Cancer Monoclonal Antibody Partnering Terms and Agreements

Published: May 2013
No. of Pages: 583
  

The Cancer Monoclonal Antibody Partnering Agreements report provides an understanding and access to the cancer monoclonal antibody partnering deals and agreements entered into by the worlds leading healthcare companies.

  • Trends in cancer monoclonal antibody partnering deals
  • Disclosed headlines, upfronts, milestones and royalties by stage of development
  • Cancer monoclonal antibody partnering contract documents
  • Top cancer monoclonal antibody deals by value

The Cancer Monoclonal Antibody Partnering Agreements report provides an understanding and access to the cancer monoclonal antibody partnering deals and agreements entered into by the worlds leading healthcare companies.

The report provides an understanding and analysis of how and why companies enter cancer monoclonal antibody partnering deals. The majority of deals are discovery or development stage whereby the licensee obtains a right or an option right to license the licensors monoclonal antibody technology. These deals tend to be multicomponent, starting with collaborative R&D, and commercialization of outcomes. The report also includes antibody-drug conjugate deals and alliances.

Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered – contract documents provide this insight where press releases do not.

This report contains over 450 links to online copies of actual cancer monoclonal antibody deals and where available, contract documents as submitted to the Securities Exchange Commission by companies and their partners. Contract documents provide the answers to numerous questions about a prospective partner’s flexibility on a wide range of important issues, many of which will have a significant impact on each party’s ability to derive value from the deal.

The initial chapters of this report provide an orientation of cancer monoclonal antibody dealmaking and business activities.

Chapter 1 provides an introduction to the report, whilst

Chapter 2 provides an overview of the trends in cancer monoclonal antibody dealmaking since 2007, including details of average headline, upfront, milestone and royalty terms.

Chapter 3 provides a review of the leading cancer monoclonal antibody deals since 2007. Deals are listed by headline value, signed by bigpharma, most active bigpharma, and most active of all biopharma companies. Where the deal has an agreement contract published at the SEC a link provides online access to the contract.

Chapter 4 provides a comprehensive and detailed review of cancer monoclonal antibody partnering deals signed and announced since January 2007, where a contract document is available in the public domain. The chapter is organized by company A-Z, stage of development at signing, deal type (collaborative R&D, co-promotion, licensing etc), specific therapy focus, and antibody technology type. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.

The report also includes numerous tables and figures that illustrate the trends and activities in cancer monoclonal antibody partnering and dealmaking since 2007.

In conclusion, this report provides everything a prospective dealmaker needs to know about partnering in the research, development and commercialization of cancer monoclonal antibody technologies and products.

Report scope

Cancer Monoclonal Antibody Partnering Agreements is intended to provide the reader with an in-depth understanding and access to cancer monoclonal antibody trends and structure of deals entered into by leading companies worldwide.

Cancer Monoclonal Antibody Partnering Agreements includes:

  • Trends in cancer monoclonal antibody dealmaking in the biopharma industry since 2007
  • Analysis of cancer monoclonal antibody deal structure
  • Access to headline, upfront, milestone and royalty data
  • Access to over 450 cancer monoclonal antibody deal records
  • The leading cancer monoclonal antibody deals by value since 2007
  • Includes antibody-drug conjugates deals and alliances since 2007

In Cancer Monoclonal Antibody Partnering Agreements, the available deals are listed by:

  • Company A-Z
  • Headline value
  • Stage of development at signing
  • Deal component type
  • Specific oncology therapy target
  • Monoclonal antibody type

Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.

The Cancer Monoclonal Antibody Partnering Agreements report provides comprehensive access to available deals and contract documents for over 1,000 cancer monoclonal antibody deals. Analyzing actual contract agreements allows assessment of the following:

  • What are the precise rights granted or optioned?
  • What is actually granted by the agreement to the partner company?
  • What exclusivity is granted?
  • What is the payment structure for the deal?
  • How aresales and payments audited?
  • What is the deal term?
  • How are the key terms of the agreement defined?
  • How are IPRs handled and owned?
  • Who is responsible for commercialization?
  • Who is responsible for development, supply, and manufacture?
  • How is confidentiality and publication managed?
  • How are disputes to be resolved?
  • Under what conditions can the deal be terminated?
  • What happens when there is a change of ownership?
  • What sublicensing and subcontracting provisions have been agreed?
  • Which boilerplate clauses does the company insist upon?
  • Which boilerplate clauses appear to differ from partner to partner or deal type to deal type?
  • Which jurisdiction does the company insist upon for agreement law?

