Drug Delivery Systems to 2015

Published: January 2012
No. of Pages: 337
  

Report Summary

This study analyzes the market for drug delivery systems in the US. It presents historical demand data for the years 2000, 2005 and 2010, and forecasts for 2015 and 2020 by material (e.g., monoclonal antibodies, synthetic and natural polymers, nanosized particles); type (e.g., oral, parenteral, inhalation, transdermal, implantable); and application. The study also considers market environment factors, details industry structure, evaluates company market share and profiles leading industry players.

US demand to rise 7.2% annually through 2015
US demand for drug delivery products is forecast to expand 7.2 percent annually to $133 billion in 2015. The best growth opportunities will emerge in specialized pharmaceutical formulations and administration devices that advance the nature of therapy for autoimmune conditions, cancer, heart disease, neurological disorders and other debilitating health problems. Included in this group are human monoclonal antibodies, polymer encapsulated nanomedicines and transdermal patches for breakthrough pain management. Infusion products and parenteral delivery devices with improved safety, infection prevention and ease-of-use features will also fare well in the marketplace. Among these devices are retractable syringes, needleless injectors, premixed IV systems and smart infusion pumps. Based on the complex nature of therapy and the high frequency of dosing requirements, central nervous system, respiratory and hormonal indications will command the largest and fastest growth by drug delivery products.

Chewable and orally disintegrating tablets to see good growth
Demand for oral drug delivery products will increase 4.3 percent annually to over $52 billion in 2015. Controlled-release formulations will command the largest share of sales, but will lose some growth momentum due to patent expirations on several large-selling sustained-release therapies. Chewable and orally disintegrating tablets, nanoparticulate medicines and transmucosal therapies will realize faster growth in demand spurred by new product introductions and the high valueadded nature of indications served.

Monoclonal antibodies to pace parenteral products
Demand for parenteral drug delivery products will reach $54.7 billion in 2015, up eleven percent annually from 2015. Monoclonal antibodies will lead gains as advances in biotechnologies contribute new and improved therapies for autoimmune disorders, cancer and various rate debilitating diseases. Polymer-encapsulated medicines will also see fast rising demand based on contributions to the improved bioavailality and reduced toxicity of advanced parenteral compounds. Safety-engineered prefillable syringes and IV catheters, along with bag/ vial infusion systems, will command the best growth opportunities among parenteral infusion products and delivery devices due largely to infection prevention advantages.

Patches to lead gains among other drug delivery systems
Other drug delivery products will post demand of $26.1 billion in 2015, up 6.6 percent annually from 2010. Prefilled dry powder and metered dose inhalers will retain the largest share of sales, spurred largely upward trends in prevalence of asthma and chronic obstructive pulmonary disease (COPD). Less favorably, growth opportunities for these devices will decelerate as patent expirations open up several widely prescribed inhalation therapies, including sales leader ADVAIR, to generic competition. Led by new next-generation drug-eluting stents with thinner struts and enhanced safety profiles, implantable drug delivery systems will generate rebounding demand in angioplasty procedures, reversing a recent sharp sales drop. Transdermal patches will realize the fastest growth among other drug delivery systems as new therapies for breakthrough pain and various central nervous system disorders replace less effective oral medicines.

Company Profiles

Profiles for US Competitors such as Abbott Labs, Amgen, AstraZeneca, Bristol-Myers Squibb, Genentech, GlaxoSmithKline, Johnson & Johnson, Merck, Medtronic, Pfizer and others.

