Next Generation Sequencing: Opportunities, Trends and World Market

Report Summary

This report is about the fast-growing worldwide market for next-generation sequencing (NGS) tools and services. NGS systems makers are effectively driving down the cost of sequencing a human genome. Once the cost of full genome sequencing drops to $1,000 or less, scientists will be able sequence human genomes at the massive scale needed to better understand human variation and help open the gateway to personalized medicine. New NGS markets in medical, agriculture, bio-fuels, forensics, or others will emerge.

This must-have report discusses its interesting topics with key findings. Within a short time, the commercial NGS systems have seen a rapid uptake as these systems have been deployed into large genome centers, non-profit institutes, cancer research centers, drug makers, diagnostics firms and service providers worldwide. The report estimates that the total NGS tools and service market will reach $1.3 billion in 2011 and grow at a high double digit growth rate over the next 5-years. The report shows that various NGS systems are available to fill nearly every customer need, from high production volumes, to small scale, or to special niches.

The study reviews the technologies that these new NGS machines use and what kinds of applications and research projects that the scientists are doing. The report discusses government research grants and private initiatives. The report studies NGS service providers that outsource to pharma and biotech companies or other customers because the technologies might help them become more productive faster. Service providers such as Complete Genomics, GATC, PerkinElmer and others are convenient resources.

Takeda Pacific offers this report in an interactive PDF format. The interactive feature uses hyperlinks that enable the reader to click the mouse to jump from Table of Contents items to sections inside the report. The hyperlinks also allow the reader to click on links to Internet information.

This report is for business executives, entrepreneurs, venture capitalists, investors, product managers, research managers, business development managers, government officials and other decision makers. The research study discusses NGS products and services from Illumina, Life Technologies, Roche 454, Helicos Biosciences, Ion Torrent, Pacific Biosciences, Oxford Nanopore Technologies, and others.

The report uses 61 figures and tables to illustrate the findings. The study features convenient tables that help the reader scan the details of key trends, market segmentation, forecasts, M&As, alliances, grant funding, patents and so forth. The study profiles the activities of 19 companies.

TABLE OF CONTENTS

1. Next-Gen. Sequencing (NGS) Market Landscape
CE and NGS for Life Science Research
Genome Sequencing Equipment Systems
Sanger-based CE Sequencing Systems
NGS Systems In Development
Bioinformatics Software
Genome Sequencing Organizations
IT Infrastructure and Applications
Others
NGS Applications & Projects for R&D
Academic Life Science Applications
Research Sequencing Applications
Pharma/ Biotech Drug Discovery/ Diagnostics R&D
Clinical Diagnostic Applications and Projects
Public Health Applications
Emerging ‘Personal Genomics’ Applications
Agricultural/ Veterinary/Bio-energy Applications
Metagenomics Applications
Other Related Applications

2. Technology Developments in NGS
The Emergence of Next-Generation DNA Sequencing Technology Initiatives
The NIH Launched its Initiative for Sequencing the Genome for $1,000 or Less
The Archon X PRIZE for Genomics: $10 Million Goes to...
Developing Near Term and Emerging NGS Technologies
Near-Term Goal: Driving to a Low-Cost Genome
$1,000 Genome Time Line

3. Commercializing NGS Technologies
Commercial NGS Technologies for the Sub-$10,000 Genome
Sample Preparation
Sequencing
Data Analysis
Roche/ 454 Life Sciences, Inc.  GS FLX and GS Junior.
Illumina, Inc. HiSeq, Genome Analyzer llx and MiSeq
Life Technologies SOLiD and Ion Torrent PGM
Danaher Motion Polonator G.007 - Open Source Polony Sequencing System
Helicos BioSciences Inc. , HeliScope, A 3G Platform That  Uses Single-Molecule Sequencing
Emerging Nanopore and 3G Technologies for  Low-Cost Genome Sequencing
Pacific BioSciences, Inc. Real Time Single-Molecule Sequencing
Oxford Nanopore Technologies, Ltd. – BASE™ Technology