Benefits

Cancer Monoclonal Antibody Partnering Agreements provides the reader with the following key benefits:

  • In-depth understanding of cancer monoclonal antibody deal trends since 2007
  • Access to headline, upfront, milestone and royalty data
  • Acces to the structure of cancer monoclonal antibody agreements with numerous real life case studies
  • Comprehensive access to over 450 actual cancer monoclonal antibody deals entered into by the world’s biopharma companies
  • Insight into the terms included in a cancer monoclonal antibody agreement, together with real world clause examples
  • Understand the key deal terms companies have agreed in previous deals
  • Undertake due diligence to assess suitability of your proposed deal terms for partner companies

Cancer Monoclonal Antibody Partnering Terms and Agreements

Table Of Contents

Executive Summary

Chapter 1 – Introduction

Chapter 2 – Trends In Cancer Monoclonal Antibody Dealmaking

2.1. Introduction
2.2. Cancer monoclonal antibody partnering over the years
2.3. Bigpharma cancer monoclonal antibody dealmaking activity
2.4. Bigpharma not active in cancer monoclonal antibody partnering
2.5. Most active in cancer monoclonal antibody partnering
2.6. Cancer monoclonal antibody partnering by deal type
2.7. Cancer monoclonal antibody partnering by stage of development
2.8. Cancer monoclonal antibody partnering by cancer indication
2.9. Cancer monoclonal antibody partnering by antibody type
2.10. Disclosed deal terms for cancer monoclonal antibody partnering
2.10.1 Cancer monoclonal antibody partnering headline values
2.10.2 Cancer monoclonal antibody deal upfront payments
2.10.3 Cancer monoclonal antibody deal milestone payments
2.10.4 Cancer monoclonal antibody royalty rates

Chapter 3 – Leading Cancer Monoclonal Antibody Deals
3.1. Introduction
3.2. Top cancer monoclonal antibody deals by value

