All Market Segments Infectious
Disease Screening Reagent Market Forecast
By Test
France, Blood Banks Infectious Disease
Screening Reagent Market Forecast by Test
France, Commercial/Private Laboratories
Infectious Disease Screening Reagent Market Forecast
By Test
France, Hospital Laboratories Infectious
Disease Screening Reagent Market Forecast by Test
France, Major Suppliers of Blood Typing
And Grouping Reagents Estimated Sales
And Market Shares
France, HIV/HTLV Blood Screening Market,
Reagent Sales by Major Supplier
France, Hepatitis Blood Screening Market,
Reagent Sales by Major Supplier
France, HIV/Hepatitis NAT Screening Market
Reagent Sales by Major Supplier
France, CMV Blood Screening Market,
Reagent Sales By Major Supplier
France, Syphilis Blood Screening Market,
Reagent Sales By Major Supplier
France, Major Suppliers of Blood Bank
Automated Analyzers, Estimated Placements
and Installed Base By Supplier and Model
Executive Summary Table: Germany, Total Blood Bank
Test Volume and Reagent Sales Forecast
by Test Category
Germany, Facilities Performing Blood
Bank Tests by Market Segment
Germany, Hospital Laboratories Performing
Blood Bank Tests by Bed Size
Germany, Commercial/Private Laboratories
Performing Blood Bank Tests by Annual
Test Volume
Germany, All Market Segments Blood Typing
And Grouping Test Volume Forecast
by Market Segment
Germany, All Market Segments Blood Typing
And Grouping Test Volume Forecast
Germany, Hospital Laboratories Blood
Typing and Grouping Test Volume Forecast
Germany, Blood Banks Blood Typing
And Grouping Test Volume Forecast
Germany, Commercial/Private Laboratories
Blood Typing and Grouping Test Volume Forecast
Germany, All Market Segments Infectious
Disease Screening Test Volume Forecast
By Market Segment
Germany, All Market Segments Infectious
Disease Screening Test Volume Forecast
Germany, Blood Banks Infectious Disease
Screening Test Volume Forecast
Germany, Commercial/Private Laboratories
Infectious Disease Screening Test Volume Forecast
Germany, Hospital Laboratories Infectious
Disease Screening Test Volume Forecast
Germany, All Market Segments Blood Typing
And Grouping Reagent Market Forecast
by Market Segment
Germany, All Market Segments Blood Typing
And Grouping Reagent Market Forecast
By Major Test
Germany, Hospital Laboratories Blood
Typing and Grouping Reagent Market Forecast
By Major Test
Germany, Blood Banks Blood Typing and
Grouping Reagent Market By Major Test Forecast
Germany, Commercial/Private Laboratories
Blood Typing and Grouping Reagent Market
Forecast By Major Test
Germany, All Market Segments Infectious
Disease Screening Reagent Market Forecast
By Market Segment
Germany, All Market Segments Infectious
Disease Screening Reagent Market Forecast by Test
Germany, Blood Banks Infectious Disease
Screening Reagent Market Forecast by Test
Germany, Commercial/Private Laboratories
Infectious Disease Screening Reagent Market
Forecast By Test
Germany, Hospital Laboratories Infectious
Disease Screening Reagent Market Forecast by Test
Germany, Major Suppliers of Blood Typing
And Grouping Reagents Estimated Sales
And Market Shares
Germany, HIV1/2 Blood Screening Market,
Reagent Sales by Major Supplier
Germany, Hepatitis Blood Screening Market,
Reagent Sales by Major Supplier
Germany, HIV/Hepatitis NAT Market,
Reagent Sales by Major Supplier
Germany, CMV Blood Screening Market,
Reagent Sales by Major Supplier
Executive Summary Table: Italy, Total Blood Bank
Test Volume and Reagent Sales Forecast
by Test Category
Italy, Facilities Performing Blood
Bank Tests by Market Segment
Italy, Hospital Laboratories Performing
Blood Bank Tests by Bed Size
Italy, Commercial/Private Laboratories
Performing Blood Bank Tests
by Annual Test Volume
Italy, All Market Segments Blood Typing
And Grouping Test Volume by Market Segment
Italy, All Market Segments Blood Typing
And Grouping Test Volume Forecast
Italy, Hospital Laboratories Blood
Typing and Grouping Test Volume Forecast
Italy, Blood Banks Blood Typing
And Grouping Test Volume Forecast
Italy, Commercial/Private Laboratories
Blood Typing and Grouping Test Volume Forecast
Italy, All Market Segments Infectious
Disease Screening Test Volume Forecast
by Market Segment
Italy, All Market Segments Infectious
Disease Screening Test Volume Forecast
Italy, Blood Banks Infectious Disease
Screening Test Volume Forecast
Italy, Commercial/Private Laboratories
Infectious Disease Screening Test Volume Forecast
Italy, Hospital Laboratories Infectious
Disease Screening Test Volume Forecast
Italy, All Market Segments Blood Typing
and Grouping Reagent Market Forecast
by Market Segment
Italy, All Market Segments Blood Typing
And Grouping Reagent Market Forecast
by Major Test
Italy, Hospital Laboratories Blood
Typing and Grouping Reagent Market Forecast
By Major Test
Italy, Blood Banks Blood Typing
and Grouping Reagent Market Forecast
by Major Test
Italy, Commercial/Private Laboratories
Blood Typing and Grouping Reagent Market Forecast
By Major Test
Italy, All Market Segments Infectious
Disease Screening Reagent Market Forecast
by Market Segment
Italy, All Market Segments Infectious
Disease Screening Reagent Market Forecast by Test
Italy, Blood Banks Infectious Disease
Screening Reagent Market Forecast by Test
