Table of Contents
Introduction
Worldwide Market and Technology Overview
A. Major Therapeutic Drug Monitoring Tests
1. Overview
2. Carbamazepine
3. Digoxin
4. Gentamicin
5. Lidocaine
6. Lithium
7. Phenytoin/Dilantin
8. Procainamide
9. Quinidine
10. Theophylline
11. Valproic Acid
B. Instrumentation Review
Abaxis Piccolo
Abaxis Piccolo Xpress
Abbott AxSYM
Abbott Architect c4000
Abbott Architect i2000 Series
Abbott Architect ci8200 System
Abbott i-STAT
Alfa Wassermann ACE Alera
AMS Liasys
Awareness Technologies ChemWell
Awareness Technology STAT FAX 4500
Beckman Coulter Unicel Series
Beckman Coulter Access
Binding Site ESP600
bioMerieux Mini Vidas
Carolina Chemistries BioLis 24i
DiaSorin Liaison
Grifols Triturus
Horiba ABX Pentra 400
Inverness DS2
J&J DT System
J&J Vitros Eci/ECiO
J&J Vitros 3600
J&J Vitros 5600
Medica EasyRA
Nova Biomedical Critical Care Xpress
Olympus AU480
Olympus AU5400
Olympus AU53000i
Olympus AU2700
Polymedco Poly-Chem
Polymedco Spotchem EZ
Randox RX Daytona
Randox RX Imola
Roche Modular Analytics
Roche Cobas Integra 400
Roche Cobas Integra 400 Plus
Roche Elecsys
Roche Cobas c311
Roche Cardiac 200
Siemens ADVIA Centaur
Siemens Dimension
Siemens Dimension RxL Max
Siemens Dimension Vista 500
Siemens Immulite
Siemens Stratus
Tosoh AIA-Series
Vital Diagnostics ATAC 8000
Vital Diagnostics Envoy 500
C. Major In Vitro Diagnostic Technologies And Their Potential Applications
1. Monoclonal and Polyclonal Antibodies
2. Immunoassays
a. Technological Principle
b. Radioimmunoassays (RIA)
c. Enzyme Immunoassays (EIA)
Overview
ELISA
EMIT
Immunofiltration
Dot Immunobinding Assays
Capillary Immunoassays
Particle-Membrane Capture Immunoassays
Enzyme Amplification
CEDIA
Electrochemical Immunoassays
d. Fluorescent Immunoassays
Fluorescence Polarization
Time-Resolved Pulse Fluorescence
e. Luminescence
Chemiluminescence
Bioluminescence
f. Latex Agglutination
g. Immunoprecipitation
h. Affinity Chromatography Immunoassays
i. Liposome Flow-Injection Immunoassays
3. IT and Automation
4. Dry Chemistry
5. Biosensors
6. Robotics
7. Chemometrics
8. Molecular Diagnostics
a. Sample Preparation
b. Hybridization
c. Separation
d. Detection/Measurement
Test Formats
a. Filter Hybridization
b. Southern Blot
c. Northern Blot
d. In Situ Hybridization
e. Others
Labeling Techniques
Amplification Methods
Polymerase Chain Reaction
Temperature Cyclers
PCR Variations
Immuno-PCR
QC-PCR.
