Global Markets for Media, Sera and Reagents in Biotechnology -- Focus on Emerging Markets

• The global market for media, sera and reagents used in biotechnology was valued at $2.3 billion in 2009, $2.5 billion in 2010 and is estimated to have reached nearly $2.8 billion at the end of 2011. The market is expected to reach $4.2 billion by 2016, a compound annual growth rate (CAGR) of 8.8%.
• The emerging markets for cell culture products totaled $128.7 million in 2009 and reached $134.8 million in 2010. This market is expected to increase from $141.5 million in 2011 to $178.3 million by 2016, at a CAGR of 4.7%.
• Cell culture media sales in the emerging markets amounted to $52.2 million in 2009 and reached $54.9 million in 2010. Increasing at a CAGR of 5.2% the cell culture media market is expected to grow from $57.9 million in 2011 to $74.5 million by 2016.

REPORT SCOPE

INTRODUCTION

STUDY OBJECTIVES

BCC’s goal in conducting this study is to provide an overview of the current and future characteristics of the global market for media, sera and the reagents used in biotechnology.  The key objective is to present a comprehensive analysis of the current market and its future direction in the media, sera and biotechnology reagents markets as an important tool for the cell culture industry.

This report explores present and future strategies within the media and sera market, including reagents used in biotechnology.  The improvisation of the market, the setbacks and the needs of the market are discussed in this report.  The types of cell cultures and the products from cell culture technology are also presented in this report.  The advantages and disadvantages for the use of various types of media are also covered in this report.

A detailed analysis of the cell culture industry structure has been conducted.  This includes the biotechnology reagents, media and the sera used.  Revenues are broken down by global region.  Sales figures are estimated for the five-year period from 2011 through 2016.

Applications for the cell culture industry—media, sera and reagents used in biotechnology—are also discussed in the report, with an emphasis on the usage in the research, production and contract segments.  The report also covers significant patents in each segment.

REASONS FOR DOING THIS STUDY

Demand for cell culture products, namely media, sera and reagents, is increasing, with the increasing demand for biopharmaceuticals.  Cell culture, a crucial component of the life sciences industry, has witnessed major development during the past three decades.  R&D spending, along with increasing competition, patent expiries, new technologies and an international marketplace are moving the cell culture process in a new direction.  As cell culture technologies evolved, a number of disciplines such as cell biology, genetic engineering, protein chemistry, genomics and chemical engineering have been successfully incorporated into the cell culture field.

Acquisition strategies and collaborations by companies are also covered in this report.  This study also discusses the strength and weaknesses of the different types of media used in light of the new technologies, growing competition and changing customer needs.

INTENDED AUDIENCE

This study contributes to the areas of market growth in the cell culture industry from the point of view of manufacturers and users.  Biotechnological companies, physicians, the pharmaceutical and biopharmaceutical industries, hospitals and research institutes will find this study to be of interest.

SCOPE OF THE STUDY

The scope of this study encompasses the biotechnology, pharmaceutical and medical markets.  BCC analyzes each market and its applications by its need for development of new medications through cell culture techniques, the regulatory environment, technology involved, market projections and market share.  Technological issues include the latest trends and developments.

METHODOLOGY

BCC conducted a comprehensive literature search, which included technical newsletters and journals, and many other sources.  Data was collected through interviews and correspondence with various analytical, chemical, pharmaceutical and biotechnical experts.  Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.

INFORMATION SOURCES

Many companies within the industry were surveyed to obtain data for this study.  Included were manufacturers and end users of biopharmaceuticals, and pharmaceutical companies through their production, research and contract manufacturing/research lines.  Data were gathered from various industry sources.  BCC spoke with officials and physicians within the industry, consulted newsletters, company literature, product literature and a host of technical articles, journals, indexes and abstracts.  Exhaustive investigations of databases by key terminology were completed.  In addition, data were compiled from current financial, trade and government sources.

