Table of Contents
Introduction
Worldwide Market and Technology Overview
A. Cancer Statistics and Etiology
1. Brest Cancer
2. Lung Cancer
3. Colon and Rectum Cancer
4. Prostate Cancer
5. Stomach Cancer
6. Leukemia
7. Lymphoma
8. Oral Cancer
9. Skin Cancer
10. Uterine Cancer
11. Ovarian Cancer
12. Bladder Cancer
B. Major Current And Emerging Cancer Diagnostic Tests
1. Introduction
2. Tumor Marker Classification
3. ACTH
4. Alpha-Fetoprotein (AFP)
5. Beta-2 Microglobulin
6. CA 15-3/27.29
7. CA 19-9
8. CA-125
9. Calcitonin
10. Carcinoembrionic Antigen (CEA)
11. Estrogen and Progesterone Receptors
12. Ferritin
13. Gastrin
14. Human Chorionic Gonadotropin (HCG)
15. Insulin
16. NSE
17. Occult Blood
18. PAP Smear/HPV
19. Prostatic Acid Phosphatase (PAP)
20. Prostate-Specific Antigen (PSA)
21. Squamous Cell Carcinoma Antigen (SCC)
22. T and B Lymphocytes
23. TdT
24. Thyroglobulin
25. Tissue Polypeptide Antigen (TPA)
26. Biochemical Tumor Markers
ADA
B-Protein
PNP
5'-Nucleotidase
27. Oncogenes
Abl/abl-bcr
AIB1
BCL-2
BRCA1
CD44
C-fos
C-myb
C-myc
CYP-17
Erb-B
HPC1
N-myc
P40
P51
P53
PIK3CA
PTI-1
Ras
Reg
Sis
Src
28. Polypeptide Growth Factors
? Basic Fibroblast Growth Factor
Beta-TGF
Cachectin (TNT)
Calmodulin
ECFR
Nerve Growth Factor (NGF)
Epidermal Growth Factor (EGF)
Ornithine Decarboxylase
Transferrin
Transforming Growth Factor-Alpha
29. Ectopic Hormones
30. Colony Stimulating Factors
31. Lymphokines
Alpha-Interferon
B Cell Growth Factors
B Cell Growth Factor (BCGF)
Gamma-Interferon
Interleukin-1 (IL-1)
Macrophage Activating Factor
32. Immunohistochemical Stains
33. Emerging Tumor Markers
N-Acetylglucosamine
Actin
Alpha-Actin
Antineuronal Antibodies
7B2
B72.3
Bax
BCD-F9
BLCA-4
Blood Group Antigens A,B,H
CA 50
CA 72-4/TAG-72
CA 195
CA-242
CA-549
CAM 26
CAR-3
Cathepsin-D
Chromogranin A and B
Cluster 1 Antigen
Cluster-5/5A Antigen
CTA
CU18
DR-70
DU-PAN-2
Endometrial Bleeding Associated Factor
Endostatin
Epithelial Membrane Antigen
Feulgen Hydrolysis
Fibronectin
FSH
(1->3)-L-fucosyltransferase
Gastrin-Releasing Peptide (GRP)
GDCFP-15
Glucagon
Glycoamines
H23
Her-2
Human Carcinoma Antigen
HPA
HSP27
Intermediate Filaments
Cytokeratins/CK18/Cyfra 21-1
Desmin
Gliofibrillary Acid Protein
Neurofilaments
Vimentin
KA 93
Kinases
KP16D3
LAI
Leukocyte Common Antigen
Lewis Antigens
Lysophosphatidic Acid (LPA)
Ma 695/Ma 552
MABDF3
MAG
ME1
Minactivin
MN/CA9
MSA
Mucin Cancer Antigen (MCA)
Multiple Tumor Suppressor 1
Myosin
NEA-130
NMP22
OA-519
Opiod Peptides
P-glycoprotein
Pancreatic Oncofetal Antigen (POA)
Placental Lactogen
PR92
Proliferative Index, Ki-67
Px
RB Inactivation/Deletion
Ret
SCCL 175
Selectin
Sialic Acid
Sialyl SSEA-1/SLX
SN10
Somatostatin
TA-90
TABA
Tachykinin
TAG 12
TPS
Troponin
Tubulin
VCAM
VEGF
Villen
C. Instrumentation Review And
Market Needs
1. Abbott AxSYM
2. Abbott Architect c4000
3. Abbott Architect i2000 Series
4. Abbott Architect ci8200 System
5. Beckman Coulter UniCel Series
6. Beckman Coulter Access
7. Binding Site ESP600
8. bioMerieux Mini Vidas
9. Carolina Chemistries BioLis 24i
10. DiaSorin Liaison
11. Horiba ABX Pentra 400
12. Inverness DS2
13. J&J Vitros ECi/ECiQ
14. J&J Vitros 3600
15. J&J Vitros 5600
16. Olympus AU5400
17. Olympus AU3000i
18. Olympus AU2700
19. Roche Modular Analytics
20. Roche Cobas Integra 400
21. Roche Cobas Integra 400 Plus
22. Roche Elecsys
23. Roche Cobas c311
24. Siemens ADVIA Centaur
25. Siemens Dimension
26. Siemens Dimension RxL Max
27. Siemens Dimension Vista 500
28. Siemens Immulite
29. Siemens Stratus
30. Tosoh AIA-Series
31. Vital Diagnostics ATAC 8000
32. Vital Diagnostics Envoy 500
D. Current and Emerging Technologies
1. Monoclonal and Polyclonal Antibodies
2. Immunoassays
a. Technological Principle
b. Radioimmunoassay (RIA)
c. Enzyme Immunoassays (EIA)
Overview
ELISA
Immunofiltration
Particle-Membrane Capture Immunoassay
Enzyme Amplification
d. Fluorescent Immunoassays
e. Luminescence
Chemiluminescence
Bioluminescence
f. Latex Agglutination
g. Immunoprecipitation
H. Affinity Chromatographu
e. Liposome Flow-Injection Immunoassay
