Genomics, proteomics and metabolomics in diagnostics
Executive summary
Market overview
Biomarkers
Microarrays and microfluidics
Lab-on-a-chip proteomics
Bioinformatics
Emerging applications
Applications market
Competitive landscape
Patent analysis
Geographic analysis
Company profiles
Chapter 1 Market overview
Summary
Emerging trends focus on survival rates and non-invasive methods
Accuracy remains the key for next generation omics-based diagnostics
Biomarkers setting standards for ideal diagnostic methodology
Key market drivers & resistors
Chapter 2 Biomarkers
Summary
Defining biomarkers
The biomarker market
Market drivers
Restraints
Emerging applications of biomarkers
Omics technologies
Disease predisposition
Pre-natal testing
Biomarkers and translational medicine
Proteomics and biomarker applications
Post-genomic biomarker technologies
Innovative technologies provide patient centric data
Genomic technologies play a significant role in nutritional research
Molecular diagnostics
Mass spectrometry (MS)
Gel electrophoresis
Metabolomics
Imaging biomarkers
Confluence of diagnostics and pharmaceutical companies
Challenges
High investment hampers advance biomarker research
Validation challenge
Lack of IT solutions
Chapter 3 Microarrays and microfluidics
Summary
Microarrays and microfluidics
Market drivers
Market restraints
DNA microarrays
Fabrication technologies
Printing with fine-pointed pins onto glass slides
Photolithography using pre-made masks
Ink-jet printing
Analytical methods
mRNA profiling
Genetic imbalance detection
Gene expression profiling
SNP detection
DNA microarrays in in vitro diagnostics (IVD)
Protein microarrays
Protein immobilization strategies
Surface chemistries
Format of protein chips
Complete protein profiling utility
Tissue and cell microarrays
Chapter 4 Lab-on-a-chip proteomics
Summary
Introduction
Classification of LOCs
Market drivers for LOC
Drawbacks
Chapter 5 Bioinformatics
Summary
Introduction
Market drivers
Market restraints
Applications in diagnostics
Strategic recommendations
Advancements in molecular diagnostics and bioinformatics
Chapter 6 Emerging applications
Summary
Quantitative real-time polymerase chain reaction (qPCR)
DNA biosensors
Flow cytometry
DNA methylation
Nanotechnology
Other novel diagnostic applications
DNA testing technologies
Mass spectrometry and proteomics
H1N1
Metabolomics and related diagnosis
MicroRNA
Use of protein microarrays for early detection of disease
Next-generation sequencing technologies and IT technologies
Biomarkers
Chapter 7 Applications market
Summary
Application by utility
Sequence analysis
Structure analysis
Function analysis
Application by disease
Cancer
Infectious disease
HIV
Autoimmune diseases
Neurological disorders
Cardiovascular and metabolic disease
Chapter 8 Competitive landscape
Summary
Agreements and collaborations
New product/service launches
Mergers and acquisitions
Chapter 9 Patent analysis
Summary
Introduction
Patents by technology
Patents by geography
Patents by assignee
Chapter 10 Geographic analysis
Summary
Global diagnostics market
North America
Europe
Asia
Rest of the World (ROW)
Chapter 11 Company profiles
Summary
Affymetrix
Company overview
Products and services
Strategy and developments
Agilent Technologies
Company overview
Products and services
Strategy and developments
Amgen
Company overview
Products and services
Strategy and developments
Beckman Coulter
Company overview
Products and services
Strategy and developments
Bio-Rad Laboratories
Company overview
Product and services
Strategy and developments
BG Medicine
Company overview
Products and services
Strategy and developments
Biophysical Corp
Company overview
Products and services
Strategy and developments
BioSystems International (BSI)
Company overview
Products and services
Strategy and developments
Calibrant
Company overview
Products and services
Strategy and development
Caprion Proteomics
Company overview
Products and services
Strategy and developments
deCODE Genetics
Company overview
Products and services
Strategy and developments
Exagen Diagnostics
Company overview
Products and services
Strategy and developments
GE Healthcare
Company overview
Strategy and developments
Genedata
Company overview
Products and services
Strategy and developments
GeneNews
Company overview
Products and services
Strategy and developments
Human Metabolome Technologies (HMT)
Company overview
Products and services
Strategy and developments
Illumina, Inc.
Company overview
Products and services
Strategy and development
Imgenex
Company overview
Products and services
Strategy and developments
InforSense
Company overview
Products and services
Strategy and developments
Integromics
Company overview
Products and services
Strategy and developments
MDS, Inc.
Company overview
Products and services
Strategy and developments
Metabolon, Inc.