ABOUT THE AUTHOR

The study has been carried out by a team of professionals in the biotechnology industry.  The project manager for this project is Shalini S. Dewan, who holds a Master’s degree in Pharmaceutical Chemistry and has more than 14 years of industry experience.  Among the research topics she has covered are studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid.  Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S.  Some of her other reports with BCC are Reagents for Chromatography; Spectroscopy, an Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.

The lead consultant for this project was Dr. Kapil A. Setia, who holds a doctoral degree in the life sciences.  She has a number of research publications to her credit.

Table Of Contents

Chapter- 1: INTRODUCTION - Complimentary 4
STUDY OBJECTIVES
REASONS FOR DOING THIS STUDY
INTENDED AUDIENCE
SCOPE OF THE STUDY
METHODOLOGY
INFORMATION SOURCES
ABOUT THE AUTHOR
RELATED BCC RESEARCH REPORTS
BCC ONLINE SERVICES
DISCLAIMER

Chapter- 2: EXECUTIVE SUMMARY 3
Table Summary : GLOBAL REVENUES FROM MEDIA, SERA AND REAGENTS USED IN THE BIOTECHNOLOGY MARKET, THROUGH 2016
Figure Summary : GLOBAL REVENUES FROM MEDIA, SERA AND REAGENTS USED IN THE BIOTECHNOLOGY MARKET, 2009-2016

Chapter- 3: OVERVIEW 64
DEFINITIONS
HISTORY
TYPES OF CELL CULTURES
MORPHOLOGY OF CELLS IN CULTURE
BASIC SYSTEMS FOR CELL CULTURE
CELL LINE, CELL STRAIN AND TRANSFORMED CELL LINES
FACTORS AFFECTING CELL CULTURE
APPLICATIONS OF CELL CULTURE
PROBLEMS DURING CELL CULTURE
BASIC REQUIREMENTS OF CELL CULTURE
REGULATORY ASPECTS
APPROVALS OF BIOLOGICAL LICENSE APPLICATIONS
ADMINISTRATIVE ACTIONS: BIOLOGICS
LEADING MANUFACTURERS OF MEDIA
NEW DEVELOPMENTS
NEW DEVELOPMENTS IN APPLICATIONS
Table 24 : NEW DEVELOPMENTS IN APPLICATION OF CELL CULTURE

Chapter- 4: GLOBAL MARKETS 33
MEDIA
SERA
REAGENTS

Chapter- 5: EMERGING MARKETS/REST OF THE WORLD MARKET 26
MEDIA
SERA
REAGENTS
MARKET LEADERS IN THE EMERGING MARKETS

Chapter- 6: END USERS 14
MARKET SHARE OF APPLICATIONS
RESEARCH SEGMENT
PRODUCTION SEGMENT
CONTRACT SEGMENT
OTHERS SEGMENT

Chapter- 7: PATENT ANALYSIS 6
PATENTS BY YEAR
PATENTS BY TYPE
PATENTS BY COMPANY
PATENTS BY COUNTRY
PATENTS BY ASSIGNEE
Table 75 : U.S. PATENTS ISSUED FOR MEDIA, SERA AND REAGENTS USED IN BIOTECHNOLOGY BY TYPE OF END USER, 2007 TO OCT. 2011