Italy, Commercial/Private Laboratories Infectious
Disease Screening Reagent Market Forecast by Test
Italy, Hospital Laboratories
Infectious Disease Screening Reagent Market Forecast
By Test
Italy, Major Suppliers of Blood Typing
And Grouping Reagents Estimated Sales
And Market Shares
Italy, AIDS/Hepatitis Blood Screening Market,
Reagent Sales by Major Supplier
Italy, HIV/Hepatitis NAT Market,
Reagent Sales by Major Supplier
Italy, CMV Blood Screening Market,
Reagent Sales By Major Supplier
Executive Summary Table: Spain, Total Blood Bank
Test Volume and Reagent Sales Forecast
by Test Category
Spain, Facilities Performing Blood
Bank Tests by Market Segment
Spain, Hospital Laboratories Performing
Blood Bank Tests by Bed Size
Spain, Commercial/Private Laboratories
Performing Blood Bank Tests
by Annual Test Volume
Spain, All Market Segments Blood Typing
And Grouping Test Volume Forecast
by Market Segment
Spain, All Market Segments Blood Typing
and Grouping Test Volume Forecast
Spain, Hospital Laboratories Blood
Typing and Grouping Test Volume Forecast
Spain, Blood Banks Blood Typing
And Grouping Test Volume Forecast
Spain, Commercial/Private Laboratories
Blood Typing and Grouping Test Volume Forecast
Spain, All Market Segments Infectious
Disease Screening Test Volume Forecast
By Market Segment
Spain, All Market Segments Infectious
Disease Screening Test Volume Forecast
Spain, Blood Banks Infectious Disease
Screening Test Volume Forecast
Spain, Commercial/Private Laboratories
Infectious Disease Screening Test Volume Forecast
Spain, Hospital Laboratories Infectious
Disease Screening Test Volume Forecast
Spain, All Market Segments Blood Typing
And Grouping Reagent Market Forecast
By Market Segment
Spain, All Market Segments Blood Typing
And Grouping Reagent Market Forecast
by Major Test
Spain, Hospital Laboratories Blood
Typing and Grouping Reagent Market Forecast
By Major Test
Spain, Blood Banks Blood Typing
and Grouping Reagent Market
By Major Test Forecast
Spain, Commercial/Private Laboratories
Blood Typing and Grouping Reagent Market Forecast
By Major Test
Spain, All Market Segments Infectious
Disease Screening Reagent Market Forecast
by Market Segment
Spain, All Market Segments Infectious
Disease Screening Reagent Market Forecast by Test
Spain, Blood Banks Infectious Disease
Screening Reagent Market Forecast by Test
Spain, Commercial/Private Laboratories
Infectious Disease Screening Reagent Market
Forecast By Test
Spain, Hospital Laboratories Infectious
Disease Screening Reagent Market Forecast by Test
Spain, Major Suppliers of Blood Typing
And Grouping Reagents Estimated Sales
And Market Shares
Spain, HIV1/2 Blood Screening Market,
Reagent Sales by Major Supplier
Spain, Hepatitis Blood Screening Market,
Reagent Sales by Major Supplier
Spain, HIV/Hepatitis NAT Market,
Reagent Sales by Major Supplier
Spain, CMV Blood Screening Market,
Reagent Sales by Major Supplier
Spain, Syphilis Blood Screening Market,
Reagent Sales by Major Supplier
Executive Summary Table: U.K., Total Blood Bank
Test Volume and Reagent Sales Forecast
by Test Category
U.K., Facilities Performing Blood
Bank Tests by Market Segment
U.K., Hospital Laboratories Performing
Blood Bank Tests by Bed Size
U.K., Commercial/Private Laboratories
Performing Blood Bank Tests
by Annual Test Volume
U.K., All Market Segments Blood Typing
And Grouping Test Volume Forecast
by Market Segment
U.K., All Market Segments Blood Typing
And Grouping Test Volume Forecast
U.K., Hospital Laboratories Blood
Typing and Grouping Test Volume Forecast
U.K., Blood Banks Blood Typing
And Grouping Test Volume Forecast
U.K., Commercial/Private Laboratories
Blood Typing and Grouping Test Volume Forecast
U.K., All Market Segments Infectious
Disease Screening Test Volume Forecast
by Market Segment
U.K., All Market Segments Infectious
Disease Screening Test Volume Forecast
U.K., Blood Banks Infectious Disease
Screening Test Volume Forecast
U.K., Hospital Laboratories
Infectious Disease Screening Test Volume Forecast
U.K., Commercial/Private Laboratories Infectious
Disease Screening Test Volume Forecast
U.K., All Market Segments Blood Typing
And Grouping Reagent Market Forecast
By Market Segment
U.K., All Market Segments Blood Typing
And Grouping Reagent Market Forecast
by Major Test
U.K., Hospital Laboratories Blood
Typing and Grouping Reagent Market Forecast
By Major Test
U.K., Blood Banks Blood Typing
and Grouping Reagent Market Forecast
by Major Test
U.K., All Market Segments Infectious
Disease Screening Reagent Market Forecast
By Market Segment
U.K., All Market Segments Infectious
Disease Screening Reagent Market
Forecast Segment By Test
U.K., Blood Banks Infectious Disease
Screening Reagent Market Forecast by Test
U.K., Hospital Laboratories
Infectious Disease Screening Reagent Market
Forecast By Test
U.K., Commercial/Private Laboratories Infectious
Disease Screening Reagent Market Forecast by Test
U.K., Major Suppliers of Blood Typing
And Grouping Reagents Estimated Sales
And Market Shares
U.K., HIV1/2 Blood Screening Market,
Reagent Sales by Major Supplier
U.K., Hepatitis Blood Screening Market,
Reagent Sales by Major Supplier
U.K., Syphilis Blood Screening Market,
Reagent Sales by Major Supplier