DAP-PCR
Strand Displacement Activation
TMA
Ligase Chain Reaction
Branched DNA
Hybridization Protection Assay
Nucleic-Acid Sequence-Based Amplification
Self-Sustained Sequence Replicase
Others
Ampliprobe
CAR
CAS
CPT
Dendritic Polymer Technology
ISO-CR
LAT
Probe Networks
RAMP
Repair Chain Reaction
Rolling Circles
Sequence Independent Gene Amplification
Sequence Initiation Reaction
SISPA
Solid Phase Amplification
Detection Technologies
a. Radioactive Methods
Overview
Major Isotopes
P-32
S-35
H-3
I-125
b. Non-Isotopic Methods
Enzymatic Labels
Chemical Labeling
Indirect Chemical Labeling
Direct Chemical Labeling
Fluorescence
Chemiluminescence
Electrical Conductivity
Instrumentation Review
a. Abbott LCx
b. Beckman Coulter/Biomek FK
c. Becton Dickinson SDA
d. Bio-Rad GeneScope
e. Gen-Probe Tigris
f. Roche Cobas Amplicor
g. Tecan LS Series
Biochips: Genosensors, Microarrays, and Labs-on-the-chip
Liquid Transportation and Mixing
Separation
Reaction
Detection
France: Test Volume and Sales Forecasts
Germany: Test Volume and Sales Forecasts
Italy: Test Volume and Sales Forecasts
Japan: Test Volume and Sales Forecasts
Spain: Test Volume and Sales Forecasts
U.K.: Test Volume and Sales Forecasts
U.S.A.: Test Volume and Sales Forecasts
Alternative Market Penetration Strategies
A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies for Decentralized
Testing Markets
1. Marketing Approaches
2. Product Complexity
3. Customer Preference
4. Established Suppliers
5. Emerging Suppliers
6. Major Types of Distributors
7. Market Segmentation
Potential Market Entry Barriers and Risks
A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge and Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges
Competitive Assessments
Abbott Laboratories
AdnaGen
Ambrilia
AMDL
Beckman Coulter
Biomedical Diagnostics
BioMerieux
Bio-Rad
Canag Diagnostics
Dako
DiaSorin
Eiken
Fujirebio
Instrumentation Laboratory
J&J
Kyowa Medex
Matritech
Roche
Siemens
Sysmex
Thermo Fisher
Trinity Biotech
Tosoh
Wako
Wallac
List of Tables
Major Companies Developing or Marketing
TDM Tests
France, Laboratories Performing TDM
Tests By Market Segment
France, Hospital Laboratories Performing
TDM Tests By Bed Size
France, Commercial/Private Laboratories
Performing TDM Tests By Annual Test Volume
France, TDM Test Volume Forecast By Market Segment
France, All Market Segments, TDM
Test Volume Forecast by Assay
France, Hospital Laboratories, TDM
Test Volume Forecast by Assay
France, Commercial/Private Laboratories,
TDM Test Volume Forecast by Assay
France, TDM Reagent Market Forecast By
Market Segment
France, All Market Segments, TDM
Reagent Market Forecast by Assay
France, Hospital Laboratories, TDM
Reagent Market Forecast by Assay
France, Commercial/Private Laboratories,
TDM Reagent Market Forecast by Assay
Germany, Laboratories Performing Chemistry
TDM Tests By Market Segment
Germany, Hospital Laboratories Performing
TDM Tests By Bed Size
Germany, Commercial/Private Laboratories
Performing TDM Tests By Annual Test Volume
Germany, TDM Test Volume Forecast By Market
Segment
Germany, All Market Segments, TDM
Test Volume Forecast by Assay
Germany, Hospital Laboratories, TDM
Test Volume Forecast by Assay
Germany, Commercial/Private Laboratories,
TDM Test Volume Forecast by Assay
Germany, Physician Offices/Group
Practices, TDM Test Volume Forecast by Assay
Germany, TDM Reagent Market Forecast By
Market Segment
Germany, All Market Segments, TDM
Reagent Market Forecast by Assay
Germany, Hospital Laboratories, TDM
Reagent Market Forecast by Assay
Germany, Commercial/Private Laboratories,
TDM Reagent Market Forecast by Assay
Germany, Physician Offices/Group
Practices, TDM Reagent Market Forecast by Assay
Italy, Laboratories Performing TDM