Chapter- 8: THE CURRENT SITUATION 9
REGIONAL MARKETS
TRENDS AND ISSUES IN THE CELL CULTURE MARKET

Chapter- 9: COMPANY PROFILES 23
ADVANCED BIOTECHNOLOGIES INC.
AFFYMETRIX
AMRESCO LLC
ATHENA ENVIRONMENTAL SCIENCES INC.
ATLANTA BIOLOGICALS INC.
BD BIOSCIENCES
BIORECLAMATION INC.
BOVOGEN BIOLOGICALS PTY. LTD.
CELL APPLICATIONS INC.
CELL CULTURE TECHNOLOGIES GMBH
CLONTECH LABORATORIES INC.
EQUITECH-BIO INC.
GEMINI BIO-PRODUCTS
GENEX INDIA BIOSCIENCES PVT. LTD.
HIMEDIA LABORATORIES
INVITROGEN CORP.
IRVINE SCIENTIFIC
J R SCIENTIFIC INC.
LONZA
MEDIATECH INC.
MEDOX BIOTECH INDIA PVT. LTD.
MILLIPORE CORP.
MP BIOMEDICALS
PAA LABORATORIES
PEPROTECH INC.
PROMOCELL GMBH
QUALITY BIOLOGICAL INC.
R&D SYSTEMS
ROCHE APPLIED SCIENCES
SERA LABORATORIES INTERNATIONAL LTD.
SERACARE LIFE SCIENCES INC.
SIGMA-ALDRICH
STEMCELL TECHNOLOGIES
STEMCELLS INC.
THERMO FISHER SCIENTIFIC INC.
TICO EUROPE
VALLEY BIOMEDICAL PRODUCTS AND SERVICES INC.