3. Molecular Diagnostics
a. Technology Overview
b. Amplification Methods
PCR
DAP-PCR
Immuno-PCR
QC-PCR
CAR
DNA
HPA
LCR
NASBA
QBR
SDA
3 SR, and others
4. Chromosome Analysis
a. Chronic Myelogenous Leukemia (CML)
b. Acute Myeloid Leukemia (AML)
c. Acute Lymphoblastic Leukemia (ALL)
d. Malignant Lymphomas
Lymphoid Malignancies
e. Chronic Lymphocytic Leukemia (CLL)
f. Solid Cancers
g. Chromosomal Translocation and Oncogenes
5. Artificial Intelligence
6. Flow Cytometry
7. Two Dimensional Gel Electrophoresis (2-DGE)
8. Biosensors
9. Competing/Complementing Technologies
a. CT
b. MRI
c. NMR
d. PET
e. Photonics Spectroscopy
E. Personal Testing
Germany
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth and Major Suppliers
Major Product Development Opportunities
A. Reagent Kits and Test Systems/Panels
B. Instrumentation
C. Computers, Software and Automation
D. Auxiliary Products
Design Criteria for Decentralized Testing Products
Alternative Market Penetration Strategies
A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies
1. Marketing Approaches
2. Product Complexity
3. Customer Preference
4. Established Suppliers
5. Emerging Suppliers
6. Major Types of Distributors
7. Market Segmentation Factor
Potential Market Entry Barriers and Risks
A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge and Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges
Competitive Profiles
Abbott
AdnaGen
Applied Gene Technologies
Arca
Beckman Coulter/Danaher
Becton Dickinson
Biomedical Diagnostics
bioMerieux
Bio-Rad
Cepheid
Correlogic Systems
Dako
Decode
Diadexus
Diagnocure
Diasorin
Eiken Chemical
Enterix
Enzo Biochem
Epigenomics
Exact Sciences
Fujirebio
Gen-Probe
Guided Therapeutics
Hologic
Ipsogen
Kreatech
Kyowa Medex
Life Technologies
Mackay Life Sciences
Myriad Genetics
Nanogen Elitech
OncoLab
Otho-Clinical Diagnostics
Panacea Pharmaceuticals
Polartechnics
Polymedco
PreMD
Qiagen
Radient Pharmaceuticals
Roche
Scienion
Sequenom
Siemens Healthcare
Takara Bio
Targeted Diagnostics & Therapeutics
Tosoh
Veridex
Wako Pure Chemicals
Wallac/PE
Zila
Appendixes
Appendix I: Major Universities and Research
Centers Developing Cancer Diagnostic
Technology and Applications
Appendix II: Assumed Currency Exchange Rates
List of Tables
Tumor Marker Classification
Major Companies Developing or Marketing
ACTH Tests
Major Companies Developing or Marketing
AFP Tests
Major Companies Developing or Marketing
Beta-2 Microglobulin Tests
Major Companies Developing or Marketing
CA 15-3/27.29 Tests
Major Companies Developing or Marketing
CA 19-9 Tests
Major Companies Developing or Marketing
CA 125 Tests
Major Companies Developing or Marketing
Calcitonin Tests
Major Companies Developing or Marketing
CEA Tests
Major Companies Developing or Marketing
Estrogen Receptor Tests
Major Companies Developing or Marketing
Progesterone Receptor Tests
Major Companies Developing or Marketing
Ferritin Tests
Major Companies Developing or Marketing
Gastrin Tests
Major Companies Developing or Marketing
HCG Tests
Major Companies Developing or Marketing
Insulin Tests
Major Companies Developing or Marketing
NSE Tests
Major Companies Developing or Marketing
Occult Blood Tests
Major Companies Developing or Marketing
PAP Smear/HPV Tests
Major Companies Developing or Marketing
PAP Tests
Major Companies Developing or Marketing
PSA Tests
Major Companies Developing or Marketing
Lymphocyte Subclassification Tests
Biochemical Markers Potential Applications
In Cancer Diagnosis
Oncogenes Potential Applications
In Cancer Diagnosis
Major Companies Developing or Marketing
Oncogene Tests
Growth Factors Potential Applications
In Cancer Diagnosis
Colony Stimulating Factors Potential
Applications in Cancer Diagnosis
Lymphokines Potential Applications
In Cancer Diagnosis
Immunohistochemical Stains Potential
Applications in Cancer Diagnosis
Executive Summary Table: Germany, Total
Tumor Marker Test Volume and Sales Forecast
By Market Segment
Germany, Estimated Cancer Death Rates
Per 100,000 Population
Germany, Laboratories Performing Tumor