Chapter 4 – Cancer Monoclonal Antibody Dealmaking Directory
4.1. Introduction
4.2. Company A-Z
3M
4-Antibody
A*STAR Agency for Science, Technology and Research
A*STAR Bioprocessing Technology Institute
A-CUBE
AaiPharma
Abbott Laboratories
AbbVie
Abdi Ibrahim
Abeome
Ablynx
Acceptys
Actinium Pharmaceuticals
AdnaGen
Advanced Accelerator Applications (AAA)
Affitech
Affomix
Agence Nationale de Recherches sur le SIDA et les hepatitives virales
Agensys
AIMM Therapeutics
Alethia Biotherapeutics
Alexion Pharmaceuticals
Alexis Biotech
Algeta
Alligator Bioscience
Allphase Clinical Research Services
Altor BioScience
Amgen
Amorfix Life Sciences
AnaptysBio
Antisoma
Antitope
Apeiron Biologics
Apexigen
Applied Genomics
Aragen Bioscience
Arana Therapeutics
Areva Med
Arius Research
Astellas
AstraZeneca
Atlab Pharma
Aventis
AVEO Pharmaceuticals
Avid Bioservices
AZ Sint Lucas Hospital
BAC
Baize Investments
Bayer
Bayer Healthcare
Bayer Schering Pharma
Baylor College
Baylor Research Institute
BeiGene
Biocare Medical
Bioceros
Biocon Group
Biogen  Idec International
Biogen Idec
BioInvent
Biolex
Biosite
Biotech Investment
Biothera
BioWa
Boehringer Ingelheim
Bristol-Myers Squibb
BZL Biologics
Caliber Biotherapeutics
Cambridge Biomedical
Cancer Innovations
Cancer Research Institute
Cancer Research Technology
CancerVax
Caprion Proteomics
Catalent Pharma Solutions
Cato Research
Celgene
Cell-Matrix
Cell Signaling Technology
Cell Therapeutics
Celldex Therapeutics
Celltrion
Centocor
Centocor Ortho Biotech
Cephalon Australia
CG Therapeutics
Champions Oncology
Chemo Sa Lugano
Children´s Oncology Group (COG)
Children’s Cancer Research Institute (CCRI)
China Synthetic Rubber
Chinese Academy of Medical Sciences
Chinese Academy of Sciences
Chiome Bioscience
Chugai Pharmaceutical
CIMAB SA
Cimym
City of Hope
City University of New York Center for Advanced Technology
Clarity Pharmaceuticals
Clavis Pharma
Clinical Data
CMC Biopharmaceuticals
CMC ICOS Biologics
Cobra Biologics
Coherus Biosciences
Compugen
Coriell Institute for Medical Research
Cormorant Pharmaceuticals
Cosmo Pharmaceuticals
Covance
Crucell
CSL
Cytovance Biologics
Daiichi Sankyo
Dako
Dana-Farber Cancer Institute
Debiopharm
Debiovision
Defense Threat Reduction Agency
Dios Therapeutics
Diversa
Domainex
Dompe Farmaceutici
DSM Biologics
DSM Pharmaceutical Products
Dyax
Echelon Biosciences
Eclipse Aesthetics
Eli Lilly
Emergent BioSolutions
Emory University
Enlyten Medical Technologies
Epitome Biosystems
Epitomics
Eurogentec
EvoGenix
ExonHit Therapeutics
Facet Biotechnology
Faron Pharmaceuticals
Favrille
Ferozsons Laboratories
Five Prime Therapeutics
Florida Biologix
Fred Hutchinson Cancer Research Center
Fresenius Biotech
Fusion Antibodies
Galena Biopharma
Genentech
Genmab
Genome Institute of Singapore
Genzyme
George Mason University
Georgia Research Alliance (GRA)
German Cancer Research Center
Gilead Sciences
GlaxoSmithKline
Gliknik
GlycArt
Goodwin Biotechnology
Green Cross
Greenovation Biotech
Groupe d'Etude des Lymphomes de l'Adulte (GELA)
GSK Clinical Imaging Centre
GTC Biotherapeutics
Hawthorn Pharmaceuticals
HemispheRx Biopharma
Hokkaido University
Human Genome Sciences
Human Monoclonals International
IBio
Ildong Pharmaceutical
ImaginAb
ImClone Systems
Immune Pharmaceuticals
ImmunGene
ImmunoCellular Therapeutics
ImmunoGen
Immunomedics
Innate Immune
Innate Pharma
Innexus
InnoKeys
InnoMab
Inserm
Institute of Hematology and Blood Diseases Hospital
Integral Molecular
Janssen Biotech
Janssen Pharmaceutica NV
Jantibody Therapeutics
Jinfiniti Biosciences
Johns Hopkins Medicine (JHM)
Johnson & Johnson
Kadmon Pharmaceuticals
Kalgene Pharmaceuticals
KellBenx
Kissei Pharmaceutical
Kyowa Hakko Kogyo
Kyto Biopharma
Lab21