Chapter- 10: APPENDIX: ABBREVIATIONS 3

List of Tables

Summary Table : GLOBAL REVENUES FROM MEDIA, SERA AND REAGENTS USED IN THE BIOTECHNOLOGY MARKET, THROUGH 2016
Table 1 : HISTORICAL EVENTS IN CELL CULTURE DEVELOPMENT
Table 2 : ADVANTAGES AND DISADVANTAGES OF PRIMARY CELL CULTURE
Table 3 : ADVANTAGES AND DISADVANTAGES OF CONTINUOUS CELL CULTURE
Table 4 : ADHERENT CULTURE VS. SUSPENSION CULTURE
Table 5 : CULTURE MEDIA USED FOR THE PRODUCTION OF VACCINES
Table 6 : POTENTIAL SOURCES OF CELL CULTURE ADDITIVES
Table 7 : RECOMBINANT THROMBOLYTIC AGENTS
Table 8 : RECOMBINANT COAGULATION FACTOR
Table 9 : THE ROLES OF DIFFERENT INORGANIC NUTRIENTS
Table 10 : COMMONLY USED ANTIBIOTICS IN CELL CULTURES
Table 11 : ADVANTAGES AND DISADVANTAGES OF SERUM-CONTAINING MEDIA
Table 12 : ADVANTAGES AND DISADVANTAGES OF SERUM-FREE MEDIA
Table 13 : NORMAL RANGE OF CONCENTRATION OF SERUM CONSTITUENTS
Table 14 : APPROVALS OF BIOLOGICAL LICENSE APPLICATIONS, 2010 TO AUG. 2011
Table 15 : ADMINISTRATIVE ACTIONS: BIOLOGICS, 2007 TO AUG. 2011
Table 16 : PRODUCT RECALLS, 2007 TO AUG. 2011
Table 17 : LEADING MANUFACTURERS OF MEDIA
Table 18 : LEADING MANUFACTURERS OF SERA
Table 19 : LEADING MANUFACTURERS OF BIOLOGIC RESPONSE MODIFIERS
Table 20 : LEADING MANUFACTURERS OF CELL DISSOCIATION REAGENTS
Table 21 : LEADING MANUFACTURERS OF ANTIBIOTICS AND ANTIMYCOTICS USED IN CELL CULTURE
Table 22 : LEADING MANUFACTURERS OF OTHER REAGENTS
Table 23 : NEW DEVELOPMENTS IN THE CELL CULTURE INDUSTRY SINCE 2008
Table 24 : NEW DEVELOPMENTS IN APPLICATION OF CELL CULTURE
Table 25 : GLOBAL MARKET FOR CELL CULTURE PRODUCTS, THROUGH 2016
Table 26 : GLOBAL MARKET FOR MEDIA USED IN BIOTECHNOLOGY BY REGION, THROUGH 2016
Table 27 : GLOBAL BIOTECHNOLOGY MEDIA MARKET SHARES BY REGION, 2010
Table 28 : GLOBAL MARKET FOR SERUM-FREE MEDIA BY REGION, THROUGH 2016
Table 29 : GLOBAL MARKET FOR SERUM-REQUIRING MEDIA BY REGION, THROUGH 2016
Table 30 : GLOBAL MARKET FOR POWDERED MEDIA, THROUGH 2016
Table 31 : GLOBAL MARKET FOR LIQUID MEDIA BY REGION, THROUGH 2016
Table 32 : GLOBAL MARKET FOR CLASSICAL MEDIA BY REGION, THROUGH 2016
Table 33 : GLOBAL MARKET FOR SPECIALTY MEDIA BY REGION, THROUGH 2016
Table 34 : GLOBAL MARKET FOR SERA BY REGION, THROUGH 2016
Table 35 : GLOBAL SERA MARKET SHARES BY REGION, 2010
Table 36 : GLOBAL MARKET FOR BOVINE SERA BY REGION, THROUGH 2016
Table 37 : GLOBAL MARKET FOR OTHER SERA BY REGION, THROUGH 2016
Table 38 : GLOBAL MARKET FOR CELL CULTURE REAGENTS BY REGION, THROUGH 2016
Table 39 : GLOBAL CELL CULTURE REAGENT MARKET SHARES BY REGION, 2010
Table 40 : GLOBAL MARKET FOR BIOLOGICAL RESPONSE MODIFIERS BY REGION, THROUGH 2016
Table 41 : GLOBAL MARKET FOR GROWTH FACTORS BY REGION, THROUGH 2016
Table 42 : GLOBAL MARKET FOR CYTOKINES BY REGION, THROUGH 2016
Table 43 : GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE MODIFIERS BY REGION, THROUGH 2016