Additional Information:
This comprehensive study examines the US market for drug delivery products. The discussion covers specialized dosage formats and devices that improve the safety, effectiveness and/or administration ease of pharmaceutical, biological and other therapeutic agents. For the purposes of analysis, this study divides drug delivery products into three major groups:

  • oral (controlled-release, chewable, orally disintegrating, polymerbased and transmucosal)
  • parenteral (monoclonal antibodies, injectors and related devices, nanoparticulate formulations, and premixed IV solutions)
  • other (inhalation, implantable and transdermal)

Unless otherwise indicated, all statistics and forecasts represent demand for drug delivery products stated in current US dollars. The term “demand” is equivalent to “value of consumption” or “manufacturers’ sales” and correlates to the value of domestic production plus imports minus exports. Historical data (2000, 2005, 2010) and forecasts for 2015 and 2020 are provided for drug delivery products by type and application. It should be noted that the value of demand presented for controlled-release and other specialized dosage formats as well as for implantable products, prefilled inhalers, premixed IV containers and transdermal patches is based on manufacturers’ sales of finished products and includes the cost of enclosed medication. By contrast, the value of demand presented for prefillable and hypodermic syringes, IV catheters, and related parenteral delivery devices reflects sales of devices without medication.

Corporate information and data appearing in Section IX, “Industry Structure,” are based on estimates derived from published company reports and personal interviews with competitors, industry experts and sources within the companies themselves. Macroeconomic indicators were taken from The Freedonia Group Incorporated Consensus Forecasts dated August 2011. The sum of individual components appearing in the study tables may not always add to the apparent total due to independent rounding. All ratios were calculated on the basis of unrounded numbers.

Information and data related to the US market for drug delivery products were obtained from a variety of primary and secondary sources including government and trade associations, industry participants, online databases and other Freedonia studies. Primary information was gathered through consultations with officers and marketing/technical personnel of participating companies and other industry specialists. Secondary and background information were obtained from several medical and pharmaceutical publications including American Journal of Health-System Pharmacy, Drug Development & Delivery, Drug Discovery & Development, Drug Topics, Pharmaceutical Technology and R&D Directions. Corporate annual reports, SEC Form 10-K and 20-F filings, product literature, and other company information were also used extensively in framing the industry environment and as input for market size assessments.

Drug Delivery Systems to 2015

Table of Contents

INTRODUCTION

I. EXECUTIVE SUMMARY

II. MARKET ENVIRONMENT
General
Economic Factors
Demographic Patterns
HealthCare Trends
Health Insurance
Medical Conditions
Acute Conditions
Chronic Conditions
National Health Expenditures
Medical Providers
Hospitals 23
Skilled Nursing Homes
Outpatient Facilities
Physicians
Patient Activity
Hospital Activity
Surgical Procedures
Outpatient Consultations
Pharmaceutical Market Overview
Regulation 29
Research & Development
Demand Patterns
Therapeutic Classes
Dosage Formulations
Distribution Classification
Commercial Status

III.DRUGDELIVERYEXCIPIENTS
General 42
Polymers 43
Polyethylene Glycol
Acrylic Polymers
Carbomers 46
Methacrylate Copolymers
Polyethylene Oxide
Polyvinyl Alcohol
Other Synthetic Polymers
Cellulose Excipients
Ethyl Cellulose
Hydroxypropyl Methylcellulose (HPMC)
Other Cellulose Excipients
Minerals 54
Mineral Hydrocarbons
Petrolatum
Mineral Oil
Waxes 57
Other Minerals
Attapulgite
Calcium Carbonate
Calcium Silicate
Electrolytes
Other Excipients
Sterile & Purified Waters
Starch Compounds
Cyclodextrins
Dextrates 62
Dextrin 63
Maltodextrin
Sugars & Polyols
Sucrose 63
Sorbitol 64
Lactose 65
Mannitol 65
Natural Gums 66
All Other Excipients

IV. DRUG DELIVERY PRODUCTS OVERVIEW
General 68
Types of Drug Delivery Products
Historical Market Trends
Regulation 75
Research & Development
US Trade 77
International Markets

V. ORAL DRUG DELIVERY PRODUCTS
General 81
Controlled - Release Formulations
Coated Products
Diffusion Products
Reservoir Products
Chewable Tablets
Nanoparticulate Formulations
Orally Disintegrating Tablets (ODT)
Transmucosal Formulations