4. Major Alliances, M&As & Patents
Summary of Key Alliances and M&As
Definitions of Alliance and M&A Deal Types
Highlights of Key Alliances and M&As
Data Tables for Alliances and M&As
IP, Business Development and Challenges
Summary of Key Patents Involving Sequencing Technologies
The Business Value of IP
IP Challenges

5. Next-Generation Sequencing (NGS) Tools & Service Market Size
The Total Worldwide Market Size, 2010-2015
NGS Market Size by Products & Services
Methodology and Definitions
Market Segmentation
Estimating Unit Shipments and Revenues
NGS Tools & Service Market By Major Product & Service Segments
NGS Tools & Service Market By Major Product & Service Segments & Revenues
NGS Tools & Service Market By Major Product & Service Segment Shares
NGS Equipment  & Consumables Market Segment by Subsegments & Revenues
NGS Equipment  & Consumables Market by Subsegments & Market Shares
NGS Equipment Units Shipped Each Year and Estimated NGS Installed Base
The NGS Equipment and Consumables Market by Top Vendors, Revenues & Market Shares
The IT,  Storage Tech., NGS BioInfo & Software Market Segment By Subsegments & Revenues
The Commercial NGS Service Provider Market Segment by Top Vendors & Revenues
NGS Tools & Service Market by Major NGS Application Segments
NGS Tools & Service Market by Customer Segments
NGS Tools & Service Market by WW Regions

6. Conclusions and New Business Opportunities
NGS Opportunities and Challenges
The Human Genome Project
Cumulative Advances in Technology Enabled NGS Developments
Driving to the $1,000 Genome and Beyond
The X PRIZE for Genomics Fosters Race to Reach the $10,000 Genome
Key M&As Enabled Commercial Next-Gen. Sequencing Platforms
Barriers to Market Entry Are Getting More Challenging
Enormous Amounts of NGS Data Challenge Researchers
Personal Genomics Hits Challenges
Famous Individuals and Their Genomes
Government Regulators
Clinical Sequencing for Diagnostic & Therapy Guidance
Some Hot Development Areas in NGS
NGS Systems May Replace CE Sequencing and Enable New Applications
Automated Sample Preparation
Capture Microarrays & DNA Preparation for Targeted and Exome Sequencing
Large-Scale International Sequencing Projects Use NGS
Scientists Want to Sequence 100,000’s of Humans to Enable Personal Medicine
The 1,000 Genomes Project
Human Microbiome Project
The Cancer Genome Atlas (US)
The Wellcome Trust Sanger Institute’s Cancer Genome Project
NGS Business Opportunities
Opportunities or Implications for the US
Opportunities or Implications for Europe
Opportunities or Implications for Japan and Asia

7. Profiles of Companies in Next Generation Sequencing
23andMe, Inc.
454 Life Sciences (Roche)
Affymetrix, Inc.
BioTeam, Inc.
DeCODE genetics, Inc.
DNASTAR, Inc.
GATC Biotech AG
Genomatix Software GmbH
GenomeQuest, Inc.
Helicos Biosciences Corporation
Illumina, Inc.
Intelligent Bio-Systems, Inc.
Knome, Inc.
Life Technologies, Inc.
NABsys, Inc.
Navigenics, Inc.
Oxford Nanopore Technologies Ltd.
Pacific Biosciences, Inc.
SeqWright, Inc.

8. Appendix
Glossary
Key Genome Sequencing Centers
Interesting Blogs Supporting NGS
Key Patents
About Takeda Pacific
About the Authors