Table 44 : GLOBAL MARKET FOR CELL DISSOCIATION REAGENTS BY REGION, THROUGH 2016
Table 45 : GLOBAL MARKET FOR OTHERS BY REGION, THROUGH 2016
Table 46 : EMERGING MARKETS FOR CELL CULTURE PRODUCTS, THROUGH 2016
Table 47 : EMERGING MARKETS FOR CELL CULTURE MEDIA, THROUGH 2016
Table 48 : EMERGING MARKETS FOR SERUM-REQUIRING AND SERUM-FREE MEDIA, THROUGH 2016
Table 49 : EMERGING MARKETS FOR POWDERED AND LIQUID MEDIA, THROUGH 2016
Table 50 : EMERGING MARKETS FOR CLASSICAL AND SPECIALTY MEDIA, THROUGH 2016
Table 51 : EMERGING MARKETS FOR BOVINE AND OTHER SERA, THROUGH 2016
Table 52 : EMERGING MARKETS FOR CELL CULTURE REAGENTS, THROUGH 2016
Table 53 : EMERGING MARKETS FOR BIOLOGICAL RESPONSE MODIFIERS, THROUGH 2016
Table 54 : MARKET SHARES OF SERUM FREE MEDIA IN THE EMERGING MARKETS BY COMPANY, 2010
Table 55 : MARKET SHARES OF SERUM-CONTAINING MEDIA IN THE EMERGING MARKETS BY COMPANY, 2010
Table 56 : MARKET SHARES OF POWDERED MEDIA IN THE EMERGING MARKETS BY COMPANY, 2010
Table 57 : MARKET SHARES OF LIQUID MEDIA IN THE EMERGING MARKETS BY COMPANY, 2010
Table 58 : MARKET SHARES OF CLASSICAL MEDIA IN THE EMERGING MARKETS BY COMPANY, 2010
Table 59 : MARKET SHARES OF SPECIALTY MEDIA IN THE EMERGING MARKETS BY COMPANY, 2010
Table 60 : MARKET SHARES OF BOVINE SERA IN THE EMERGING MARKETS BY COMPANY, 2010
Table 61 : MARKET SHARES OF OTHER SERA IN THE EMERGING MARKETS BY COMPANY, 2010
Table 62 : MARKET SHARES OF BIOLOGICAL RESPONSE MODIFIERS IN THE EMERGING MARKETS BY COMPANY, 2010
Table 63 : MARKET SHARES OF CELL DISSOCIATION REAGENTS IN THE EMERGING MARKETS BY COMPANY, 2010
Table 64 : MARKET SHARES OF OTHER REAGENTS IN THE EMERGING MARKETS BY COMPANY, 2010
Table 65 : GLOBAL MEDIA, SERA AND REAGENT MARKET SHARES BY END USER, 2010
Table 66 : GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN THE RESEARCH SEGMENT, THROUGH 2016
Table 67 : GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN THE PRODUCTION SEGMENT, THROUGH 2016
Table 68 : GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN THE CONTRACT SEGMENT, THROUGH 2016
Table 69 : GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN THE OTHERS SEGMENT, THROUGH 2016
Table 70 : NUMBER OF U.S. PATENTS ISSUED BY YEAR, 2007 TO OCT. 2011
Table 71 : PATENTS BY TYPE FOR MEDIA, SERA AND REAGENTS USED IN BIOTECHNOLOGY, 2007–2011
Table 72 : U.S. PATENTS ISSUED FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY BY COMPANY, 2007 TO OCT. 2011
Table 73 : U.S. PATENTS ISSUED FOR MEDIA, SERA AND REAGENTS USED IN BIOTECHNOLOGY BY COUNTRY, 2007 TO OCT. 2011
Table 74 : SHARES OF U.S. PATENTS ISSUED FOR MEDIA, SERA AND REAGENTS USED IN BIOTECHNOLOGY BY COUNTRY, 2007–OCT. 2011
Table 75 : U.S. PATENTS ISSUED FOR MEDIA, SERA AND REAGENTS USED IN BIOTECHNOLOGY BY TYPE OF END USER, 2007 TO OCT. 2011
Table 76 : R&D BUDGETS OF TOP 10 COMPANIES IN 2009 AND 2010