Tests By Market Segment
Italy, Hospital Laboratories Performing
TDM Tests By Bed Size
Italy, Commercial/Private Laboratories
TDM Tests By Annual Test Volume
Italy, TDM Test Volume Forecast By Market
Segment
Italy, All Market Segments, TDM
Test Volume Forecast by Assay
Italy, Hospital Laboratories, TDM
Test Volume Forecast by Assay
Italy, Commercial/Private Laboratories,
TDM Test Volume Forecast by Assay
Italy, TDM Reagent Market Forecast By Market Segment
Italy, All Market Segments, TDM
Reagent Market Forecast by Assay
Italy, Hospital Laboratories, TDM
Reagent Market Forecast by Assay
Italy, Commercial/Private Laboratories,
TDM Reagent Market Forecast by Assay
Japan, Laboratories Performing TDM
Testing By Market Segment
Japan, Hospital Laboratories Performing
TDM Tests By Bed Size
Japan, Commercial/Private Laboratories
TDM Tests By Annual Test Volume
Japan, TDM Test Volume Forecast By Market
Segment
Japan, All Market Segments, TDM
Test Volume Forecast by Assay
Japan, Hospital Laboratories, TDM
Test Volume Forecast by Assay
Japan, Commercial/Private Laboratories,
TDM Test Volume Forecast by Assay
Japan, TDM Reagent Market Forecast By Market
Segment
Japan, All Market Segments, TDM
Reagent Market Forecast by Assay
Japan, Hospital Laboratories, TDM
Reagent Market Forecast by Assay
Japan, Commercial/Private Laboratories,
TDM Reagent Market Forecast by Assay
Spain, Laboratories Performing TDM
Testing By Market Segment
Spain, Hospital Laboratories Performing
TDM Tests By Bed Size
Spain, Commercial/Private Laboratories
TDM Tests By Annual Test Volume
Spain, TDM Test Volume Forecast By Market Segment
Spain, All Market Segments, TDM
Test Volume Forecast by Assay
Spain, Hospital Laboratories, TDM
Test Volume Forecast by Assay
Spain, Commercial/Private Laboratories,
TDM Test Volume Forecast by Assay
Spain, Ambulatory Care Centers,
TDM Test Volume Forecast by Assay
Spain, All Market Segments, TDM
Reagent Market Forecast by Assay
Spain, Hospital Laboratories, TDM
Reagent Market Forecast by Assay
Spain, Commercial/Private Laboratories,
TDM Reagent Market Forecast by Assay
Spain, Ambulatory Care Centers,
TDM Reagent Market Forecast by Assay
U.K., Laboratories Performing TDM
Testing By Market Segment
U.K., Hospital Laboratories Performing
TDM Tests By Bed Size
U.K., Commercial/Private Laboratories
TDM Tests By Annual Test Volume
U.K., TDM Test Volume Forecast By Market Segment
U.K., All Market Segments, TDM
Test Volume Forecast by Assay
U.K., Hospital Laboratories, TDM
Test Volume Forecast by Assay
U.K., Commercial/Private Laboratories,
TDM Test Volume Forecast by Assay
U.K., TDM Reagent Market Forecast By Market Segment
U.K., All Market Segments, TDM
Reagent Market Forecast by Assay
U.K., Hospital Laboratories, TDM
Reagent Market Forecast by Assay
U.K., Commercial/Private Laboratories,
TDM Reagent Market Forecast by Assay
U.S.A., Laboratories Performing TDM
Testing By Market Segment
U.S.A., Hospital Laboratories Performing
TDM Tests By Bed Size
U.S.A., Commercial/Private Laboratories
TDM Tests By Annual Test Volume
U.S.A., TDM Test Volume Forecast By Market Segment
U.S.A., All Market Segments, TDM
Test Volume Forecast by Assay
U.S.A., Hospital Laboratories, TDM
Test Volume Forecast by Assay
U.S.A., Commercial/Private Laboratories,
TDM Test Volume Forecast by Assay
U.S.A., Physician Offices/Group Practices,
TDM Test Volume Forecast by Assay
U.S.A., TDM Reagent Market Forecast By Market Segment
U.S.A., All Market Segments, TDM
Reagent Market Forecast by Assay
U.S.A., Hospital Laboratories, TDM
Reagent Market Forecast by Assay
U.S.A., Commercial/Private Laboratories,
TDM Reagent Market Forecast by Assay
U.S.A., Physician Office/Group Practices,
TDM Reagent Market Forecast by Assay