Marker Tests by Market Segment
Germany, Hospital Laboratories Performing
Tumor Marker Tests by Bed Size
Germany, Commercial/Private Laboratories
Performing Tumor Markers by Annual
Test Volume
Germany, Total Tumor Marker Test Volume
Forecast by Market Segment
Germany, All Market Segments, Major Tumor
Marker Test Volume Forecast
Germany, Hospital Laboratories, Major
Tumor Marker Test Volume Forecast by
Test
Germany, Commercial/Private Laboratories
Major Tumor Marker Test Volume
Forecast
Germany, Physician Offices/Group
Practices Major Tumor Marker
Test Volume Forecast
Germany, Total Tumor Marker Sales
Forecast by Market Segment
Germany, All Market Segments Major Tumor
Marker Sales Forecast by Test
Germany, Hospital Laboratories, Major Tumor
Marker Sales Forecast by Test
Germany, Commercial/Private Laboratories
Major Tumor Marker Sales Forecast by Test
Germany, Physician Offices/Group Practices
Major Tumor Marker Sales Forecast by Test
Germany, ACTH Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, AFP Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, Beta-2 Microglobulin Test Volume
And Diagnostics Sales Forecast by Market
Segment
Germany, CA-15-3/27.29 Test Volume and
Diagnostics Sales Forecast by Market Segment
Germany, CA-19 Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, CA 125 Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, Calcitonin Test Volume
And Diagnostic Sales Forecast by Market
Segment
Germany, Cathepsin Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, CEA Test Volume and Diagnostics Sales
Forecast by Market Segment
Germany, Chromogranin Test Volume
And Diagnostics Sales Forecast by Market Segment
Germany, Colon-Specific Antigen Test Volume
And Diagnostics Sales Forecast by Market
Segment
Germany, Cytokeratins Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, Estrogen Receptor Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, Ferritin Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, Gastrin Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, HCG, Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, Insulin Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, Interferons Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, Interleukins Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, Lymphocyte Subtyping Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, NSE Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, Occult Blood Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, Oncogenes Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, Pancreatic Oncofetal Antigen
Test Volume and Diagnostics Sales
Forecast by Market Segment
Germany, Pap Smear Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, Parathyroid Hormone Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, Progesterone Receptor Test Volume
And Diagnostics Sales Forecast by Market
Segment
Germany, PAP Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, PSA Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, S-100 Protein Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, Serotonin Test Volume and
Diagnostics Sales Forecast by Mar
Segment
Germany, Sialic Acid Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, Squamous Cell Carcinoma Antigen
Test Volume and Diagnostics Sales Forecast
By Market Segment
Germany, TDT Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, Thymidine Kinase Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, Thyroglobulin Test Volume and
Diagnostics Sales Forecast by Market
Segment
Germany, TPA Test Volume and Diagnostics
Sales Forecast by Market Segment
Germany, Total Tumor Marker Sales
By Major Supplier
Germany, AFP Testing Market Diagnostics
Sales by Major Supplier
Germany CA 15-3/27.29 Testing Market
Diagnostics Sales by Major Supplier
Germany CA 19-9 Testing Market Diagnostics
Sales by Major Supplier
Germany, CA 125 Testing Market Diagnostics
Sales by Major Supplier
Germany, CEA Testing Market Diagnostics
Sales by Major Supplier
Germany, PSA Testing Market Diagnostics
Sales by Major Supplier