VI.PARENTERAL DRUG DELIVERY PRODUCTS
General
Therapeutic Monoclonal Antibodies
Types of Monoclonal Antibodies
Marketed Products
Therapeutic Monoclonal Antibodies in Development
Encapsulated Parenteral Drug Delivery Products
Polymer - Protected Products
PEG - Based Parenteral Therapies
Other Polymer - Protected Parenteral Therapies
Developmental Activities
Liposomes
Marketed Products
Developmental Activities
Infusion Products
IV AdministrationSets
Premixed IV Solutions
Infusion Pumps
Other Infusion Products
Enteral Feeding Supplies
IV Accessories
Parenteral Drug Delivery Devices
Prefillable Syringes
Injectors
Cartridges
Hypodermic Syringes
IV Catheters
Other Parenteral Delivery Devices

VII. OTHER DRUG DELIVERY PRODUCTS
General
Inhalation Drug Delivery Products
Dry Powder Formulations
Types of DPIs
Developmental Activities
Metered Dose Formulations
3M Drug Delivery Systems
Other Producers
Implantable Drug Delivery Products
Drug - Eluting Stents
Other Implantable Drug Delivery Products
Drug Inserts
Brachytherapy
Drug Pumps
Transdermal Drug Delivery Products
Transdermal Technologies
Central Nervous System Agents
Other Transdermal Therapies
Hormones & Related Agents
OXYTROL
Cardiovascular Agents
Nicotine Patches
Scopolamine

VIII. APPLICATIONS
General
Central Nervous System Agents
Respiratory Agents
Hormones & Related Agents
Gastrointestinal Agents
Cardiovascular Agents
Anti - Infective Agents
Nutritional Agents
Genito - Urinary Agents
Other Pharmaceuticals

IX. INDUSTRY STRUCTURE
General
Market Share
Competitive Strategies
Mergers & Acquisitions
Licensing & Related Agreements
Marketing & Distribution
Manufacturing
Company Profiles
Abbott Laboratories
Amgen Incorporated
Aptalis Pharma Incorporated
Aptar Group Incorporated
AstraZeneca plc
Aveva Drug Delivery Systems, see Nitto Denko
Axcan Intermediate Holdings, see Aptalis Pharma
Baxa, see Baxter International
Baxter International Incorporated
Becton, Dickinson and Company
Boehringer Ingelheim GmbH
Boston Scientific Corporation
Braun (B.) Melsungen AG
Bristol - Myers Squibb Company
Cephalon, see Teva Pharmaceutical Industries
Conor Medsystems, see Johnson & Johnson
Cordis, see Johnson & Johnson
Eurand, see Aptalis Pharma
Evonik Industries AG
Facet Biotech, see Abbott Laboratories
Genentech, see Roche Holding
Genzyme, see Sanofi - Aventis
Glaxo Smith Kline plc
Hospira Incorporated
Im Clone Systems, see Lilly (Eli)
Janssen Pharmaceuticals, see Johnson & Johnson
Johnson & Johnson
Lilly (Eli) and Company
Medingo, see Roche Holding
Merck & Company Incorporated
Nitto Denko Corporation
Novartis AG
Novo Nordisk A/S
Ortho - McNeil - Janssen Pharmaceuticals, see Johnson & Johnson
Pfizer Incorporated
Roche Holding Limited
Sanofi - Aventis
Teva Pharmaceutical Industries Limited
3M Company
Unilife Corporation
West Pharmaceutical Services Incorporated