List of Figures

Summary Figure : GLOBAL REVENUES FROM MEDIA, SERA AND REAGENTS USED IN THE BIOTECHNOLOGY MARKET, 2009-2016
Figure 1 : GLOBAL MARKET FOR CELL CULTURE PRODUCTS, 2009-2016
Figure 2 : GLOBAL MARKET FOR MEDIA USED IN BIOTECHNOLOGY BY REGION, 2009-2016
Figure 3 : GLOBAL BIOTECHNOLOGY MEDIA MARKET SHARES BY REGION, 2010
Figure 4 : GLOBAL MARKET FOR SERUM-FREE MEDIA BY REGION, 2009-2016
Figure 5 : GLOBAL MARKET FOR SERUM-REQUIRING MEDIA BY REGION, 2009-2016
Figure 6 : GLOBAL MARKET FOR POWDERED MEDIA, 2009-2016
Figure 7 : GLOBAL MARKET FOR LIQUID MEDIA BY REGION, 2009-2016
Figure 8 : GLOBAL MARKET FOR CLASSICAL MEDIA BY REGION, 2009–2016
Figure 9 : GLOBAL MARKET FOR SPECIALTY MEDIA BY REGION, 2009-2016
Figure 10 : GLOBAL MARKET FOR SERA BY REGION, 2009–2016
Figure 11 : GLOBAL SERA MARKET SHARES BY REGION, 2010
Figure 12 : GLOBAL MARKET FOR BOVINE SERA BY REGION, 2009–2016
Figure 13 : GLOBAL MARKET FOR OTHER SERA BY REGION, 2009-2016
Figure 14 : GLOBAL MARKET FOR CELL CULTURE REAGENTS BY REGION, 2009-2016
Figure 15 : GLOBAL CELL CULTURE REAGENT MARKET SHARES BY REGION, 2010
Figure 16 : GLOBAL MARKET FOR BIOLOGICAL RESPONSE MODIFIERS BY REGION, 2009-2016
Figure 17 : GLOBAL MARKET FOR GROWTH FACTORS BY REGION, 2009- 2016
Figure 18 : GLOBAL MARKET FOR CYTOKINES BY REGION, 2009-2016
Figure 19 : GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE MODIFIERS BY REGION, 2009-2016
Figure 20 : GLOBAL MARKET FOR CELL DISSOCIATION REAGENTS BY REGION, 2009-2016
Figure 21 : GLOBAL MARKET FOR OTHERS BY REGION, 2009-2016
Figure 22 : EMERGING MARKETS FOR CELL CULTURE PRODUCTS, 2009-2016
Figure 23 : EMERGING MARKETS FOR CELL CULTURE MEDIA, 2009-2016
Figure 24 : EMERGING MARKETS FOR SERUM-REQUIRING AND SERUM-FREE MEDIA, THROUGH 2016
Figure 25 : EMERGING MARKETS FOR POWDERED AND LIQUID MEDIA, 2009-2016
Figure 26 : EMERGING MARKETS FOR CLASSICAL AND SPECIALTY MEDIA, 2009 2016
Figure 27 : EMERGING MARKETS FOR BOVINE AND OTHER SERA, 2009-2016
Figure 28 : EMERGING MARKETS FOR CELL CULTURE REAGENTS, 2009-2016
Figure 29 : EMERGING MARKETS FOR BIOLOGICAL RESPONSE MODIFIERS, 2009-2016
Figure 30 : MARKET SHARES OF SERUM FREE MEDIA IN THE EMERGING MARKETS BY COMPANY, 2010
Figure 31 : MARKET SHARES OF SERUM CONTAINING MEDIA IN THE EMERGING MARKETS BY COMPANY, 2010
Figure 32 : MARKET SHARES OF POWDERED MEDIA IN THE EMERGING MARKETS BY COMPANY, 2010
Figure 33 : MARKET SHARES OF LIQUID MEDIA IN THE EMERGING MARKETS BY COMPANY, 2010
Figure 34 : MARKET SHARES OF CLASSICAL MEDIA IN THE EMERGING MARKETS BY COMPANY, 2010
Figure 35 : MARKET SHARES OF SPECIALTY MEDIA IN THE EMERGING MARKETS BY COMPANY, 2010
Figure 36 : MARKET SHARES OF BOVINE SERA IN THE EMERGING MARKETS BY COMPANY, 2010
Figure 37 : MARKET SHARES OF OTHER SERA IN THE EMERGING MARKETS BY COMPANY, 2010
Figure 38 : MARKET SHARES OF BIOLOGICAL RESPONSE MODIFIERS IN THE EMERGING MARKETS BY COMPANY, 2010
Figure 39 : MARKET SHARES OF CELL DISSOCIATION REAGENTS IN THE EMERGING MARKETS BY COMPANY, 2010
Figure 40 : MARKET SHARES OF OTHER REAGENTS IN THE EMERGING MARKETS BY COMPANY, 2010
Figure 41 : GLOBAL MEDIA, SERA AND REAGENT MARKET SHARES BY END USER, 2010
Figure 42 : GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN THE RESEARCH SEGMENT, 2009-2016
Figure 43 : GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN THE PRODUCTION SEGMENT, 2009-2016
Figure 44 : GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN THE CONTRACT SEGMENT, 2009-2016
Figure 45 : GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN THE OTHERS SEGMENT, 2009-2016
Figure 46 : U.S. PATENTS ISSUED BY YEAR, 2007 TO OCT. 2011
Figure 47 : PATENTS BY TYPE FOR MEDIA, SERA AND REAGENTS USED IN BIOTECHNOLOGY, 2007–2011