LIST OF TABLES

Table 1. Sequencer Vendor Provided Software
Table 2. Selected Commercial Software
Table 3. Selected Open Source Short-Read Assembly Software
Table 4. Next-Generation Sequencing Tech. Grants Awarded FY 2004
Table 5. Next-Generation Sequencing Tech. Grants Awarded FY 2005
Table 6. Next-Generation Sequencing Tech. Grants Awarded FY 2006
Table 7. Next-Generation Sequencing Tech. Grants Awarded FY 2007
Table 8. Next-Generation Sequencing Tech. Grants Awarded FY 2008
Table 9. Next-Generation Sequencing Tech. Grants Awarded FY 2009
Table 10. Next-Generation Sequencing Tech. Grants Awarded FY 2010
Table 11.  Competing Teams for the X PRIZE for Genomics
Table 12. Summary of Key Alliances and M&As, Mar/2005 to Jun/2008
Table 13. Key Alliances Jan-Jun 2008
Table 14. Key Alliances Jan-Dec 2007
Table 15. Key Alliances Jan-Dec 2006
Table 16. Key Alliances Mar-Dec 2005
Table 17. NGS Related US Patents Issued to Orgs., 2007 to May/2008
Table 18. Key Acquisitions in Next-Generation Sequencing.
Table 19. Total NGS Tools & Service Market 2010-2015
Table 20. NGS Tools & Service Market By Major Product & Service Segment & Revenues
Table 21. NGS Tools & Service Market by Segments & Shares
Table 22. NGS Equipment  & Consumables Market by Subsegments & Revenues $M
Table 23. NGS Equipment  & Consumables Market by Subsegments & Market Share %
Table 24. NGS Equipment Units Shipped Each Year and Estimated Installed Base
Table 25. NGS Equipment & Consumables Market Segment By Top NGS Vendors & Revenues to 2015
Table 26. NGS Equipment & Consumables Segment By Top NGS Vendors and Projected Market Shares %
Table 27. IT,  Storage Tech., NGS BioInfo. & Software Market By Subsegments & Revenues
Table 28. IT,  Storage Tech., NGS BioInfo. & Software Market Subsegments & Market Shares %
Table 29. Commercial NGS Service Provider Market by Revenues
Table 30. Commercial NGS Service Provider Market by Top 15 Vendors & Revenues to 2015
Table 31. NGS Tools & Service Market By Application Segments
Table 32. NGS Tools & Services Market By Applications Market Share %
Table 33. NGS Tools & Service Market By Customer Segments by Spending $M
Table 34. NGS Tools & Service Market By Customer Type Spend  and Market Share %
Table 35. NGS Tools & Service Market By WW Regions & Revenues
Table 36. Applications Unique to Next-Generation Sequencers
Table 37. Capture Arrays & DNA Sample Preparation for Targeted/ Exome NGS
Table 38. Opportunities or Implications for the US
Table 39. Opportunities or Implications for Europe
Table 40. Opportunities or Implications for Japan and Asia
Table 41. Large International Genome Sequencing Centers
Table 42. Blogs and Communities Supporting NGS
Table 43. Recent Patents for Genome Sequencing

LIST OF ILLUSTRATIONS

Figure 1. Cost of Sequencing a Full Genome
Figure 2. The NGS Tools and Service Market Landscape
Figure 3. Roche/ 454 GS FLX DNA Sequencer
Figure 4. Illumina Genome Analyzers
Figure 5. The Life Technologies 5500xl, 5500 SOLiD and Ion Torrent Sequencing Systems
Figure 6. The Danaher Polonator G.007
Figure 7. Helicos HeliScope Sequencer
Figure 8. Simultaneous & Continuous Excitation & Detection in a ZMW
Figure 9. Pacific BioSciences Sequencing instrument
Figure 10. Exonuclease Nanopore DNA Sequencing Method
Figure 11. The Oxford Nanopore GridION Flexible Deployment Scale
Figure 12. Total NGS Tools & Service Market 2010-2015
Figure 13. NGS Tools & Service Market By Major Product & Service Segments & Revenues
Figure 14. NGS Tools & Service Market By Segment Shares
Figure 15. NGS Equipment & Consumables Market Segment By NGS Vendors & Revenues to 2015
Figure 16. NGS Tools & Service Market By Application Segments
Figure 17. NGS Tools & Service Market By Customer Segments
Figure 18. NGS Tools & Service Market By WW Regions