LIST OF TABLES

SECTIONI -- EXECUTIVE SUMMARY
Summary Table 3
SECTIONII -- MARKET ENVIRONMENT
1 Macroeconomic Indicators
2 Population by Age Group
3 Health Insurance Coverage of the US Population
4 Acute Conditions by Type
5 Chronic Conditions by Type
6 National Health Expenditures by Type
7 Medical Providers by Type
8 Patient Activity by Type & Volume
9 Pharmaceutical Demand by Therapeutic Class
10 Pharmaceutical Demand by Dosage Formulation
11 Pharmaceutical Demand by Distribution Classification
12 Pharmaceutical Demand by Commercial Status
SECTION III-- DRUG DELIVERY EXCIPIENTS
1 Drug Delivery Excipient Demand by Product Group
2 Polymer Drug Delivery Excipient Demand by Type
3 Cellulose Drug Delivery Excipient Demandby Type
4 Mineral Drug Delivery Excipient Demand by Type
5 Other Drug Delivery Excipient Demand by Type
SECTION IV -- DRUG DELIVERY PRODUCTS OVERVIEW
1 Drug Delivery Product Demand by Dosage Formulation
2 Drug Delivery Product Demand, 2000 - 2010
3 US Trade in Drug Delivery Products
4 World Drug Delivery Product Demand by Region
SECTION V -- ORAL DRUG DELIVERY PRODUCTS
1 Oral Drug Delivery Product Demand by Type
2 Oral Controlled - Release Drug Delivery Product Demand by Type, Mode of Action & Application
3 Oral Coated Drug Delivery Product Demand
4 Oral Diffusion Drug Delivery Product Demand
5 Oral Reservoir Drug Delivery Product Demand
6 Chewable Tablet Demand by Therapeutic Class
7 Oral Nanoparticulate Product Demand by Application
8 Orally Disintegrating Tablet (ODT) Demand by Application
9 Transmucosal Product Demand
SECTION VI -- PARENTERAL DRUG DELIVERY PRODUCTS
1 Parenteral Drug Delivery Product Demand by Type
2 Therapeutic Monoclonal Antibody Demand by Application
3 Therapeutic Monoclonal Antibodies Approved for US Sale
4 Encapsulated Parenteral Product Demand by Type & Application
5 Infusion Product Demand by Type
6 Parenteral Delivery Device Demand by Type
SECTION VII -- OTHER DRUG DELIVERY PRODUCTS
1 Other Drug Delivery Product Demand by Type
2 Inhalation Drug Delivery Product Demand by Type
3 Dry Powder Inhaler (DPI) Product Demand
4 Metered Dose Inhaler (MDI) Product Demand
5 Implantable Drug Delivery Product Demand by Type & Application
6 Drug - Eluting Stent Demand
7 Other Implantable Drug Delivery Product Demand by Type
8 Transdermal Product Demand by Application
SECTION VIII -- APPLICATIONS
1 Drug Delivery Product Demand by Application
2 Central Nervous System (CNS) Drug Delivery Product Demand by Type
3 Respiratory Drug Delivery Product Demand by Type
4 Hormone & Related Drug Delivery Product Demand by Type
5 Gastrointestinal Drug Delivery Product Demand byType
6 Cardiovascular Drug Delivery Product Demand by Type
7 Anti - Infective Drug Delivery Product Demand by Type
8 Nutritional Drug Delivery Product Demand by Type
9 Genito - Urinary Drug Delivery Product Demand by Type
10 Drug Delivery Product Demand in Other Pharmaceuticals by Type
SECTION IX -- INDUSTRY STRUCTURE
1 US Drug Delivery Product Sales by Company, 2010
2 Selected Acquisitions & Divestitures
3 Selected Cooperative Agreements

LIST OF CHARTS

SECTION IV -- DRUG DELIVERY PRODUCTS OVERVIEW
1 Drug Delivery Product Demand by Dosage Formulation, 2010
SECTION V -- ORAL DRUG DELIVERY PRODUCTS
1 Oral Drug Delivery Product Demand by Type, 2010
2 Oral Controlled - Release Drug Delivery Product Demand by Type, 2010
SECTION VI -- PARENTERAL DRUG DELIVERY PRODUCTS
1 Parenteral Drug Delivery Product Demand by Type, 2010
SECTION VII -- OTHER DRUG DELIVERY PRODUCTS
1 Other Drug Delivery Product Demand by Type, 2010
SECTION VIII -- APPLICATIONS
1 Drug Delivery Product Demand by Application, 2010
SECTION IX -- INDUSTRY STRUCTURE
1 Drug Delivery Dosage Formulations, US Market Share, 2010
2 Drug Delivery Devices, US Market Share, 2010

Published By: Freedonia Group
Product Code: Freedonia Group60


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