Laureate Pharmaceuticals
Leukemia & Lymphoma Society
LFB Biotechnologies
Life Science Pharmaceuticals
Life Technologies Corporation
Ligacept
Lonza
Lpath
Ludwig Institute for Cancer Research
MabCure
MabVax Therapeutics
Macrogenics
Maine Medical Center
Mantecorp
Mat Biopharma
MD Anderson Cancer Center
Medarex
Medical College of Georgia
Medical Research Council
MediGene
MedImmune
Memorial Sloan Kettering Cancer Center
Menarini
MENTRIK Biotech
Mercator Therapeutics
Merck & Co
Merck KGaA
Merck Serono
Merrimack Pharmaceuticals
Merus
Micromet
MilleGen
Millennium
Ministry of Health, Labor and Welfare
Molecular Discoveries
Monogram Biosciences
Montefiore Medical Center
MorphoSys
Morphotek
MRC Technology
MSM Protein Technologies
Nascent Biologics
Natco Pharmaceuticals
National Cancer Institute
National Comprehensive Cancer Network (NCCN)
National Institutes of Health
National Research Council Biotechnology Research Institute
NauchTekhStroy Plus
Navidea Biopharmaceuticals
Neogenix Oncology
Neoprobe
NKT Therapeutics
Northwestern University
Novartis
Novartis Venture Funds
Novo Nordisk
Nycomed
OcellO
Octapharma
Office of the Chief Scientist
Oklahoma Medical Research Foundation
Oncobiologics
OncoMab
OncoMax
OncoMed Pharmaceuticals
Oncoscience AG
Ophthotech
Organon
Otsuka
Oxford BioTherapeutics
Oxford Genome Sciences
PacificGMP
Paladin Labs
Patrys
PDL BioPharma
Peptech
Percipio Biotherapeutics
Peregrine Pharmaceuticals
Pfenex
Pfizer
PGxHealth
Philogen
Pierre Fabre
Pikamab
Pivotal Biosciences
Precision Antibody
PRIMA BioMed
Prometheus
Provenance Biopharmaceuticals
Q Therapeutics
QED Bioscience
Quest PharmaTech
Ramot at Tel Aviv University
Raven Biotechnologies
RayBiotech
Recepta Biopharma
Research Foundation of State University of New York
RIT Oncology
Roche
Rockland Immunochemicals
Roswell Park Cancer Institute
SAIC-Frederick
Sanofi-Aventis
Scancell
Schering-Plough
SDIX
Seattle Genetics
Serono
Servier
Shanghai ChemPartner
Shanghai Duyiwei Biotech
Shenogen Pharma
Siena Biotech
Sigma-Aldrich
Simcere Pharmaceuticals
Society of Paediatric Oncology European Neuroblastoma Network (SIOPEN)
Spectrum Pharmaceuticals
Stanford University
Stason Pharmaceuticals
STC Biologics
Stonsa Biopharm
Structural Genomics
Structural Genomics Consortium
Sutro Biopharma
Swedish Orphan Biovitrum
Symphogen
Synageva BioPharma
SynCo Bio Partners
Synthon
Systems Medicine
Takeda Pharmaceutical
Targepeutics
Targeted Payload Therapeutics
Tasly Pharmaceuticals
TenX Biopharma
Teva Pharmaceuticals
TG Therapeutics
Theraclone Sciences
Therapure Biopharma
ThromboGenics
ToleRx
TRACON Pharmaceuticals
Transgene
Transgenomic
UCB
University Hospital Heidelberg
University Hospital of Parma
University of California San Francisco (UCSF)
University of Chicago
University of North Carolina
University of Pennsylvania
University of Pittsburgh
University of Southampton
University of Toronto
University of Washington
University of Wurzburg
Vaccinex
Valor Biotherapeutics
Vegenics
Ventana Medical Systems
ViroMed
Viropro
Vivalis
VivoPharm
VLST Corporation
Wakunaga Pharmaceuticals
Watson Pharmaceuticals
Wilex
Wistar Institute
Wyeth
X-Body Biosiences
Xencor
Xoma
YM BioSciences
4.3. By stage of development
Discovery
Preclinical
Phase I
Phase II
Phase III
Regulatory
Marketed
Formulation
4.4. By deal type
Asset purchase
Assignment
Bigpharma outlicensing
Co-development
Collaborative R&D
Co-market
Contract service
Co-promotion
CRADA
Cross-licensing
Development
Distribution
Equity purchase
Evaluation
Grant
Joint venture
Licensing
Loan
Manufacturing
Marketing
Material transfer
Option
Promotion
Research
Settlement
Spin out
Sub-license
Supply
Technology transfer
Termination
4.5. By oncology therapy area
Oncology
4.6. By antibody type