Company overview
Products and services
Strategy and developments
Metanomics Health GmbH
Company overview
Products and services
Strategy and developments
Microchip Biotechnologies
Company overview
Products and services
Strategy and developments
MicroDiscovery
Company overview
Products and services
Strategy and developments
Molecular Connections
Company overview
Products and services
Strategy and developments
NextGen Group PLC
Company overview
Products and services
Strategy and developments
Nonlinear USA, Inc.
Company overview
Products and services
Strategy and developments
Nuvera Biosciences
Company overview
Products and services
Strategy and developments
Ocimum Biosolutions
Company overview
Products and services
Strategy and developments
Pam Gene BV
Company overview
Products and services
Strategy and developments
Siemens Healthcare
Company overview
Products and services
Strategy and developments
Chapter 12 Appendix
Patents
Methodology
List of Figures
Figure 1.1: Evolving trends in diagnostics
Figure 1.2: Key features of next generation omics-based diagnostic technologies
Figure 2.3: Key market drivers for biomarkers
Figure 2.4: Key market restraints for biomarkers
Figure 3.5: Key market drivers for microarrays & microfluidics
Figure 3.6: Key market restraints for microarrays & microfluidics
Figure 5.7: Key market drivers for bioinformatics
Figure 5.8: Key market restraints for bioinformatics
Figure 5.9: Evolution of bioinformatics
Figure 8.10: Diagnostic companies strategies
Figure 8.11: Recent developments: agreements & collaborations, 2008 - Jan 10
Figure 8.12: Mergers and acquisitions, 2008 - 09
Figure 9.13: Total number of patents registered, 2006-09
Figure 9.14: Patents by technology, 2006-09
Figure 9.15: Patents by geography, 2006-09
Figure 9.16: Patents by geography and technology, 2006-09
Figure 9.17: Patents by assignee, 2008
Figure 10.18: North American diagnostics market ($m), 2007-14
Figure 10.19: European diagnostics market($m), 2007-14
Figure 10.20: Asian diagnostics market($m), 2007-14
Figure 10.21: RoW diagnostics market ($m), 2007-14
List of Tables
Table 1.1: Global omics-based diagnostic technology market ($m), 2007-14
Table 2.2: Global biomarker market, by geography, ($m) 2007-14
Table 3.3: Global microarray market, by products, ($m) 2007-14
Table 3.4: Global microarray market, by geography, ($m) 2007-14
Table 3.5: Global DNA microarray market, by geography, ($m) 2007-14
Table 3.6: Global protein microarray market, by geography, ($m) 2007-14
Table 3.7: Global tissue/cell microarray market, by geography, ($m) 2007-14
Table 4.8: Global LOC market, by geography, ($m) 2007-14
Table 5.9: Global bioinformatics market, by geography, ($m) 2007-14
Table 6.10: Global qPCR market, by geography, ($m) 2007-14
Table 6.11: Global DNA biosensors market, by geography, ($m) 2007-14
Table 6.12: Global flow cytometry market, by geography, ($m) 2007-14
Table 6.13: Global DNA methylation market, by geography, ($m) 2007-14
Table 6.14: Global nanotechnology market, by geography, ($m) 2007-14
Table 7.15: Global diagnostics market, by utility, 2007-14 ($m)
Table 7.16: Global diagnostics market, by diseases, 2007-14 ($m)
Table 8.17: Details of recent agreements & collaborations
Table 8.18: Details of recent agreements & collaborations (ctd1)
Table 8.19: Details of recent agreements & collaborations (ctd2)
Table 8.20: Details of recent new product/service/technology launches
Table 8.21: Details of recent M&A activity
Table 10.22: Omics-based diagnostics market, by geography, ($m) 2007-14
Table 12.23: Japanese patents
Table 12.24: Japanese patents (ctd1)
Table 12.25: Japanese patents (ctd2)
Table 12.26: Japanese patents (ctd3)
Table 12.27: Japanese patents (ctd4)
Table 12.28: US patents
Table 12.29: US patents (ctd1)
Table 12.30: US patents (ctd2)
Table 12.31: US patents (ctd3)
Table 12.32: US patents (ctd4)
Table 12.33: US patents (ctd5)
Table 12.34: US patents (ctd6)
Table 12.35: US patents (ctd7)
Table 12.36: US patents (ctd8)
Table 12.37: US patents (ctd9)
Table 12.38: US patents (ctd10)
Table 12.39: US patents (ctd11)
Table 12.40: European patents
Table 12.41: European patents (ctd1)
Table 12.42: European patents (ctd2)
Table 12.43: European patents (ctd3)
Table 12.44: European patents (ctd4)
Table 12.45: European patents (ctd5)
Table 12.46: European patents (ctd6)
Table 12.47: European patents (ctd7)
Table 12.48: European patents (ctd8)