Asthma Therapeutics in Asia-Pacific Markets to 2023 - High Prevalence and Highly Priced Existing & Upcoming Biologics will Drive the Market

Published: June 2017
No. of Pages: 134
    ReportsandReports

Asthma is a common chronic inflammatory disease of the airways. It is characterized by recurrent attacks of breathlessness and wheezing that vary in frequency and severity from patient to patient. Variable degrees of airflow obstruction, bronchial hyper-responsiveness and underlying inflammation determine the severity of the disease in each patient. The exact nature of the underlying inflammation reflects different aspects of the disease, such as its persistence or intermittency, and whether symptoms are chronic or acute (NHLBI, 2007). The inflammatory response and disease progression underlying asthma is mediated by various types of inflammatory cells and other cellular elements, which may include mast cells, neutrophils, eosinophils, lymphocytes and macrophages

Asthma treatment can be classed as either long-term control medication, aimed at controlling persistent asthma, or quick-relief medication, for the relief of exacerbations and acute symptoms. Long-term control medication includes inhaled corticosteroids (ICS), immunomodulators, leukotriene modifiers, cromolyn sodium, nedocromil and methylxanthines. In addition, long-acting beta-adrenoceptor agonists (LABA) can be used in combination with ICSs but not as monotherapies for moderate or severe persistent asthma. Currently, only two biologics Xolair (omalizumab) and Nucala (mepolizumab) are approved as add-on therapy for the treatment of allergic and severe refractory eosinophilic asthma in the Asia-Pacific region.

Asia-Pacific asthma therapeutics market is forecast to grow significantly over the forecast period, from $4.1 billion in 2016 to a projected value of $6 billion by 2023, at a compound annual growth rate (CAGR) of 5.4%

The aging population is growing significantly, which will increase the asthma prevalence in the Asia-Pacific region. In addition, the severity of asthma increases with age, meaning elderly patients require more medications to control their asthma symptoms, which will drive the market (Kopnina, 2012). The prevalence rate of asthma in the Asia-Pacific region in the elderly population is 1.3-15.3%, compared with 5% in the adult population (Song et al., 2014).

The late-stage pipeline contains promising targeted therapies that have the potential for approval and launch during the forecast period. There are four costly biologics that are set to enter the Asia-Pacific asthma therapeutics market: Teva’s reslizumab, Sanofi/Regeneron’s dupilumab, and AstraZeneca’s tralokinumab and benralizumab.

China has a lack of biologic development, despite having the second highest asthma prevalence population after India. In addition, the only approved biologic Xolair (omalizumab) is yet to be approved in China, and although it has been available in India since before 2009, its market uptake there is negligible. These findings clearly indicate that there is a significant drug affordability barrier in India and China.

The report “Asthma Therapeutics in Asia-Pacific Markets to 2023 High Prevalence and Highly Priced Existing & Upcoming Biologics will Drive the Market” provides an introduction to asthma, detailing the epidemiology, etiology, diagnostic techniques, pathophysiology and prognosis for patients. An analysis of current treatment algorithms and options is also included.

In depth, this report provides the following -

  • Provides detailed analysis of the drugs currently marketed for asthma: Arnuity, Seretide/Adoair, Symbicort, Relvar/Breo, Flutiform, Xolair, Montelukast sodium, Spiriva and Nucala. This includes key characteristics, covering safety and efficacy, clinical trial outcomes, tolerability, dosing, administration, prices and overall competitive strength. These products are also compared in a comprehensive heat map.
  • Provides detailed analysis of the pipeline for asthma, by stage of development, molecule type, program type, mechanism of action and molecular target.
  • Provides detailed analysis of recent clinical trials in this indication by enrollment, duration and failure rate. Finally, promising late-stage pipeline molecules are analyzed and assessed in terms of their potential competitive strength.
  • Supplies forecasts for the asthma market for the 2016-2023 period, including epidemiology, treatment usage patterns, pricing and market size. The five Asia-Pacific markets are covered, and data are presented at a country level.
  • Provides detailed analysis of key market drivers and barriers for the asthma market.

Scope

The current asthma market in the Asia-Pacific region contains novel products, including Xolair, a recombinant humanized monoclonal anti-IgE antibody; Seretide/Adoair, an ICS-LABA combination therapy; Relvar/Breo, another ICS-LABA combination therapy; and Spiriva, a LAMA.

  • What are the competitive advantages of the existing novel drugs?
  • With over 290 active pipeline molecules, most of the late-stage investigational drug candidates offer improved dosing regimens and administration routes in comparison to currently marketed products.
  • Which classes of novel drugs are most prominent within the pipeline?
  • How much potential is there for the pipeline to address unmet needs within the asthma market?
  • Analysis of clinical trials since 2006 has identified that the failure rates of asthma molecules were highest in Phase III (60%).
  • How do failure rates vary by product stage of development, molecule type, and mechanism of action?
  • How do other factors, such as average trial duration and trial size influence the costs and risks associated with product development?
  • Over the 2016-2023 forecast period the asthma therapeutics market in the Asia-Pacific region is expected to increase in value at a compound annual growth rate of 5.4%, from $4.1 billion to over $6 billion.
  • Which markets make the most significant contribution to the current market size?
  • What are the epidemiology trends in these markets?
  • Will new market entrants lead to substantial changes in annual therapy costs?
  • How will different treatment usage patterns impact growth in the five assessed Asia-Pacific markets?

Reasons to buy

  • Understand the clinical context of asthma by considering symptoms, etiology, pathophysiology, epidemiology, diagnosis, and treatment options.
  • Identify the therapeutic strategies, products, and companies that dominate the current marketed products landscape, and recognize gaps and areas of unmet need.
  • Identify key pipeline trends in molecule type, administration route, mechanism of action and novelty. Analyze the asthma pipeline and stratify pipeline therapies by stage of development, molecule type and molecular target. There are signs in the pipeline that the industry is seeking novel approaches to meet unmet needs within asthma.
  • Consider market opportunities and potential risks by examining trends in asthma clinical trial size, duration, and failure rate by stage of development, molecule type, and mechanism of action.
  • Recognize the late-stage pipeline molecules that have demonstrated strong therapeutic potential in asthma by examining clinical trial data and multi-scenario product forecast projections.
  • Compare treatment usage patterns, annual therapy costs, and market growth projections for China, India, Australia, South Korea and Japan.
  • Discover trends in licensing and co-development deals concerning asthma products and identify the major strategic consolidations that have shaped the commercial landscape.

Published By: GBI Research
Product Code: GBI Research1622


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