Chapter 5 –Partnering Resource Center
5.1. Online partnering
5.2. Partnering events
5.3. Further reading on dealmaking

Appendices
Appendix 1 – Deal type definitions
Appendix 2 – Example monoclonal antibody cancer partnering agreement
About Wildwood Ventures
Current Partnering
Current Agreements
Recent report titles from CurrentPartnering
Order Form – Technology Reports
Order Form – Therapy Reports

List Of Figures

Figure 1: Cancer monoclonal antibody partnering since 2007
Figure 2: Bigpharma – top 50 – cancer monoclonal antibody deals 2007 to 2013
Figure 3: Bigpharma cancer monoclonal antibody deal frequency – 2007 to 2013
Figure 4: Inactive bigpharma in cancer monoclonal antibody partnering 2007-2012
Figure 5: Active cancer monoclonal antibody dealmaking activity– 2007 to 2013
Figure 6: Cancer monoclonal antibody partnering by deal type since 2007
Figure 7: Cancer monoclonal antibody partnering by stage of development since 2007
Figure 8: Monoclonal antibody partnering by oncology target since 2007
Figure 9: Monoclonal antibody partnering by type since 2007
Figure 10: Cancer monoclonal antibody deals with a headline value – by stage of development
Figure 11: Cancer monoclonal antibody deal headline value distribution, US$million – discovery stage
Figure 12: Cancer monoclonal antibody deal headline value distribution, US$million – preclinical stage
Figure 13: Cancer monoclonal antibody deal headline value distribution, US$million – phase I stage
Figure 14: Cancer monoclonal antibody deal headline value distribution, US$million – phase II stage
Figure 15: Cancer monoclonal antibody deal headline value distribution, US$million – phase III stage
Figure 16: Cancer monoclonal antibody deal headline value distribution, US$million – regulatory stage
Figure 17: Cancer monoclonal antibody deal headline value distribution, US$million – marketed stage
Figure 18: Cancer monoclonal antibody deal headline value – median value by stage of development
Figure 19: Cancer monoclonal antibody deals with upfront payment values – by stage of development
Figure 20: Cancer monoclonal antibody deal upfront distribution, US$million – discovery stage
Figure 21: Cancer monoclonal antibody deal upfront value distribution, US$million – preclinical stage
Figure 22: Cancer monoclonal antibody deal upfront value distribution, US$million – phase I stage
Figure 23: Cancer monoclonal antibody deal upfront value distribution, US$million – phase II stage
Figure 24: Cancer monoclonal antibody deal upfront value distribution, US$million – phase III stage
Figure 25: Cancer monoclonal antibody deal upfront value distribution, US$million – regulatory stage
Figure 26: Cancer monoclonal antibody deal upfront value distribution, US$million – marketed stage
Figure 27: Cancer monoclonal antibody deal upfront value – median value by stage of development
Figure 28: Cancer monoclonal antibody deals with milestone payment – by stage of development
Figure 29: Cancer monoclonal antibody deal milestone distribution, US$million – discovery stage
Figure 30: Cancer monoclonal antibody deal milestone value distribution, US$million – preclinical stage
Figure 31: Cancer monoclonal antibody deal milestone value distribution, US$million – phase I stage
Figure 32: Cancer monoclonal antibody deal milestone value distribution, US$million – phase II stage
Figure 33: Cancer monoclonal antibody deal milestone value distribution, US$million – phase III stage
Figure 34: Cancer monoclonal antibody deal milestone value distribution, US$million – regulatory stage
Figure 35: Cancer monoclonal antibody deal milestone value distribution, US$million – marketed stage
Figure 36: Cancer monoclonal antibody deals with royalty rates
Figure 37: Cancer monoclonal antibody deal royalty rate distribution, US$million – discovery stage
Figure 38: Cancer monoclonal antibody deal royalty rate value distribution, US$million – preclinical stage
Figure 39: Cancer monoclonal antibody deal royalty rate value distribution, US$million – phase I stage
Figure 40: Cancer monoclonal antibody deal royalty rate value distribution, US$million – phase II stage
Figure 41: Cancer monoclonal antibody deal royalty rate value distribution, US$million – phase III stage
Figure 42: Cancer monoclonal antibody deal royalty rate value distribution, US$million – regulatory stage
Figure 43: Cance monoclonal antibody deal royalty rate value distribution, US$million – marketed stage
Figure 44: Cancer monoclonal antibody deal royalty value – median value by stage of development
Figure 45: Top monoclonal antibody cancer deals by value since 2007
Figure 46: Online partnering resources
Figure 47: Forthcoming partnering events
Figure 48: Deal type definitions
Figure 49: Collaborative R&D agreement for BiTE antibodies against three undisclosed solid tumor targets

Published By: Current Partnering
Product Code: Current Partnering17


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